Assessment of Structural Intolerance and Durability
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2crf RANBP3 solution structure of the ran_bp1 domain of ran-binding protein-3 -1.0Å AUTH H.P.ZHANG,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RAN_BP1 DOMAIN OFTITL 2 RAN-BINDING PROTEIN-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gao SAR1A crystal structure of human sar1a in complex with gdp 2.0Å AUTH J.WANG,S.DIMOV,W.TEMPEL,D.YANIW,C.ARROWSMITH,AUTH 2 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN SAR1A IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r55 STARD5 human star-related lipid transfer protein 5 2.5Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 3zdq ABCB10 structure of the human mitochondrial abc transporter, abcb10 (nucleotide-free form) 2.85Å AUTH C.A.SHINTRE,A.C.W.PIKE,Q.LI,J.KIM,A.J.BARR,S.GOUBIN,AUTH 2 L.SHRESTHA,J.YANG,G.BERRIDGE,J.ROSS,P.J.STANSFELD,AUTH 3 M.S.P.SANSOM,A.M.EDWARDS,C.BOUNTRA,B.D.MARSDEN,F.VON DELFT,AUTH 4 A.N.BULLOCK,O.GILEADI,N.A.BURGESS-BROWN,E.P.CARPENTERTITL STRUCTURES OF ABCB10, A HUMAN ATP-BINDING CASSETTETITL 2 TRANSPORTER IN APO- AND NUCLEOTIDE-BOUND STATESREF PROC.NATL.ACAD.SCI.USA V. 110 9710 2013REFN ISSN 0027-8424PMID 23716676DOI 10.1073/PNAS.1217042110 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1x5e TMX1 the solution structure of the thioredoxin-like domain of human thioredoxin-related transmembrane protein -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIOREDOXIN-LIKETITL 2 DOMAIN OF HUMAN THIOREDOXIN-RELATED TRANSMEMBRANETITL 3 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lxl VTA1 lip5(mit)2 -1.0Å AUTH J.J.SKALICKY,J.ARII,D.M.WENZEL,W.M.STUBBLEFIELD,A.KATSUYAMA,AUTH 2 N.T.UTER,M.BAJOREK,D.G.MYSZKA,W.I.SUNDQUISTTITL INTERACTIONS OF THE HUMAN LIP5 REGULATORY PROTEIN WITHTITL 2 ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT.REF J.BIOL.CHEM. V. 287 43910 2012REFN ISSN 0021-9258PMID 23105106DOI 10.1074/JBC.M112.417899 Variant Set Distributions Mapped Variants
General Structure Information 2l08 UPF3A solution nmr structure of nonsense mrna reducing factor 3a from h. sapiens, northeast structural genomics consortium target hr4714b -1.0Å AUTH R.MANI,L.MAO,C.CICCOSANTI,R.SHASTRY,T.B.ACTON,R.XIAO,AUTH 2 G.V.T.SWAPNA,J.K.EVERETT,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF NONSENSE MRNA REDUCING FACTOR 3ATITL 2 FROM H. SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUMTITL 3 TARGET HR4714BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 4bx9 VPS16 human vps33a in complex with a fragment of human vps16 2.6Å AUTH S.C.GRAHAM,L.WARTOSCH,S.R.GRAY,E.J.SCOURFIELD,J.E.DEANE,AUTH 2 J.P.LUZIO,D.J.OWENTITL STRUCTURAL BASIS OF VPS33A RECRUITMENT TO THE HUMAN HOPSTITL 2 COMPLEX BY VPS16.REF PROC.NATL.ACAD.SCI.USA V. 110 13345 2013REFN ISSN 0027-8424PMID 23901104DOI 10.1073/PNAS.1307074110 Variant Set Distributions Mapped Variants
General Structure Information 4l8t MYO5C structure of the cargo binding domain from human myosin vc 2.95Å AUTH A.F.NASCIMENTO,D.M.TRINDADE,C.C.TONOLI,P.O.DE GIUSEPPE,AUTH 2 L.H.ASSIS,R.V.HONORATO,P.S.DE OLIVEIRA,P.MAHAJAN,AUTH 3 N.A.BURGESS-BROWN,F.VON DELFT,R.E.LARSON,M.T.MURAKAMITITL STRUCTURAL INSIGHTS INTO FUNCTIONAL OVERLAPPING ANDTITL 2 DIFFERENTIATION AMONG MYOSIN V MOTORS.REF J.BIOL.CHEM. V. 288 34131 2013REFN ISSN 0021-9258PMID 24097982DOI 10.1074/JBC.M113.507202 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]