Assessment of Structural Intolerance and Durability
General Structure Information 3f1i HGS human escrt-0 core complex 2.3Å AUTH X.REN,D.P.KLOER,Y.C.KIM,R.GHIRLANDO,L.F.SAIDI,G.HUMMER,AUTH 2 J.H.HURLEYTITL HYBRID STRUCTURAL MODEL OF THE COMPLETE HUMAN ESCRT-0TITL 2 COMPLEX.REF STRUCTURE V. 17 406 2009REFN ISSN 0969-2126PMID 19278655DOI 10.1016/J.STR.2009.01.012 Variant Set Distributions Mapped Variants
General Structure Information 2x8a NVL human nuclear valosin containing protein like (nvl), c- terminal aaa-atpase domain 2.6Å AUTH M.MOCHE,P.SCHUETZ,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,I.JOHANSSON,A.KALLAS,AUTH 4 T.KARLBERG,T.KOTENYOVA,P.KRAULIS,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.SEHIC,M.I.SIPONEN,L.SVENSSON,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VANDENBERG,E.WAHLBERG,AUTH 7 J.WEIGELT,M.WELIN,M.WISNIEWSKA,H.SCHULERTITL HUMAN NUCLEAR VALOSIN CONTAINING PROTEIN LIKETITL 2 (NVL) , C-TERMINAL AAA-ATPASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jxb NCK2 structure of cd3epsilon-nck2 first sh3 domain complex -1.0Å AUTH K.TAKEUCHI,H.YANG,E.NG,S.Y.PARK,Z.Y.SUN,AUTH 2 E.L.REINHERZ,G.WAGNERTITL STRUCTURAL AND FUNCTIONAL EVIDENCE THAT NCKTITL 2 INTERACTION WITH CD3EPSILON REGULATES T-CELLTITL 3 RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 380 704 2008REFN ISSN 0022-2836PMID 18555270DOI 10.1016/J.JMB.2008.05.037 Variant Set Distributions Mapped Variants
General Structure Information 3l81 AP4M1 crystal structure of adaptor protein complex 4 (ap-4) mu4 subunit c- terminal domain, in complex with a sorting peptide from the amyloid precursor protein (app) 1.6Å AUTH P.V.BURGOS,G.A.MARDONES,A.L.ROJAS,L.L.DASILVA,Y.PRABHU,AUTH 2 J.H.HURLEY,J.S.BONIFACINOTITL SORTING OF THE ALZHEIMERS DISEASE AMYLOID PRECURSORTITL 2 PROTEIN MEDIATED BY THE AP-4 COMPLEX.REF DEV.CELL V. 18 425 2010REFN ISSN […]
General Structure Information 3t06 ARHGEF11 crystal structure of the dh/ph fragment of pdzrhogef with n-terminal regulatory elements in complex with human rhoa 2.84Å AUTH J.A.BIELNICKI,A.V.SHKUMATOV,U.DEREWENDA,A.V.SOMLYO,AUTH 2 D.I.SVERGUN,Z.S.DEREWENDATITL INSIGHTS INTO THE MOLECULAR ACTIVATION MECHANISM OF THETITL 2 RHOA-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR, PDZRHOGEF.REF J.BIOL.CHEM. V. 286 35163 2011REFN ISSN 0021-9258PMID 21816819DOI 10.1074/JBC.M111.270918 Variant Set Distributions Ripley’s […]
General Structure Information 4hpf KCNU1 structure of the human slo3 gating ring 3.4Å AUTH M.D.LEONETTI,P.YUAN,Y.HSIUNG,R.MACKINNONTITL FUNCTIONAL AND STRUCTURAL ANALYSIS OF THE HUMAN SLO3 PH- ANDTITL 2 VOLTAGE-GATED K+ CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 109 19274 2012REFN ISSN 0027-8424PMID 23129643DOI 10.1073/PNAS.1215078109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vif SOCS6 crystal structure of socs6 sh2 domain in complex with a c-kit phosphopeptide 1.45Å AUTH F.ZADJALI,A.C.W.PIKE,M.VESTERLUND,J.SUN,C.WU,S.S.LI,AUTH 2 L.RONNSTRAND,S.KNAPP,A.BULLOCK,A.FLORES-MORALESTITL STRUCTURAL BASIS FOR C-KIT INHIBITION BY THETITL 2 SUPPRESSOR OF CYTOKINE SIGNALING 6 (SOCS6)TITL 3 UBIQUITIN LIGASE.REF J.BIOL.CHEM. V. 286 480 2011REFN ISSN 0021-9258PMID 21030588DOI 10.1074/JBC.M110.173526 Variant Set Distributions Mapped Variants
General Structure Information 2lkn AIP solution structure of the ppiase domain of human aryl-hydrocarbon receptor-interacting protein (aip) -1.0Å AUTH M.LINNERT,Y.J.LIN,A.MANNS,K.HAUPT,A.K.PASCHKE,G.FISCHER,AUTH 2 M.WEIWAD,C.LUECKETITL THE FKBP-TYPE DOMAIN OF THE HUMAN ARYL HYDROCARBONTITL 2 RECEPTOR-INTERACTING PROTEIN REVEALS AN UNUSUAL HSP90TITL 3 INTERACTION.REF BIOCHEMISTRY V. 52 2097 2013REFN ISSN 0006-2960PMID 23418784DOI 10.1021/BI301649M Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4a63 TP73 crystal structure of the p73-aspp2 complex at 2.6a resolution 2.27Å AUTH P.CANNING,F.VON DELFT,A.N.BULLOCKTITL STRUCTURAL BASIS FOR ASPP2 RECOGNITION BY THE TUMORTITL 2 SUPPRESSOR P73.REF J.MOL.BIOL. V. 423 515 2012REFN ISSN 0022-2836PMID 22917970DOI 10.1016/J.JMB.2012.08.005 Variant Set Distributions Mapped Variants
General Structure Information 3bqr DAPK3 crystal structure of human death associated protein kinase 3 (dapk3) in complex with an imidazo-pyridazine ligand 1.75Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,O.FEDOROV,F.NIESEN,A.C.W.PIKE,AUTH 2 E.S.PILKA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3TITL 2 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]