1HU3.A | EIF4G3

PDB ID	1hu3
HGNC Gene Label(s)	EIF4G3
Structure Name	middle domain of human eif4gii
Resolution	2.37Å
Reference	AUTH J.MARCOTRIGIANO,I.B.LOMAKIN,N.SONENBERG,AUTH 2 T.V.PESTOVA,C.U.HELLEN,S.K.BURLEYTITL A CONSERVED HEAT DOMAIN WITHIN EIF4G DIRECTSTITL 2 ASSEMBLY OF THE TRANSLATION INITIATION MACHINERY.REF MOL.CELL V. 7 193 2001REFN ISSN 1097-2765PMID 11172724DOI 10.1016/S1097-2765(01)00167-8

ExAC Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:21212714		P>S	A:746	(4.89, 27.27, 5.73)
1:21212711		E>K	A:747	(8.63, 25.18, 7.27)
1:21205968		Q>E	A:768	(33.55, 38.97, 9.11)
1:21205959	COSM239688 COSM239689	N>Y	A:771	(33.54, 38.28, 17.93)
1:21205910	rs142520007	R>Q	A:787	(16.44, 24.32, 7.47)
1:21205874		A>V	A:799	(34.76, 29.55, -0.64)
1:21205860		S>G	A:804	(41.08, 34.63, -0.16)
1:21205856	rs375841595	F>Y	A:805	(37.94, 36.51, 1.93)
1:21191709		R>Q	A:834	(33.07, 18.18, 13.34)
1:21191683		K>E	A:843	(32.61, 16.14, -2.80)
1:21191664		K>I	A:849	(37.89, 11.65, -9.54)
1:21191153		A>G	A:885	(40.79, 22.59, -11.97)
1:21191150		R>Q	A:886	(45.51, 21.98, -12.29)
1:21191148	rs141989247	R>W	A:887	(42.63, 26.64, -9.60)
1:21191138		I>T	A:890	(44.52, 25.54, -5.18)
1:21191099		K>R	A:903	(39.37, 20.67, 14.29)
1:21191015	COSM3934458 COSM3934457	R>H	A:931	(52.62, 28.79, 1.76)
1:21190991		D>G	A:939	(50.06, 18.23, 13.13)
1:21188822		R>C	A:948	(50.97, 8.10, 4.68)
1:21188795		E>K	A:957	(64.70, 15.02, -3.60)
1:21188770		T>I	A:965	(61.24, 23.35, -11.18)
1:21188767		S>L	A:966	(61.64, 27.10, -10.15)
1:21188755		R>Q	A:970	(64.81, 24.11, -7.19)
1:21188738		V>I	A:976	(59.57, 21.69, 3.75)
1:21187010	rs564405901	C>S	A:982	(64.80, 19.79, 11.84)
1:21187006	COSM182901 COSM182902	N>S	A:983	(62.71, 17.55, 14.33)

1HU3.A | EIF4G3.