Assessment of Structural Intolerance and Durability
General Structure Information 2csq RIMBP2 solution structure of the second sh3 domain of human rim- binding protein 2 -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OFTITL 2 HUMAN RIM-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4l3p TAB1 crystal structure of 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)- 1h-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine bound to tak1-tab1 2.68Å AUTH K.R.HORNBERGER,D.M.BERGER,A.P.CREW,H.DONG,A.KLEINBERG,AUTH 2 A.H.LI,M.R.MEDEIROS,M.J.MULVIHILL,K.SIU,J.TARRANT,J.WANG,AUTH 3 F.WENG,V.L.WILDE,M.ALBERTELLA,M.BITTNER,A.COOKE,M.J.GRAY,AUTH 4 P.MARESCA,E.MAY,P.MEYN,W.PEICK,D.ROMASHKO,M.TANOWITZ,B.TOKARTITL DISCOVERY AND OPTIMIZATION OF 7-AMINOFURO[2,3-C]PYRIDINETITL 2 INHIBITORS OF TAK1.REF BIOORG.MED.CHEM.LETT. V. 23 4517 2013REFN ISSN 0960-894XPMID 23850198DOI 10.1016/J.BMCL.2013.06.053 Variant Set Distributions Mapped Variants
General Structure Information 4og5 MEN1 human menin with bound inhibitor miv-5 1.63Å AUTH S.HE,T.J.SENTER,J.POLLOCK,C.HAN,S.K.UPADHYAY,T.PUROHIT,AUTH 2 R.D.GOGLIOTTI,C.W.LINDSLEY,T.CIERPICKI,S.R.STAUFFER,AUTH 3 J.GREMBECKATITL HIGH-AFFINITY SMALL-MOLECULE INHIBITORS OF THE MENIN-MIXEDTITL 2 LINEAGE LEUKEMIA (MLL) INTERACTION CLOSELY MIMIC A NATURALTITL 3 PROTEIN-PROTEIN INTERACTION.REF J.MED.CHEM. V. 57 1543 2014REFN ISSN 0022-2623PMID 24472025DOI 10.1021/JM401868D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4gyy OGT crystal structure of human o-glcnac transferase with udp-5sglcnac and a peptide substrate 1.85Å AUTH M.B.LAZARUS,J.JIANG,T.M.GLOSTER,W.F.ZANDBERG,G.E.WHITWORTH,AUTH 2 D.J.VOCADLO,S.WALKERTITL STRUCTURAL SNAPSHOTS OF THE REACTION COORDINATE FOR O-GLCNACTITL 2 TRANSFERASE.REF NAT.CHEM.BIOL. V. 8 966 2012REFN ISSN 1552-4450PMID 23103939DOI 10.1038/NCHEMBIO.1109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2a41 WIPF1 ternary complex of the wh2 domain of wip with actin-dnase i 2.6Å AUTH D.CHEREAU,F.KERFF,P.GRACEFFA,Z.GRABAREK,K.LANGSETMO,AUTH 2 R.DOMINGUEZTITL ACTIN-BOUND STRUCTURES OF WISKOTT-ALDRICH SYNDROME PROTEINTITL 2 (WASP)-HOMOLOGY DOMAIN 2 AND THE IMPLICATIONS FOR FILAMENTTITL 3 ASSEMBLYREF PROC.NATL.ACAD.SCI.USA V. 102 16644 2005REFN ISSN 0027-8424PMID 16275905DOI 10.1073/PNAS.0507021102 Variant Set Distributions Mapped Variants
General Structure Information 4bej DNM1L nucleotide-free dynamin 1-like protein (dnm1l, drp1, dlp1) 3.48Å AUTH C.FROHLICH,S.GRABIGER,D.SCHWEFEL,K.FAELBER,E.ROSENBAUM,AUTH 2 J.MEARS,O.ROCKS,O.DAUMKETITL STRUCTURAL INSIGHTS INTO OLIGOMERIZATION AND MITOCHONDRIALTITL 2 REMODELLING OF DYNAMIN 1-LIKE PROTEIN.REF EMBO J. V. 32 1280 2013REFN ISSN 0261-4189PMID 23584531DOI 10.1038/EMBOJ.2013.74 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4g8a TLR4 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4avx HGS hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1.68 a resolution 1.68Å AUTH E.WILLIAMS,P.CANNING,L.SHRESTHA,T.KROJER,M.VOLLMAR,A.SLOWEY,AUTH 2 S.CONWAY,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE TANDEM VHS AND FYVE DOMAINS OFTITL 2 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASETITL 3 SUBSTRATE (HGS-HRS) BOUND TO AN IP2 COMPOUND AT 1.68 […]
General Structure Information 2dk7 TCERG1 solution structure of ww domain in transcription elongation regulator 1 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF WW DOMAIN IN TRANSCRIPTIONTITL 2 ELONGATION REGULATOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x2l CUX2 solution structure of the cut domain of human homeobox protein cux-2 (cut-like 2) -1.0Å AUTH Y.O.KAMATARI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CUT DOMAIN OF HUMANTITL 2 HOMEOBOX PROTEIN CUX-2 (CUT-LIKE 2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants