Assessment of Structural Intolerance and Durability
General Structure Information 3zfm EPHB2 crystal structure of ephb2 2.27Å AUTH R.C.OVERMAN,J.E.DEBRECZENI,C.M.TRUMAN,M.S.MCALISTER,AUTH 2 T.K.ATTWOODTITL COMPLETING THE STRUCTURAL FAMILY PORTRAIT OF THE HUMAN EPHBTITL 2 TYROSINE KINASE DOMAINSREF PROTEIN SCI. V. 23 627 2014REFN ISSN 0961-8368PMID 24677421DOI 10.1002/PRO.2445 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pvy FGFR2 crystal strucure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k659n mutation responsible for an unclassified craniosynostosis syndrome. 2.2Å AUTH H.CHEN,J.MA,W.LI,A.V.ELISEENKOVA,C.XU,T.A.NEUBERT,AUTH 2 W.T.MILLER,M.MOHAMMADITITL A MOLECULAR BRAKE IN THE KINASE HINGE REGION REGULATES THETITL 2 ACTIVITY OF RECEPTOR TYROSINE KINASES.REF MOL.CELL V. 27 717 2007REFN ISSN 1097-2765PMID 17803937DOI 10.1016/J.MOLCEL.2007.06.028 […]
General Structure Information 4h1y NT5E human ecto-5-nucleotidase (cd73): crystal form ii (open) in complex with psb11552 1.58Å AUTH K.KNAPP,M.ZEBISCH,J.PIPPEL,A.EL-TAYEB,C.E.MULLER,N.STRATERTITL CRYSTAL STRUCTURE OF THE HUMAN ECTO-5-NUCLEOTIDASE (CD73):TITL 2 INSIGHTS INTO THE REGULATION OF PURINERGIC SIGNALING.REF STRUCTURE V. 20 2161 2012REFN ISSN 0969-2126PMID 23142347DOI 10.1016/J.STR.2012.10.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jxh PTPRG ca-like domain of human ptprg 1.7Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1d4u XPA interactions of human nucleotide excision repair protein xpa with rpa70 and dna: chemical shift mapping and 15n nmr relaxation studies -1.0Å AUTH G.W.BUCHKO,G.W.DAUGHDRILL,R.DE LORIMIER,K.RAO B,AUTH 2 N.G.ISERN,J.M.LINGBECK,J.S.TAYLOR,M.S.WOLD,AUTH 3 M.GOCHIN,L.D.SPICER,D.F.LOWRY,M.A.KENNEDYTITL INTERACTIONS OF HUMAN NUCLEOTIDE EXCISION REPAIRTITL 2 PROTEIN XPA WITH DNA AND RPA70 DELTA C327:TITL 3 CHEMICAL SHIFT MAPPING AND 15N […]
General Structure Information 1×80 BCKDHB crystal structure of the human mitochondrial branched-chain alpha- ketoacid dehydrogenase 2.0Å AUTH R.M.WYNN,M.KATO,M.MACHIUS,J.L.CHUANG,J.LI,D.R.TOMCHICK,AUTH 2 D.T.CHUANGTITL MOLECULAR MECHANISM FOR REGULATION OF THE HUMANTITL 2 MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASETITL 3 COMPLEX BY PHOSPHORYLATIONREF STRUCTURE V. 12 2185 2004REFN ISSN 0969-2126PMID 15576032DOI 10.1016/J.STR.2004.09.013 Variant Set Distributions Mapped Variants
General Structure Information 2irw HSD11B1 human 11-beta-hydroxysteroid dehydrogenase (hsd1) with nadp and adamantane ether inhibitor 3.1Å AUTH J.R.PATEL,Q.SHUAI,J.DINGES,M.WINN,M.PLIUSHCHEV,S.FUNG,AUTH 2 K.MONZON,W.CHIOU,J.WANG,L.PAN,S.WAGAW,K.ENGSTROM,AUTH 3 F.A.KERDESKY,K.LONGENECKER,R.JUDGE,W.QIN,H.M.IMADE,AUTH 4 D.STOLARIK,D.W.BENO,M.BRUNE,L.E.CHOVAN,H.L.SHAM,P.JACOBSON,AUTH 5 J.T.LINKTITL DISCOVERY OF ADAMANTANE ETHERS AS INHIBITORS OFTITL 2 11BETA-HSD-1: SYNTHESIS AND BIOLOGICAL EVALUATION.REF BIOORG.MED.CHEM.LETT. V. 17 750 2007REFN ISSN 0960-894XPMID 17110106DOI 10.1016/J.BMCL.2006.10.074 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2qbx EPHB2 ephb2/snew antagonistic peptide complex 2.3Å AUTH J.E.CHRENCIK,A.BROOUN,M.I.RECHT,G.NICOLA,L.K.DAVIS,AUTH 2 R.ABAGYAN,H.WIDMER,E.B.PASQUALE,P.KUHNTITL THREE-DIMENSIONAL STRUCTURE OF THE EPHB2 RECEPTORTITL 2 IN COMPLEX WITH AN ANTAGONISTIC PEPTIDE REVEALS ATITL 3 NOVEL MODE OF INHIBITION.REF J.BIOL.CHEM. V. 282 36505 2007REFN ISSN 0021-9258PMID 17897949DOI 10.1074/JBC.M706340200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4g6l CCNC crystal structure of human cdk8/cycc in the dmg-in conformation 2.7Å AUTH E.V.SCHNEIDER,J.BOTTCHER,R.HUBER,K.MASKOS,L.NEUMANNTITL STRUCTURE-KINETIC RELATIONSHIP STUDY OF CDK8/CYCC SPECIFICTITL 2 COMPOUNDS.REF PROC.NATL.ACAD.SCI.USA V. 110 8081 2013REFN ISSN 0027-8424PMID 23630251DOI 10.1073/PNAS.1305378110 Variant Set Distributions Mapped Variants
General Structure Information 3tk9 GZMH crystal structure of human granzyme h 2.2Å AUTH L.WANG,K.ZHANG,L.WU,S.LIU,H.ZHANG,Q.ZHOU,L.TONG,F.SUN,Z.FANTITL STRUCTURAL INSIGHTS INTO THE SUBSTRATE SPECIFICITY OF HUMANTITL 2 GRANZYME H: THE FUNCTIONAL ROLES OF A NOVEL RKR MOTIFREF J.IMMUNOL. V. 188 765 2012REFN ISSN 0022-1767PMID 22156497DOI 10.4049/JIMMUNOL.1101381 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants