Assessment of Structural Intolerance and Durability
General Structure Information 1x5o RBMS1 solution structure of rrm domain in rna binding motif, single-stranded interacting protein 1 -1.0Å AUTH W.DANG,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF RRM DOMAIN IN RNA BINDINGTITL 2 MOTIF, SINGLE-STRANDED INTERACTING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4l45 RPS6KB1 crystal structures of human p70s6k1-t389e 2.9Å AUTH J.WANG,C.ZHONG,F.WANG,F.QU,J.DINGTITL CRYSTAL STRUCTURES OF S6K1 PROVIDE INSIGHTS INTO THETITL 2 REGULATION MECHANISM OF S6K1 BY THE HYDROPHOBIC MOTIFREF BIOCHEM.J. V. 454 39 2013REFN ISSN 0264-6021PMID 23731517DOI 10.1042/BJ20121863 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3cnk FLNA crystal structure of the dimerization domain of human filamin a 1.65Å AUTH M.-D.SEO,S.-H.SEOK,H.IM,A.-R.KWON,S.-J.LEE,AUTH 2 H.-R.KIM,Y.CHO,D.PARK,B.-J.LEETITL CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OFTITL 2 HUMAN FILAMIN AREF PROTEINS V. 75 258 2008REFN ISSN 0887-3585PMID 19137608DOI 10.1002/PROT.22336 Variant Set Distributions Mapped Variants
General Structure Information 3cmy PAX3 structure of a homeodomain in complex with dna 1.95Å AUTH G.BIRRANE,A.SONI,J.A.LADIASTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY THE HUMAN PAX3TITL 2 HOMEODOMAIN.REF BIOCHEMISTRY V. 48 1148 2009REFN ISSN 0006-2960PMID 19199574DOI 10.1021/BI802052Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v2w S1PR1 crystal structure of a lipid g protein-coupled receptor at 3.35a 3.35Å AUTH M.A.HANSON,C.B.ROTH,E.JO,M.T.GRIFFITH,F.L.SCOTT,G.REINHART,AUTH 2 H.DESALE,B.CLEMONS,S.M.CAHALAN,S.C.SCHUERER,M.G.SANNA,AUTH 3 G.W.HAN,P.KUHN,H.ROSEN,R.C.STEVENSTITL CRYSTAL STRUCTURE OF A LIPID G PROTEIN-COUPLED RECEPTOR.REF SCIENCE V. 335 851 2012REFN ISSN 0036-8075PMID 22344443DOI 10.1126/SCIENCE.1215904 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4leo ERBB3 crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3) 2.64Å AUTH C.MIRSCHBERGER,C.B.SCHILLER,M.SCHRAML,N.DIMOUDIS,T.FRIESS,AUTH 2 C.A.GERDES,U.REIFF,V.LIFKE,G.HOELZLWIMMER,I.KOLM,AUTH 3 K.P.HOPFNER,G.NIEDERFELLNER,B.BOSSENMAIERTITL RG7116, A THERAPEUTIC ANTIBODY THAT BINDS THE INACTIVE HER3TITL 2 RECEPTOR AND IS OPTIMIZED FOR IMMUNE EFFECTOR ACTIVATION.REF CANCER RES. V. 73 5183 2013REFN ISSN 0008-5472PMID 23780344DOI […]
General Structure Information 4fv2 MAPK1 crystal structure of the erk2 complexed with ek5 2.0Å AUTH Y.N.KANG,J.A.STUCKEY,X.XIETITL CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1hdj DNAJB1 human hsp40 (hdj-1), nmr -1.0Å AUTH Y.Q.QIAN,D.PATEL,F.U.HARTL,D.J.MCCOLLTITL NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OFTITL 2 THE HUMAN HSP40 (HDJ-1) J-DOMAIN.REF J.MOL.BIOL. V. 260 224 1996REFN ISSN 0022-2836PMID 8764402DOI 10.1006/JMBI.1996.0394 Variant Set Distributions Mapped Variants
General Structure Information 3bwy COMT crystal structure of human 108m catechol o- methyltransferase bound with s-adenosylmethionine and inhibitor dinitrocatechol 1.3Å AUTH K.RUTHERFORD,I.LE TRONG,R.E.STENKAMP,W.W.PARSONTITL CRYSTAL STRUCTURES OF HUMAN 108V AND 108M CATECHOLTITL 2 O-METHYLTRANSFERASE.REF J.MOL.BIOL. V. 380 120 2008REFN ISSN 0022-2836PMID 18486144DOI 10.1016/J.JMB.2008.04.040 Variant Set Distributions Mapped Variants
General Structure Information 2hev TNFSF4 crystal structure of the complex between ox40l and ox40 2.41Å AUTH D.M.COMPAAN,S.G.HYMOWITZTITL THE CRYSTAL STRUCTURE OF THE COSTIMULATORY OX40-OX40LTITL 2 COMPLEX.REF STRUCTURE V. 14 1321 2006REFN ISSN 0969-2126PMID 16905106DOI 10.1016/J.STR.2006.06.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants