General Structure Information
| PDB ID | 4dyl |
| HGNC Gene Label(s) | FES |
| Structure Name | f-bar domain of human fes tyrosine kinase |
| Resolution | 2.18Å |
| Reference | AUTH E.UGOCHUKWU,E.SALAH,J.ELKINS,A.BARR,T.KROJER,AUTH 2 FILIPPAKOPOULOS P.,J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,F.VON DELFT,S.KNAPP,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL F-BAR DOMAIN OF HUMAN FES TYROSINE KINASEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 375 |
| Number Of SNVs | 98 |
| Number Of Permutations | 84926 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.048 |
| p-value | 0.426 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 15:91428289 | rs370302986 | S>F | A:5 | (19.87, 2.25, 42.73) |
| 15:91428301 | S>N | A:9 | (20.17, -7.00, 45.53) | |
| 15:91428315 | rs117804206 | G>R | A:14 | (16.87, -12.12, 39.94) |
| 15:91428318 | V>L | A:15 | (14.70, -9.32, 38.86) | |
| 15:91428327 | rs28510611 | Q>K | A:18 | (13.42, -13.73, 35.94) |
| 15:91428336 | E>K | A:21 | (15.72, -15.47, 30.33) | |
| 15:91428348 | rs376111396 | R>C | A:25 | (10.95, -15.76, 27.00) |
| 15:91428349 | R>H | A:25 | (10.95, -15.76, 27.00) | |
| 15:91428360 | rs139960065 | G>R | A:29 | (8.97, -14.16, 18.63) |
| 15:91428361 | G>V | A:29 | (8.97, -14.16, 18.63) | |
| 15:91428363 | M>V | A:30 | (10.23, -10.28, 17.14) | |
| 15:91428376 | M>R | A:34 | (10.10, -10.88, 11.43) | |
| 15:91428384 | R>G | A:37 | (5.29, -10.24, 6.43) | |
| 15:91428391 | K>R | A:39 | (6.22, -18.36, 4.41) | |
| 15:91428411 | rs368643135 COSM966573 COSM966572 |
G>R | A:46 | (3.45, -16.44, -6.35) |
| 15:91428423 | H>D | A:50 | (-0.51, -18.61, -11.24) | |
| 15:91428477 | rs140249304 | P>S | A:68 | (-7.67, 0.96, -26.08) |
| 15:91428645 | W>G | A:73 | (-5.78, -6.93, -19.08) | |
| 15:91428672 | G>S | A:82 | (5.71, -6.13, -10.34) | |
| 15:91428681 | rs56041861 | R>C | A:85 | (8.87, -8.50, -10.13) |
| 15:91428682 | R>H | A:85 | (8.87, -8.50, -10.13) | |
| 15:91428686 | L>F | A:86 | (8.21, -5.39, -4.79) | |
| 15:91428690 | R>W | A:88 | (10.26, -12.03, -5.38) | |
| 15:91428691 | COSM4057926 COSM4057925 |
R>Q | A:88 | (10.26, -12.03, -5.38) |
| 15:91428699 | A>T | A:91 | (11.39, -11.29, 1.54) | |
| 15:91428714 | S>T | A:96 | (19.07, -9.96, 4.76) | |
| 15:91428728 | S>R | A:100 | (19.84, -11.07, 10.60) | |
| 15:91428732 | L>V | A:102 | (16.56, -10.31, 15.75) | |
| 15:91428747 | rs544318873 | R>W | A:107 | (23.40, -14.39, 20.51) |
| 15:91428748 | R>Q | A:107 | (23.40, -14.39, 20.51) | |
| 15:91428753 | R>W | A:109 | (20.09, -10.19, 24.89) | |
| 15:91428754 | rs145079846 | R>Q | A:109 | (20.09, -10.19, 24.89) |
| 15:91428760 | rs535474019 | Q>R | A:111 | (26.48, -14.38, 26.20) |
| 15:91428765 | R>C | A:113 | (23.24, -13.99, 30.46) | |
| 15:91428778 | S>N | A:117 | (26.08, -14.39, 36.04) | |
| 15:91428794 | Q>H | A:122 | (33.56, -13.48, 39.74) | |
| 15:91428806 | E>D | A:126 | (35.69, -11.80, 46.46) | |
| 15:91430207 | I>T | A:135 | (37.93, -11.92, 59.21) | |
| 15:91430240 | rs201938748 | A>V | A:146 | (45.39, -15.86, 73.86) |
| 15:91430242 | R>W | A:147 | (45.03, -19.03, 75.36) | |
| 15:91430245 | D>N | A:148 | (49.27, -20.01, 74.35) | |
| 15:91430257 | A>T | A:152 | (52.24, -18.99, 79.77) | |
| 15:91430258 | A>D | A:152 | (52.24, -18.99, 79.77) | |
| 15:91430263 | COSM1206996 | R>C | A:154 | (48.47, -20.52, 85.53) |
| 15:91430264 | rs372642630 COSM966577 COSM966576 |
R>H | A:154 | (48.47, -20.52, 85.53) |
| 15:91430433 | COSM4151203 COSM4151202 |
K>N | A:167 | (61.87, -21.09, 80.73) |
| 15:91430438 | K>R | A:169 | (59.72, -16.37, 80.61) | |
| 15:91430452 | rs201771040 COSM1375475 COSM1375474 |
R>C | A:174 | (59.35, -17.37, 72.77) |
| 15:91430465 | K>R | A:178 | (53.26, -14.81, 68.44) | |
| 15:91430467 | L>I | A:179 | (49.24, -12.22, 70.76) | |
| 15:91430474 | rs373485327 | A>G | A:181 | (51.66, -9.99, 65.53) |
| 15:91430479 | H>Y | A:183 | (46.41, -7.11, 67.38) | |
| 15:91430485 | rs138511924 | R>C | A:185 | (47.22, -8.82, 61.21) |
| 15:91430497 | G>S | A:189 | (42.18, -7.09, 57.86) | |
| 15:91430504 | R>Q | A:191 | (40.38, -0.32, 57.24) | |
| 15:91430510 | A>V | A:193 | (37.44, -5.70, 54.82) | |
| 15:91430525 | rs145301509 | Q>R | A:198 | (33.64, 1.23, 51.02) |
| 15:91430536 | Q>E | A:202 | (29.97, 2.66, 47.55) | |
| 15:91430551 | COSM4057930 COSM4057929 |
G>S | A:207 | (28.82, -0.88, 37.97) |
| 15:91430552 | rs377603197 | G>D | A:207 | (28.82, -0.88, 37.97) |
| 15:91430560 | R>W | A:210 | (25.30, 1.38, 34.95) | |
| 15:91430578 | H>Y | A:216 | (19.82, -4.38, 28.46) | |
| 15:91430593 | C>S | A:221 | (18.21, 1.30, 20.07) | |
| 15:91432544 | I>T | A:226 | (15.31, -4.35, 14.17) | |
| 15:91432569 | S>R | A:234 | (6.98, -4.58, 4.96) | |
| 15:91432576 | rs138932852 | V>M | A:237 | (2.08, 2.01, 1.70) |
| 15:91432582 | D>H | A:239 | (7.20, 5.44, -2.68) | |
| 15:91432591 | V>M | A:242 | (2.20, 4.10, -4.80) | |
| 15:91432595 | rs143351963 | A>V | A:243 | (3.89, 3.60, -8.46) |
| 15:91432603 | rs141047785 | R>W | A:246 | (0.19, 6.69, -8.58) |
| 15:91432604 | rs34573430 | R>Q | A:246 | (0.19, 6.69, -8.58) |
| 15:91432607 | E>V | A:247 | (1.09, 3.44, -13.97) | |
| 15:91432611 | M>I | A:248 | (-2.54, -0.24, -12.12) | |
| 15:91432627 | rs149847085 | R>C | A:254 | (-4.88, 5.57, -20.29) |
| 15:91432628 | rs145351114 | R>H | A:254 | (-4.88, 5.57, -20.29) |
| 15:91432655 | G>V | A:263 | (-8.62, 0.46, -35.30) | |
| 15:91432660 | L>V | A:265 | (-13.17, 0.08, -38.11) | |
| 15:91432664 | R>Q | A:266 | (-8.42, 3.21, -38.25) | |
| 15:91432668 | Q>H | A:267 | (-6.91, -3.83, -39.44) | |
| 15:91432751 | COSM3817066 COSM3817065 |
A>T | A:271 | (-16.79, -0.87, -48.74) |
| 15:91432755 | P>L | A:272 | (-20.22, -1.00, -48.66) | |
| 15:91432757 | D>N | A:273 | (-21.39, -5.76, -50.64) | |
| 15:91432776 | T>M | A:279 | (-33.97, -4.33, -63.38) | |
| 15:91432814 | E>K | A:292 | (-42.45, 0.31, -71.49) | |
| 15:91432816 | E>D | A:292 | (-42.45, 0.31, -71.49) | |
| 15:91432818 | rs188344412 | P>H | A:293 | (-39.32, -0.13, -69.88) |
| 15:91432821 | G>E | A:294 | (-41.72, -1.42, -66.55) | |
| 15:91432856 | rs373788500 | V>M | A:306 | (-55.28, -2.38, -62.06) |
| 15:91432866 | rs368178849 | T>M | A:309 | (-54.24, -4.57, -57.40) |
| 15:91433093 | L>P | A:317 | (-50.21, 0.38, -47.04) | |
| 15:91433098 | V>M | A:319 | (-52.00, -3.52, -42.23) | |
| 15:91433104 | rs201729285 | T>S | A:321 | (-49.07, 1.84, -41.57) |
| 15:91433105 | T>I | A:321 | (-49.07, 1.84, -41.57) | |
| 15:91433122 | rs199975821 | R>W | A:327 | (-43.28, -2.50, -34.42) |
| 15:91433123 | rs144946287 | R>Q | A:327 | (-43.28, -2.50, -34.42) |
| 15:91433138 | rs149066819 | T>M | A:332 | (-41.34, 4.75, -27.31) |
| 15:91433146 | Q>K | A:335 | (-36.55, 4.38, -25.98) | |
| 15:91433159 | COSM966586 COSM966585 |
R>Q | A:339 | (-34.06, 6.38, -19.44) |
| 15:91433167 | rs376898394 | E>K | A:342 | (-29.95, 4.58, -17.93) |
| 15:91433170 | COSM3887791 COSM3887790 |
E>Q | A:343 | (-31.45, 7.56, -13.87) |
| 15:91433171 | rs139208515 | E>G | A:343 | (-31.45, 7.56, -13.87) |
| 15:91433175 | N>K | A:344 | (-32.72, 4.99, -11.08) | |
| 15:91433177 | T>I | A:345 | (-28.59, 2.62, -12.44) | |
| 15:91433185 | rs371311890 | R>W | A:348 | (-18.65, 0.92, -10.52) |
| 15:91433186 | R>Q | A:348 | (-18.65, 0.92, -10.52) | |
| 15:91433191 | COSM4057939 COSM4057938 |
R>W | A:350 | (-24.63, 1.02, -17.20) |
| 15:91433386 | C>S | A:372 | (-39.43, -2.32, -45.69) | |
| 15:91433407 | A>T | A:379 | (-44.32, 1.71, -54.43) | |
| 15:91433438 | E>G | A:389 | (-54.70, 8.87, -63.22) | |
| 15:91433447 | G>V | A:392 | (-59.10, 8.62, -66.41) | |
| 15:91433452 | G>S | A:394 | (-60.73, 7.13, -70.30) | |
| 15:91433455 | COSM3794519 COSM3794518 |
E>K | A:395 | (-61.11, 4.67, -72.63) |
| 15:91433461 | P>S | A:397 | (-56.82, 1.08, -74.09) | |
| 15:91433464 | P>S | A:398 | (-58.30, -0.90, -77.41) |