Assessment of Structural Intolerance and Durability
General Structure Information 4dqm RARA revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity 2.75Å AUTH S.WANG,Z.WANG,S.LIN,W.ZHENG,R.WANG,S.JIN,J.CHEN,L.JIN,Y.LITITL REVEALING A NATURAL MARINE PRODUCT AS A NOVEL AGONIST FORTITL 2 RETINOIC ACID RECEPTORS WITH A UNIQUE BINDING MODE ANDTITL 3 INHIBITORY EFFECTS ON CANCER CELLS.REF […]
General Structure Information 1z8d PYGM crystal structure of human muscle glycogen phosphorylase a with amp and glucose 2.3Å AUTH C.M.LUKACS,N.G.OIKONOMAKOS,R.L.CROWTHER,L.N.HONG,AUTH 2 R.U.KAMMLOTT,W.LEVIN,S.LI,C.M.LIU,D.LUCAS-MCGADY,AUTH 3 S.PIETRANICO,L.REIKTITL THE CRYSTAL STRUCTURE OF HUMAN MUSCLE GLYCOGEN PHOSPHORYLASETITL 2 A WITH BOUND GLUCOSE AND AMP: AN INTERMEDIATE CONFORMATIONTITL 3 WITH T-STATE AND R-STATE FEATURES.REF PROTEINS V. 63 1123 2006REFN ISSN 0887-3585PMID […]
General Structure Information 2iik ACAA1 crystal structure of human peroxisomal acetyl-coa acyl transferase 1 (acaa1) 2.55Å AUTH E.PAPAGRIGORIOU,C.JOHANSSON,C.SMEE,K.KAVANAGH,A.C.W.PIKE,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,O.GILEADI,AUTH 3 F.GORREC,C.UMEANO,F.VON DELFT,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL ACETYL-COA ACYLTITL 2 TRANSFERASE 1 (ACAA1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1ni6 HMOX1 comparisions of the heme-free and-bound crystal structures of human heme oxygenase-1 2.1Å AUTH L.LAD,D.J.SCHULLER,H.SHIMIZU,J.FRIEDMAN,H.LI,AUTH 2 P.R.ORTIZ DE MONTELLANO,T.L.POULOSTITL COMPARISON OF THE HEME-FREE AND -BOUND CRYSTALTITL 2 STRUCTURES OF HUMAN HEME OXYGENASE-1REF J.BIOL.CHEM. V. 278 7834 2003REFN ISSN 0021-9258PMID 12500973DOI 10.1074/JBC.M211450200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2l86 IAPP solution nmr structure of human amylin in sds micelles at ph 7.3 -1.0Å AUTH R.P.NANGA,J.R.BRENDER,S.VIVEKANANDAN,A.RAMAMOORTHYTITL STRUCTURE AND MEMBRANE ORIENTATION OF IAPP IN ITS NATIVELYTITL 2 AMIDATED FORM AT PHYSIOLOGICAL PH IN A MEMBRANE ENVIRONMENT.REF BIOCHIM.BIOPHYS.ACTA V.1808 2337 2011REFN ISSN 0006-3002PMID 21723249DOI 10.1016/J.BBAMEM.2011.06.012 Variant Set Distributions Mapped Variants
General Structure Information 1hve ANXA5 structural and electrophysiological analysis of annexin v mutants. mutagenesis of human annexin v, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter 2.3Å AUTH A.BURGER,D.VOGES,P.DEMANGE,C.R.PEREZ,R.HUBER,AUTH 2 R.BERENDESTITL STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OFTITL 2 ANNEXIN V […]
General Structure Information 2c01 RNASE2 crystal structures of eosinophil-derived neurotoxin in complex with the inhibitors 5-atp, ap3a, ap4a and ap5a 1.24Å AUTH M.D.BAKER,D.E.HOLLOWAY,G.J.SWAMINATHAN,K.R.ACHARYATITL CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVEDTITL 2 NEUROTOXIN (EDN) IN COMPLEX WITH THE INHIBITORSTITL 3 5- ATP, AP(3)A, AP(4)A, AND AP(5)A.REF BIOCHEMISTRY V. 45 416 2006REFN ISSN 0006-2960PMID 16401072DOI 10.1021/BI0518592 Variant Set Distributions Mapped […]
General Structure Information 3g0f KIT kit kinase domain mutant d816h in complex with sunitinib 2.6Å AUTH K.S.GAJIWALA,J.C.WU,J.CHRISTENSEN,G.D.DESHMUKH,AUTH 2 W.DIEHL,J.P.DINITTO,J.M.ENGLISH,M.J.GREIG,Y.A.HE,AUTH 3 S.L.JACQUES,E.A.LUNNEY,M.MCTIGUE,D.MOLINA,AUTH 4 T.QUENZER,P.A.WELLS,X.YU,Y.ZHANG,A.ZOU,M.R.EMMETT,AUTH 5 A.G.MARSHALL,H.M.ZHANG,G.D.DEMETRITITL KIT KINASE MUTANTS SHOW UNIQUE MECHANISMS OF DRUGTITL 2 RESISTANCE TO IMATINIB AND SUNITINIB INTITL 3 GASTROINTESTINAL STROMAL TUMOR PATIENTS.REF PROC.NATL.ACAD.SCI.USA V. 106 1542 2009REFN ISSN 0027-8424PMID 19164557DOI 10.1073/PNAS.0812413106 Variant […]
General Structure Information 3uf1 VIM crystal structure of vimentin (fragment 144-251) from homo sapiens, northeast structural genomics consortium target hr4796b 2.81Å AUTH A.AZIZ,J.F.HESS,M.S.BUDAMAGUNTA,J.C.VOSS,A.P.KUZIN,AUTH 2 Y.J.HUANG,R.XIAO,G.T.MONTELIONE,P.G.FITZGERALD,J.F.HUNTTITL THE STRUCTURE OF VIMENTIN LINKER 1 AND ROD 1B DOMAINSTITL 2 CHARACTERIZED BY SITE-DIRECTED SPIN-LABELING ELECTRONTITL 3 PARAMAGNETIC RESONANCE (SDSL-EPR) AND X-RAY CRYSTALLOGRAPHY.REF J.BIOL.CHEM. V. 287 28349 2012REFN ISSN 0021-9258PMID […]
General Structure Information 1il8 IL8 three-dimensional structure of interleukin 8 in solution -1.0Å AUTH G.M.CLORE,E.APPELLA,M.YAMADA,K.MATSUSHIMA,AUTH 2 A.M.GRONENBORNTITL THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 INTITL 2 SOLUTION.REF BIOCHEMISTRY V. 29 1689 1990REFN ISSN 0006-2960PMID 2184886DOI 10.1021/BI00459A004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants