General Structure Information
| PDB ID | 3eqm |
| HGNC Gene Label(s) | CYP19A1 |
| Structure Name | crystal structure of human placental aromatase cytochrome p450 in complex with androstenedione |
| Resolution | 2.9Å |
| Reference | AUTH D.GHOSH,J.GRISWOLD,M.ERMAN,W.PANGBORNTITL STRUCTURAL BASIS FOR ANDROGEN SPECIFICITY AND OESTROGENTITL 2 SYNTHESIS IN HUMAN AROMATASE.REF NATURE V. 457 219 2009REFN ISSN 0028-0836PMID 19129847DOI 10.1038/NATURE07614 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 452 |
| Number Of SNVs | 124 |
| Number Of Permutations | 23618 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.077 |
| p-value | 0.846 |
ClinVar
| Number Of Residues | 452 |
| Number Of SNVs | 5 |
| Number Of Permutations | 652 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.2 |
| p-value | 0.072 |
COSMIC
| Number Of Residues | 452 |
| Number Of SNVs | 8 |
| Number Of Permutations | 5761 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.321 |
| p-value | 0.948 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 124 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.173 |
| p-value | 0.076 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 124 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | -0.189 |
| p-value | 0.618 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
