Assessment of Structural Intolerance and Durability
General Structure Information 4dyl FES f-bar domain of human fes tyrosine kinase 2.18Å AUTH E.UGOCHUKWU,E.SALAH,J.ELKINS,A.BARR,T.KROJER,AUTH 2 FILIPPAKOPOULOS P.,J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,F.VON DELFT,S.KNAPP,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL F-BAR DOMAIN OF HUMAN FES TYROSINE KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2i5f PLEK crystal structure of the c-terminal ph domain of pleckstrin in complex with d-myo-ins(1,2,3,5,6)p5 1.35Å AUTH S.G.JACKSON,Y.ZHANG,R.J.HASLAM,M.S.JUNOPTITL STRUCTURAL ANALYSIS OF THE CARBOXY TERMINAL PHTITL 2 DOMAIN OF PLECKSTRIN BOUND TO D-MYO-INOSITOLTITL 3 1,2,3,5,6-PENTAKISPHOSPHATE.REF BMC STRUCT.BIOL. V. 7 80 2007REFN ESSN 1472-6807PMID 18034889DOI 10.1186/1472-6807-7-80 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1jr2 UROS structure of uroporphyrinogen iii synthase 1.84Å AUTH M.A.MATHEWS,H.L.SCHUBERT,F.G.WHITBY,K.J.ALEXANDER,AUTH 2 K.SCHADICK,H.A.BERGONIA,J.D.PHILLIPS,C.P.HILLTITL CRYSTAL STRUCTURE OF HUMAN UROPORPHYRINOGEN IIITITL 2 SYNTHASE.REF EMBO J. V. 20 5832 2001REFN ISSN 0261-4189PMID 11689424DOI 10.1093/EMBOJ/20.21.5832 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f8a GPX1 crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1 1.5Å AUTH K.L.KAVANAGH,C.JOHANSSON,C.SMEE,O.GILEADI,F.VON DELFT,AUTH 2 U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO GLYCINE MUTANT OFTITL 2 HUMAN GLUTATHIONE PEROXIDASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1slm MMP3 crystal structure of fibroblast stromelysin-1: the c-truncated human proenzyme 1.9Å AUTH J.W.BECKER,A.I.MARCY,L.L.ROKOSZ,M.G.AXEL,J.J.BURBAUM,AUTH 2 P.M.FITZGERALD,P.M.CAMERON,C.K.ESSER,W.K.HAGMANN,J.D.HERMES,AUTH 3 J.P.SPRINGERTITL STROMELYSIN-1: THREE-DIMENSIONAL STRUCTURE OF THE INHIBITEDTITL 2 CATALYTIC DOMAIN AND OF THE C-TRUNCATED PROENZYME.REF PROTEIN SCI. V. 4 1966 1995REFN ISSN 0961-8368PMID 8535233 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4mwt CTSA crystal structure of human ppca (trigonal crystal form 2) 3.85Å AUTH N.KOLLI,S.C.GARMANTITL PROTEOLYTIC ACTIVATION OF HUMAN CATHEPSIN A.REF J.BIOL.CHEM. V. 289 11592 2014REFN ISSN 0021-9258PMID 24599961DOI 10.1074/JBC.M113.524280 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3eqm CYP19A1 crystal structure of human placental aromatase cytochrome p450 in complex with androstenedione 2.9Å AUTH D.GHOSH,J.GRISWOLD,M.ERMAN,W.PANGBORNTITL STRUCTURAL BASIS FOR ANDROGEN SPECIFICITY AND OESTROGENTITL 2 SYNTHESIS IN HUMAN AROMATASE.REF NATURE V. 457 219 2009REFN ISSN 0028-0836PMID 19129847DOI 10.1038/NATURE07614 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2knc ITGA2B platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex -1.0Å AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 Variant Set Distributions Mapped Variants
General Structure Information 1jfn LPA solution structure of human apolipoprotein(a) kringle iv type 6 -1.0Å AUTH B.MADEREGGER,W.BERMEL,A.HRZENJAK,G.M.KOSTNER,AUTH 2 H.STERKTITL SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A)TITL 2 KRINGLE IV TYPE 6.REF BIOCHEMISTRY V. 41 660 2002REFN ISSN 0006-2960PMID 11781107DOI 10.1021/BI011430K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lmf C1S c1s cub1-egf-cub2 2.92Å AUTH U.VENKATRAMAN GIRIJA,A.R.GINGRAS,J.E.MARSHALL,R.PANCHAL,AUTH 2 M.A.SHEIKH,P.GAL,W.J.SCHWAEBLE,D.A.MITCHELL,P.C.MOODY,AUTH 3 R.WALLISTITL STRUCTURAL BASIS OF THE C1Q/C1S INTERACTION AND ITS CENTRALTITL 2 ROLE IN ASSEMBLY OF THE C1 COMPLEX OF COMPLEMENT ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 110 13916 2013REFN ISSN 0027-8424PMID 23922389DOI 10.1073/PNAS.1311113110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]