Assessment of Structural Intolerance and Durability
General Structure Information 2jxj KDM5A nmr structure of the arid domain from the histone h3k4 demethylase rbp2 -1.0Å AUTH S.TU,Y.C.TENG,C.YUAN,Y.T.WU,M.Y.CHAN,A.N.CHENG,AUTH 2 P.H.LIN,L.J.JUAN,M.D.TSAITITL THE ARID DOMAIN OF THE H3K4 DEMETHYLASE RBP2 BINDSTITL 2 TO A DNA CCGCCC MOTIFREF NAT.STRUCT.MOL.BIOL. V. 15 419 2008REFN ISSN 1545-9993PMID 18270511DOI 10.1038/NSMB.1400 Variant Set Distributions Mapped Variants
General Structure Information 4asx ACVR2A crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dihydro-bauerine c 2.05Å AUTH E.WILLIAMS,A.CHAIKUAD,P.CANNING,P.MAHAJAN,C.D.O.COOPER,AUTH 2 A.BELTRAMI,T.KROJER,K.HUBER,F.BRACHER,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA ( ACVR2A)TITL 2 KINASE DOMAIN IN COMPLEX WITH A BETA- CARBOLINE INHIBITORREF TO BE PUBLISHED Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bic MUT crystal structure of human methylmalonyl-coa mutase 2.6Å AUTH D.S.FROESE,G.KOCHAN,J.R.MUNIZ,X.WU,C.GILEADI,E.UGOCHUKWU,AUTH 2 E.KRYSZTOFINSKA,R.A.GRAVEL,U.OPPERMANN,W.W.YUETITL STRUCTURES OF THE HUMAN GTPASE MMAA AND VITAMINTITL 2 B12-DEPENDENT METHYLMALONYL-COA MUTASE AND INSIGHT INTOTITL 3 THEIR COMPLEX FORMATION.REF J.BIOL.CHEM. V. 285 38204 2010REFN ISSN 0021-9258PMID 20876572DOI 10.1074/JBC.M110.177717 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1e5w MSN structure of isolated ferm domain and first long helix of moesin 2.7Å AUTH S.D.EDWARDS,N.H.KEEPTITL THE 2.7 A CRYSTAL STRUCTURE OF THE ACTIVATED FERMTITL 2 DOMAIN OF MOESIN: AN ANALYSIS OF STRUCTURALTITL 3 CHANGES ON ACTIVATIONREF BIOCHEMISTRY V. 40 7061 2001REFN ISSN 0006-2960PMID 11401550DOI 10.1021/BI010419H Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4l23 PIK3R1 crystal structure of p110alpha complexed with nish2 of p85alpha and pi-103 2.5Å AUTH Y.ZHAO,X.ZHANG,Y.CHEN,S.LU,Y.PENG,X.WANG,C.GUO,A.ZHOU,AUTH 2 J.ZHANG,Y.LUO,Q.SHEN,J.DING,L.MENG,J.ZHANGTITL CRYSTAL STRUCTURES OF PI3K ALPHA COMPLEXED WITH PI103 ANDTITL 2 ITS DERIVATIVES: NEW DIRECTIONS FOR INHIBITORS DESIGN.REF ACS MED CHEM LETT V. 5 138 2014REFN ISSN 1948-5875PMID 24900786DOI 10.1021/ML400378E Variant Set Distributions Ripley’s K […]
General Structure Information 3kka EPHA1 co-crystal structure of the sam domains of epha1 and epha2 2.4Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL CO-CRYSTAL STRUCTURE OF THE SAM DOMAINS OF HUMANTITL 2 EPHRIN TYPE-A RECEPTOR 1 AND HUMAN EPHRIN TYPE-ATITL 3 RECEPTOR 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1nfi NFKBIA i-kappa-b-alpha/nf-kappa-b complex 2.7Å AUTH M.D.JACOBS,S.C.HARRISONTITL STRUCTURE OF AN IKAPPABALPHA/NF-KAPPAB COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 95 749 1998REFN ISSN 0092-8674PMID 9865693DOI 10.1016/S0092-8674(00)81698-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4l01 JAK1 crystal structure of the v658f apo jak1 pseudokinase domain 1.9Å AUTH A.V.TOMS,A.DESHPANDE,R.MCNALLY,Y.JEONG,J.M.ROGERS,C.U.KIM,AUTH 2 S.M.GRUNER,S.B.FICARRO,J.A.MARTO,M.SATTLER,J.D.GRIFFIN,AUTH 3 M.J.ECKTITL STRUCTURE OF A PSEUDOKINASE-DOMAIN SWITCH THAT CONTROLSTITL 2 ONCOGENIC ACTIVATION OF JAK KINASES.REF NAT.STRUCT.MOL.BIOL. V. 20 1221 2013REFN ISSN 1545-9993PMID 24013208DOI 10.1038/NSMB.2673 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1nf1 NF1 the gap related domain of neurofibromin 2.5Å AUTH K.SCHEFFZEK,M.R.AHMADIAN,L.WIESMULLER,W.KABSCH,AUTH 2 P.STEGE,F.SCHMITZ,A.WITTINGHOFERTITL STRUCTURAL ANALYSIS OF THE GAP-RELATED DOMAIN FROMTITL 2 NEUROFIBROMIN AND ITS IMPLICATIONS.REF EMBO J. V. 17 4313 1998REFN ISSN 0261-4189PMID 9687500DOI 10.1093/EMBOJ/17.15.4313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mil SHC1 transforming protein 2.7Å AUTH V.MIKOL,G.BAUMANN,M.G.ZURINI,U.HOMMELTITL CRYSTAL STRUCTURE OF THE SH2 DOMAIN FROM THETITL 2 ADAPTOR PROTEIN SHC: A MODEL FOR PEPTIDE BINDINGTITL 3 BASED ON X-RAY AND NMR DATA.REF J.MOL.BIOL. V. 254 86 1995REFN ISSN 0022-2836PMID 7473762DOI 10.1006/JMBI.1995.0601 Variant Set Distributions Mapped Variants