4NRE.A | ALOX15B

General Structure Information

PDB ID	4nre
HGNC Gene Label(s)	ALOX15B
Structure Name	the structure of human 15-lipoxygenase-2 with a substrate mimic
Resolution	2.63Å
Reference	AUTH M.J.KOBE,D.B.NEAU,C.E.MITCHELL,S.G.BARTLETT,M.E.NEWCOMERTITL THE STRUCTURE OF HUMAN 15-LIPOXYGENASE-2 WITH A SUBSTRATETITL 2 MIMIC.REF J.BIOL.CHEM. V. 289 8562 2014REFN ISSN 0021-9258PMID 24497644DOI 10.1074/JBC.M113.543777

Variant Set Distributions

ExAC Variants

Number Of Residues	675
Number Of SNVs	184
Number Of Permutations	54930
Optimal Distance Threshold	30.0
K Statistic	0.417
p-value	0.35

COSMIC

Number Of Residues	675
Number Of SNVs	7
Number Of Permutations	3801
Optimal Distance Threshold	15.0
K Statistic	0.143
p-value	0.923

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	184
Number Of COSMIC SNVs	7
Optimal Distance Threshold	49.0
K Statistic	0.148
p-value	0.71

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:7942480		E>K	A:3	(-43.62, -65.06, -20.42)
17:7942495		V>M	A:8	(-28.23, -63.79, -24.76)
17:7942502		T>N	A:10	(-22.21, -63.92, -28.42)
17:7942516	rs145035264	G>R	A:15	(-14.37, -68.30, -30.95)
17:7942519		A>T	A:16	(-16.79, -65.90, -29.28)
17:7942532		D>G	A:20	(-22.59, -75.83, -27.14)
17:7942537		V>L	A:22	(-26.92, -71.94, -23.47)
17:7942559	rs138830954	T>N	A:29	(-37.14, -63.15, -3.55)
17:7942561	rs370620348	R>W	A:30	(-42.48, -66.07, -3.89)
17:7942582	rs577729599	P>S	A:37	(-34.77, -74.35, -22.72)
17:7942589		D>V	A:39	(-33.21, -73.76, -28.28)
17:7942592		N>S	A:40	(-34.36, -69.96, -30.94)
17:7942604		E>G	A:44	(-28.64, -70.25, -31.22)
17:7942618		A>P	A:49	(-24.96, -62.85, -31.96)
17:7942704		E>K	A:50	(-28.15, -59.20, -29.87)
17:7942715		F>L	A:53	(-33.41, -66.90, -26.59)
17:7942729		P>L	A:58	(-42.54, -73.65, -14.17)
17:7942737		V>I	A:61	(-39.35, -66.69, -9.34)
17:7942740	rs377605213	G>R	A:62	(-40.58, -63.24, -7.57)
17:7942744		R>Q	A:63	(-36.40, -57.94, -6.58)
17:7942750		L>P	A:65	(-32.49, -62.46, -6.05)
17:7942765	rs561623199	H>R	A:70	(-26.83, -73.98, -16.36)
17:7942773	rs370141751	P>S	A:73	(-21.77, -80.46, -24.87)
17:7942785	rs78230493	P>A	A:77	(-28.70, -90.59, -29.68)
17:7942791		L>M	A:79	(-22.43, -91.69, -30.18)
17:7942794		G>R	A:80	(-22.86, -89.15, -25.96)
17:7942797	rs200952059	P>S	A:81	(-21.33, -85.88, -24.52)
17:7942804		A>V	A:83	(-16.72, -81.50, -27.64)
17:7942848	COSM985859	R>W	A:98	(-48.69, -55.67, -17.32)
17:7943222		K>E	A:124	(-26.26, -53.95, -5.14)
17:7943229		S>F	A:126	(-21.22, -56.27, 1.01)
17:7943249	rs577527240	V>M	A:133	(-29.81, -65.95, -2.24)
17:7943264		R>C	A:138	(-21.05, -60.21, -2.78)
17:7943267	rs544820525	Q>K	A:139	(-19.78, -65.16, 0.78)
17:7943275		E>D	A:141	(-17.76, -65.14, -6.83)
17:7943277		L>P	A:142	(-14.85, -63.20, -3.57)
17:7943280		Q>P	A:143	(-13.86, -69.60, -1.76)
17:7943285		R>W	A:145	(-12.92, -64.24, -8.61)
17:7943295		M>T	A:148	(-9.57, -69.41, -10.61)
17:7945709	rs368244992	W>G	A:158	(11.33, -59.44, -7.32)
17:7945713	rs145949381	P>R	A:159	(6.71, -57.45, -5.78)
17:7945715		H>Y	A:160	(4.47, -62.02, -3.32)
17:7945725	rs139800287	D>G	A:163	(0.86, -69.34, -8.81)
17:7945726	rs143947647	D>E	A:163	(0.86, -69.34, -8.81)
17:7945733		T>P	A:166	(3.87, -71.63, -18.64)
17:7945750		E>D	A:171	(-7.73, -69.16, -16.63)
17:7945751		L>F	A:172	(-9.89, -69.14, -22.00)
17:7945755	rs146390239	N>S	A:173	(-11.33, -65.51, -18.42)
17:7945788		F>S	A:184	(3.29, -59.89, -29.60)
17:7945809	rs568399473 COSM985863	A>V	A:191	(11.09, -57.82, -36.17)
17:7946133		R>C	A:203	(28.32, -57.54, -36.26)
17:7946178		N>D	A:218	(18.31, -49.46, -42.32)
17:7948176	COSM1182577	A>T	A:236	(19.70, -28.84, -24.28)
17:7948189		S>F	A:240	(15.39, -32.23, -22.31)
17:7948194		F>L	A:242	(17.16, -36.01, -17.22)
17:7948201		N>S	A:244	(10.06, -34.14, -22.00)
17:7948213		P>L	A:248	(10.00, -38.78, -17.02)
17:7948215		V>I	A:249	(10.29, -40.51, -12.79)
17:7948225	rs142322486	R>H	A:252	(16.23, -33.68, -5.90)
17:7948227	rs147889634	R>C	A:253	(13.17, -27.41, -6.22)
17:7948228		R>H	A:253	(13.17, -27.41, -6.22)
17:7948239	rs141534086	L>F	A:257	(25.20, -30.12, -3.98)
17:7948253	rs567291621	F>L	A:261	(28.08, -34.14, -6.61)
17:7948269	rs367867264	M>V	A:267	(33.95, -27.42, -10.52)
17:7948270		M>T	A:267	(33.95, -27.42, -10.52)
17:7948276		A>V	A:269	(31.83, -20.26, -12.74)
17:7948293	rs146184262	G>R	A:275	(26.45, -12.84, -11.67)
17:7948297		T>I	A:276	(25.08, -15.55, -9.55)
17:7948559		G>S	A:285	(16.01, -23.01, -6.75)
17:7948560	rs138883222	G>D	A:285	(16.01, -23.01, -6.75)
17:7948580		H>Y	A:292	(21.06, -42.31, -11.74)
17:7948583		G>S	A:293	(22.58, -43.91, -6.54)
17:7948586		I>V	A:294	(19.03, -47.41, -6.54)
17:7948596		G>V	A:297	(27.59, -51.46, -6.62)
17:7948598		I>V	A:298	(24.00, -53.00, -9.15)
17:7948613		I>L	A:303	(27.33, -58.80, -22.82)
17:7948629		Q>R	A:308	(29.57, -55.94, -19.56)
17:7948632	rs140323445	F>S	A:309	(32.11, -52.64, -16.46)
17:7948635	COSM1387567	S>C	A:310	(27.09, -50.12, -14.10)
17:7948638	rs148602477	A>V	A:311	(27.72, -46.13, -13.40)
17:7948640	rs138027535	A>S	A:312	(26.00, -44.86, -9.79)
17:7948676	rs374698048	G>R	A:324	(15.22, -21.15, -20.80)
17:7948680	rs367758401	P>L	A:325	(18.01, -23.59, -22.02)
17:7948691	rs560040920	L>V	A:329	(25.91, -26.97, -14.01)
17:7948701		Q>L	A:332	(30.40, -37.70, -9.30)
17:7948816	rs571724269	G>S	A:338	(37.61, -38.43, -5.64)
17:7948829	rs145968454	P>L	A:342	(36.96, -37.60, -12.52)
17:7948834		F>L	A:344	(33.73, -35.89, -15.96)
17:7948847	rs370629917	D>V	A:348	(35.59, -30.95, -19.99)
17:7948853	rs375349923	K>R	A:350	(33.98, -34.06, -29.09)
17:7948859		D>G	A:352	(35.99, -36.21, -21.43)
17:7948885	rs370434436 COSM985876	R>C	A:361	(20.71, -41.17, -21.44)
17:7948886	rs138546498	R>H	A:361	(20.71, -41.17, -21.44)
17:7948894	COSM357844	E>K	A:364	(18.58, -43.01, -17.35)
17:7948901	COSM230757	S>F	A:366	(19.81, -49.76, -15.91)
17:7948907	rs183398745	H>R	A:368	(13.04, -47.00, -17.80)
17:7948911	rs368688641	E>D	A:369	(13.98, -50.93, -18.53)
17:7948919	rs372320255 COSM1387569	T>M	A:372	(10.39, -46.49, -14.13)
17:7948932	rs573725507	H>Q	A:376	(7.66, -48.55, -10.11)
17:7948937		H>R	A:378	(4.64, -54.26, -16.30)
17:7948943		L>P	A:380	(3.46, -52.16, -8.14)
17:7948950		E>D	A:382	(0.56, -58.30, -11.48)
17:7948958	rs199631114	T>N	A:385	(-4.80, -57.28, -11.67)
17:7948973	rs368433235 COSM238762	R>H	A:390	(-7.25, -63.57, -4.53)
17:7948985		H>P	A:394	(-18.96, -59.51, -11.96)
17:7948992		H>Q	A:396	(-17.65, -54.14, -5.25)
17:7949996		P>L	A:404	(-11.69, -51.86, -17.28)
17:7950005		R>Q	A:407	(-8.82, -56.07, -20.89)
17:7950018		H>Q	A:411	(-0.96, -62.85, -21.24)
17:7950020		I>T	A:412	(2.40, -58.76, -20.76)
17:7950021	rs371467617	I>M	A:412	(2.40, -58.76, -20.76)
17:7950031		A>S	A:416	(7.92, -61.43, -18.81)
17:7950032	rs140152561	A>D	A:416	(7.92, -61.43, -18.81)
17:7950035	rs542223285	R>Q	A:417	(6.65, -63.87, -14.44)
17:7950046		I>L	A:421	(12.82, -61.76, -16.24)
17:7950049		V>M	A:422	(14.01, -66.37, -18.56)
17:7950052	rs201001210	P>T	A:423	(18.03, -67.97, -17.86)
17:7950237	rs148578247	G>S	A:434	(21.42, -58.27, -16.16)
17:7950240		I>V	A:435	(18.57, -62.21, -14.83)
17:7950245		E>D	A:436	(21.36, -61.12, -10.23)
17:7950263	rs199735812	I>M	A:442	(13.09, -55.08, -8.46)
17:7950265	rs146833910	Q>R	A:443	(15.83, -57.20, -4.00)
17:7950294		L>V	A:453	(7.44, -41.37, -5.28)
17:7950298		L>P	A:454	(3.06, -44.95, -6.43)
17:7950318	COSM273952	R>W	A:461	(3.77, -31.01, -2.29)
17:7950319	rs140623478	R>Q	A:461	(3.77, -31.01, -2.29)
17:7950325	rs200138131	R>Q	A:463	(10.27, -35.17, -8.48)
17:7950328		G>E	A:464	(9.97, -29.86, -6.30)
17:7950345		G>S	A:470	(8.87, -27.55, -20.28)
17:7950357		R>C	A:474	(5.05, -30.63, -14.74)
17:7950358	rs373235403	R>H	A:474	(5.05, -30.63, -14.74)
17:7950370		M>K	A:478	(-0.85, -32.79, -12.81)
17:7950382		G>D	A:482	(-7.27, -34.80, -12.51)
17:7950393	rs577207398 COSM1387571	R>C	A:486	(-14.74, -34.96, -10.98)
17:7950394	rs9895916	R>H	A:486	(-14.74, -34.96, -10.98)
17:7950581		V>A	A:488	(-12.17, -42.30, -8.99)
17:7950595	rs201760450	G>S	A:493	(-19.82, -40.62, -4.43)
17:7950596	rs561187104	G>D	A:493	(-19.82, -40.62, -4.43)
17:7950598		I>V	A:494	(-22.56, -42.66, -7.62)
17:7950611	rs187781490	S>I	A:498	(-20.22, -42.19, 4.63)
17:7950613		D>N	A:499	(-16.02, -41.91, 5.84)
17:7950620	rs201314484	S>F	A:501	(-19.63, -46.46, 4.09)
17:7950622		V>L	A:502	(-15.16, -46.44, 2.97)
17:7950637		E>K	A:507	(-15.40, -57.24, 0.08)
17:7950647		A>D	A:510	(-9.67, -57.48, 2.11)
17:7950661	rs200806151	I>F	A:515	(-2.84, -54.22, -2.87)
17:7950686		Q>R	A:523	(7.43, -52.70, 3.53)
17:7950688		E>K	A:524	(4.62, -49.52, 8.42)
17:7950692	rs141549870	S>N	A:525	(8.55, -47.71, 5.40)
17:7950905		R>W	A:535	(-16.39, -40.29, 1.36)
17:7950912		A>V	A:537	(-8.36, -42.19, 1.41)
17:7950921		Q>R	A:540	(-5.21, -40.47, -2.99)
17:7950930		T>I	A:543	(-6.83, -41.93, -8.61)
17:7950953		A>T	A:551	(-1.14, -42.85, -17.90)
17:7950962		A>T	A:554	(1.75, -44.89, -21.30)
17:7950963	rs200616718	A>V	A:554	(1.75, -44.89, -21.30)
17:7950974		A>T	A:558	(5.66, -44.65, -25.35)
17:7950978		G>A	A:559	(9.51, -43.76, -25.46)
17:7951065	rs371041493	F>L	A:561	(12.42, -47.47, -31.28)
17:7951089		N>K	A:569	(20.22, -41.66, -26.63)
17:7951096		P>S	A:572	(22.08, -51.43, -23.69)
17:7951101		S>R	A:573	(25.80, -52.26, -21.66)
17:7951141		C>R	A:587	(36.06, -41.44, -31.01)
17:7951142		C>Y	A:587	(36.06, -41.44, -31.01)
17:7951144		E>K	A:588	(39.29, -45.58, -30.90)
17:7951153	rs144680641	I>V	A:591	(33.11, -46.71, -30.95)
17:7951154		I>T	A:591	(33.11, -46.71, -30.95)
17:7951169		P>L	A:596	(28.39, -55.70, -28.01)
17:7951185		C>W	A:601	(20.81, -55.03, -32.35)
17:7951189	rs192653434	V>I	A:603	(18.39, -54.13, -26.14)
17:7951720	rs372796583	Y>C	A:623	(-14.37, -47.82, -19.85)
17:7951725		D>H	A:625	(-16.91, -54.19, -21.49)
17:7951735	rs117647130	F>Y	A:628	(-20.30, -49.20, -13.85)
17:7951750	rs199569625	P>L	A:633	(-22.47, -45.04, -13.04)
17:7951752	COSM4139951	R>W	A:634	(-23.71, -45.73, -18.82)
17:7951753	rs543494686	R>Q	A:634	(-23.71, -45.73, -18.82)
17:7951755	rs369665408	R>W	A:635	(-25.41, -39.40, -15.64)
17:7951756	rs61730298	R>Q	A:635	(-25.41, -39.40, -15.64)
17:7951759	rs117103775	S>N	A:636	(-19.35, -40.41, -14.44)
17:7951762		I>T	A:637	(-18.13, -43.74, -18.12)
17:7951764		A>T	A:638	(-19.60, -39.46, -20.39)
17:7951774	rs145203488	Q>R	A:641	(-15.32, -40.92, -22.23)
17:7951779	rs78119973	R>C	A:643	(-10.90, -32.83, -19.19)
17:7951783		L>R	A:644	(-9.54, -38.27, -21.16)
17:7951786	rs201814645	A>V	A:645	(-11.29, -35.31, -25.49)
17:7951795		S>W	A:648	(-6.29, -34.77, -26.37)
17:7951800		G>S	A:650	(-4.80, -29.45, -25.81)
17:7951801	rs200606322	G>D	A:650	(-4.80, -29.45, -25.81)
17:7951812		R>W	A:654	(1.73, -29.08, -25.72)
17:7951819	rs4792147	Q>R	A:656	(0.61, -27.16, -34.03)
17:7951822	rs149652899	G>D	A:657	(4.60, -25.61, -31.67)
17:7951837	rs144385683	Y>C	A:662	(5.40, -35.61, -24.00)
17:7951839	rs568227029	T>P	A:663	(3.17, -37.53, -28.40)
17:7951845	rs374735985	L>I	A:665	(1.05, -38.69, -21.00)
17:7951851	rs535418281	P>S	A:667	(-5.40, -38.88, -23.86)
17:7951854	rs557201032	P>T	A:668	(-5.97, -40.54, -27.80)
17:7951862	rs569202952	I>M	A:670	(-2.92, -43.16, -22.37)
17:7951864		E>G	A:671	(-3.91, -49.02, -23.36)
17:7951870		S>I	A:673	(-4.50, -51.85, -19.20)
17:7951872	rs201702180	V>I	A:674	(0.04, -52.60, -17.99)
17:7951878	rs7225107	I>V	A:676	(3.17, -54.35, -24.40)

4NRE.A | ALOX15B.

4NRE.A | ALOX15B

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:7942706	COSM179963	E>D	A:50	(-28.15, -59.20, -29.87)
17:7945784	COSM2805059	N>D	A:183	(-1.15, -58.54, -34.38)
17:7945809	COSM985863	A>V	A:191	(11.09, -57.82, -36.17)
17:7948185	COSM1182575	A>T	A:239	(18.85, -31.95, -20.05)
17:7950292	COSM226331	S>F	A:452	(4.23, -39.87, -2.31)
17:7951740	COSM3523637	E>K	A:630	(-26.39, -48.11, -12.57)
17:7951878	COSM148187	I>V	A:676	(3.17, -54.35, -24.40)