General Structure Information
| PDB ID | 4lmf |
| HGNC Gene Label(s) | C1S |
| Structure Name | c1s cub1-egf-cub2 |
| Resolution | 2.92Å |
| Reference | AUTH U.VENKATRAMAN GIRIJA,A.R.GINGRAS,J.E.MARSHALL,R.PANCHAL,AUTH 2 M.A.SHEIKH,P.GAL,W.J.SCHWAEBLE,D.A.MITCHELL,P.C.MOODY,AUTH 3 R.WALLISTITL STRUCTURAL BASIS OF THE C1Q/C1S INTERACTION AND ITS CENTRALTITL 2 ROLE IN ASSEMBLY OF THE C1 COMPLEX OF COMPLEMENT ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 110 13916 2013REFN ISSN 0027-8424PMID 23922389DOI 10.1073/PNAS.1311113110 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 276 |
| Number Of SNVs | 69 |
| Number Of Permutations | 54332 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.279 |
| p-value | 0.039 |
COSMIC
| Number Of Residues | 276 |
| Number Of SNVs | 4 |
| Number Of Permutations | 569 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.167 |
| p-value | 0.767 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | -0.263 |
| p-value | 0.501 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
