Assessment of Structural Intolerance and Durability
General Structure Information 2krg SLC9A3R1 solution structure of human sodium/ hydrogen exchange regulatory factor 1(150-358) -1.0Å AUTH S.BHATTACHARYA,Z.DAI,J.LI,S.BAXTER,D.J.CALLAWAY,AUTH 2 D.COWBURN,Z.BUTITL A CONFORMATIONAL SWITCH IN THE SODIUM/ HYDROGENTITL 2 EXCHANGE REGULATORY FACTOR 1(NHERF1) CONTROLSTITL 3 AUTOINHIBITION AND COMPLEX FORMATION.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20042604DOI 10.1074/JBC.M109.074005 Variant Set Distributions Mapped Variants
General Structure Information 1×62 PDLIM1 solution structure of the lim domain of carboxyl terminal lim domain protein 1 -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE LIM DOMAIN OF CARBOXYLTITL 2 TERMINAL LIM DOMAIN PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1kgd CASK crystal structure of the guanylate kinase-like domain of human cask 1.31Å AUTH Y.LI,O.SPANGENBERG,I.PAARMANN,M.KONRAD,A.LAVIETITL STRUCTURAL BASIS FOR NUCLEOTIDE-DEPENDENTTITL 2 REGULATION OF MEMBRANE-ASSOCIATED GUANYLATETITL 3 KINASE-LIKE DOMAINS.REF J.BIOL.CHEM. V. 277 4159 2002REFN ISSN 0021-9258PMID 11729206DOI 10.1074/JBC.M110792200 Variant Set Distributions Mapped Variants
General Structure Information 4l3i PRC1 structure of the microtubule associated protein prc1 (protein regulator of cytokinesis 1) 3.6Å AUTH R.SUBRAMANIAN,S.C.TI,L.TAN,S.A.DARST,T.M.KAPOORTITL MARKING AND MEASURING SINGLE MICROTUBULES BY PRC1 ANDTITL 2 KINESIN-4.REF CELL(CAMBRIDGE,MASS.) V. 154 377 2013REFN ISSN 0092-8674PMID 23870126DOI 10.1016/J.CELL.2013.06.021 Variant Set Distributions Mapped Variants
General Structure Information 2as5 FOXP2 structure of the dna binding domains of nfat and foxp2 bound specifically to dna. 2.7Å AUTH Y.WU,M.BORDE,V.HEISSMEYER,M.FEUERER,A.D.LAPAN,AUTH 2 J.C.STROUD,D.L.BATES,L.GUO,A.HAN,S.F.ZIEGLER,AUTH 3 D.MATHIS,C.BENOIST,L.CHEN,A.RAOTITL FOXP3 CONTROLS REGULATORY T CELL FUNCTION THROUGHTITL 2 COOPERATION WITH NFAT.REF CELL(CAMBRIDGE,MASS.) V. 126 375 2006REFN ISSN 0092-8674PMID 16873067DOI 10.1016/J.CELL.2006.05.042 Variant Set Distributions Mapped Variants
General Structure Information 1ri9 FYB structure of a helically extended sh3 domain of the t cell adapter protein adap -1.0Å AUTH K.HEUER,M.KOFLER,G.LANGDON,K.THIEMKE,C.FREUNDTITL STRUCTURE OF A HELICALLY EXTENDED SH3 DOMAIN OFTITL 2 THE T CELL ADAPTER PROTEIN ADAP.REF STRUCTURE V. 12 603 2004REFN ISSN 0969-2126PMID 15062083DOI 10.1016/J.STR.2004.02.021 Variant Set Distributions Mapped Variants
General Structure Information 4f9a CDC7 human cdc7 kinase in complex with dbf4 and nucleotide 2.17Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1v1t SDCBP crystal structure of the pdz tandem of human syntenin in complex with tneykv peptide 1.8Å AUTH J.GREMBECKA,T.CIERPICKI,Y.DEVEDJIEV,U.DEREWENDA,AUTH 2 B.S.KANG,J.H.BUSHWELLER,Z.S.DEREWENDATITL THE BINDING OF THE PDZ TANDEM OF SYNTENIN TOTITL 2 TARGET PROTEINS.REF BIOCHEMISTRY V. 45 3674 2006REFN ISSN 0006-2960PMID 16533050DOI 10.1021/BI052225Y Variant Set Distributions Mapped Variants
General Structure Information 1q1z SULT2B1 crystal structure of human cholesterol sulfotransferase (sult2b1b) in the presence of pap 2.4Å AUTH K.A.LEE,H.FUDA,Y.C.LEE,M.NEGISHI,C.A.STROTT,AUTH 2 L.C.PEDERSENTITL CRYSTAL STRUCTURE OF HUMAN CHOLESTEROLTITL 2 SULFOTRANSFERASE (SULT2B1B) IN THE PRESENCE OFTITL 3 PREGNENOLONE AND 3-PHOSPHOADENOSINE 5-PHOSPHATE.TITL 4 RATIONALE FOR SPECIFICITY DIFFERENCES BETWEENTITL 5 PROTOTYPICAL SULT2A1 AND THE SULT2BG1 ISOFORMS.REF J.BIOL.CHEM. V. 278 […]
General Structure Information 1lcy HTRA2 crystal structure of the mitochondrial serine protease htra2 2.0Å AUTH W.LI,S.M.SRINIVASULA,J.CHAI,P.LI,J.W.WU,Z.ZHANG,E.S.ALNEMRI,AUTH 2 Y.SHITITL STRUCTURAL INSIGHTS INTO THE PRO-APOPTOTIC FUNCTION OFTITL 2 MITOCHONDRIAL SERINE PROTEASE HTRA2/OMI.REF NAT.STRUCT.BIOL. V. 9 436 2002REFN ISSN 1072-8368PMID 11967569DOI 10.1038/NSB795 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants