Assessment of Structural Intolerance and Durability
General Structure Information 4dx1 TRPV4 crystal structure of the human trpv4 ankyrin repeat domain 2.85Å AUTH H.INADA,E.PROCKO,M.SOTOMAYOR,R.GAUDETTITL STRUCTURAL AND BIOCHEMICAL CONSEQUENCES OF DISEASE-CAUSINGTITL 2 MUTATIONS IN THE ANKYRIN REPEAT DOMAIN OF THE HUMAN TRPV4TITL 3 CHANNEL.REF BIOCHEMISTRY V. 51 6195 2012REFN ISSN 0006-2960PMID 22702953DOI 10.1021/BI300279B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2al7 ARL8B structure of human adp-ribosylation factor-like 10c 1.85Å AUTH S.ISMAIL,S.DIMOV,A.ATANASSOVA,C.ARROWSMITH,AUTH 2 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARK,AUTH 3 STRUCTURAL GENOMICS CONSORTIUMTITL GTP-LIKE CONFORMATION OF GDP-BOUND ARL10C GTPASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fm8 KIF13B crystal structure of full length centaurin alpha-1 bound with the fha domain of kif13b (capri target) 2.3Å AUTH Y.TONG,W.TEMPEL,H.WANG,K.YAMADA,L.SHEN,G.A.SENISTERRA,AUTH 2 F.MACKENZIE,A.H.CHISHTI,H.W.PARKTITL PHOSPHORYLATION-INDEPENDENT DUAL-SITE BINDING OF THE FHATITL 2 DOMAIN OF KIF13 MEDIATES PHOSPHOINOSITIDE TRANSPORT VIATITL 3 CENTAURIN ALPHA1.REF PROC.NATL.ACAD.SCI.USA V. 107 20346 2010REFN ISSN 0027-8424PMID 21057110DOI 10.1073/PNAS.1009008107 Variant Set Distributions […]
General Structure Information 3obq TSG101 crystal structure of the tsg101 uev domain in complex with a human hrs psap peptide 1.4Å AUTH Y.J.IM,L.KUO,X.REN,P.V.BURGOS,X.Z.ZHAO,F.LIU,T.R.BURKE,AUTH 2 J.S.BONIFACINO,E.O.FREED,J.H.HURLEYTITL CRYSTALLOGRAPHIC AND FUNCTIONAL ANALYSIS OF THE ESCRT-ITITL 2 /HIV-1 GAG PTAP INTERACTION.REF STRUCTURE V. 18 1536 2010REFN ISSN 0969-2126PMID 21070952DOI 10.1016/J.STR.2010.08.010 Variant Set Distributions Mapped Variants
General Structure Information 2r17 VPS35 functional architecture of the retromer cargo-recognition complex 2.8Å AUTH A.HIERRO,A.L.ROJAS,R.ROJAS,N.MURTHY,G.EFFANTIN,A.V.KAJAVA,AUTH 2 A.C.STEVEN,J.S.BONIFACINO,J.H.HURLEYTITL FUNCTIONAL ARCHITECTURE OF THE RETROMER CARGO-RECOGNITIONTITL 2 COMPLEX.REF NATURE V. 449 1063 2007REFN ISSN 0028-0836PMID 17891154DOI 10.1038/NATURE06216 Variant Set Distributions Mapped Variants
General Structure Information 2h57 ARL6 crystal structure of human adp-ribosylation factor-like 6 2.0Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,J.LEW,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLATIONTITL 2 FACTOR-LIKE 6 (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4n4w SMO structure of the human smoothened receptor in complex with sant-1. 2.8Å AUTH C.WANG,H.WU,T.EVRON,E.VARDY,G.W.HAN,X.P.HUANG,S.J.HUFEISEN,AUTH 2 T.J.MANGANO,D.J.URBAN,V.KATRITCH,V.CHEREZOV,M.G.CARON,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL BASIS FOR SMOOTHENED RECEPTOR MODULATION ANDTITL 2 CHEMORESISTANCE TO ANTICANCER DRUGS.REF NAT COMMUN V. 5 4355 2014REFN ESSN 2041-1723PMID 25008467DOI 10.1038/NCOMMS5355 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4lhy RAB3IP crystal structure of gdp-bound rab8:rabin8 3.1Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 3vvw MAP1LC3C ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r2q GABARAPL1 crystal structure of human gamma-aminobutyric acid receptor- associated protein-like 1 (gabarap1), isoform cra_a 1.65Å AUTH R.PARAMANATHAN,T.DAVIS,W.TEMPEL,S.MUJIB,AUTH 2 C.BUTLER-COLE,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF HUMAN GAMMA-AMINOBUTYRIC ACIDTITL 2 RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (GABARAP1),TITL 3 ISOFORM CRA_A.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants