Assessment of Structural Intolerance and Durability
General Structure Information 4az9 SNX24 crystal structure of phox homology domain of human sorting nexin 24 1.75Å AUTH A.E.OBERHOLZER,W.KIYANI,T.KROJER,L.SHRESTHA,F.VON DELFT,AUTH 2 D.S.FROESE,A.CHAIKUAD,J.RAYNOR,C.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,W.W.YUETITL CRYSTAL STRUCTURE OF PHOX HOMOLOGY DOMAIN OF HUMAN SORTINGTITL 2 NEXIN 24REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d2z CLIC4 crystal structure of soluble form of clic4 2.2Å AUTH Y.F.LI,D.F.LI,Z.H.ZENG,D.C.WANGTITL TRIMERIC STRUCTURE OF THE WILD SOLUBLE CHLORIDETITL 2 INTRACELLULAR ION CHANNEL CLIC4 OBSERVED INTITL 3 CRYSTALSREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 343 1272 2006REFN ISSN 0006-291XPMID 16581025DOI 10.1016/J.BBRC.2006.03.099 Variant Set Distributions Mapped Variants
General Structure Information 2mj7 AP4B1 solution nmr structure of beta-adaptin appendage domain of human adaptor protein complex 4 subunit beta, northeast structural genomics consortium (nesg) target hr8998c -1.0Å AUTH A.ELETSKY,D.J.ROTSHTEYN,K.PEDERSON,R.SHASTRY,M.MAGLAQUI,AUTH 2 H.JANJUA,R.XIAO,J.K.EVERETT,G.T.MONTELIONE,J.H.PRESTEGARD,AUTH 3 T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF BETA-ADAPTIN APPENDAGE DOMAIN OFTITL 2 HUMAN ADAPTOR PROTEIN COMPLEX 4 SUBUNIT BETA, NORTHEASTTITL 3 STRUCTURAL GENOMICS CONSORTIUM […]
General Structure Information 3ebb PLAA plap/p97 complex 1.9Å AUTH L.QIU,N.PASHKOVA,J.R.WALKER,S.WINISTORFER,A.ALLALI-HASSANI,AUTH 2 M.AKUTSU,R.PIPER,S.DHE-PAGANONTITL STRUCTURE AND FUNCTION OF THE PLAA/UFD3-P97/CDC48 COMPLEX.REF J.BIOL.CHEM. V. 285 365 2010REFN ISSN 0021-9258PMID 19887378DOI 10.1074/JBC.M109.044685 Variant Set Distributions Mapped Variants
General Structure Information 3otf HCN4 structural basis for the camp-dependent gating in human hcn4 channel 2.4Å AUTH X.XU,Z.V.VYSOTSKAYA,Q.LIU,L.ZHOUTITL STRUCTURAL BASIS FOR THE CAMP-DEPENDENT GATING IN THE HUMANTITL 2 HCN4 CHANNEL.REF J.BIOL.CHEM. V. 285 37082 2010REFN ISSN 0021-9258PMID 20829353DOI 10.1074/JBC.M110.152033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h16 ARL5A structure of human adp-ribosylation factor-like 5 (arl5) 2.0Å AUTH W.M.RABEH,W.TEMPEL,D.YANIW,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 5TITL 2 (ARL5)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4c0p TNPO3 unliganded transportin 3 2.95Å AUTH G.N.MAERTENS,N.J.COOK,W.WANG,S.HARE,S.S.GUPTA,I.OZTOP,K.LEE,AUTH 2 V.E.PYE,O.COSNEFROY,A.P.SNIJDERS,V.N.KEWALRAMANI,A.FASSATI,AUTH 3 A.ENGELMAN,P.CHEREPANOVTITL STRUCTURAL BASIS FOR NUCLEAR IMPORT OF SPLICING FACTORS BYTITL 2 HUMAN TRANSPORTIN 3.REF PROC.NATL.ACAD.SCI.USA V. 111 2728 2014REFN ISSN 0027-8424PMID 24449914DOI 10.1073/PNAS.1320755111 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bgj SNX14 crystal structure of the phox-homology domain of human sorting nexin 14 2.55Å AUTH M.VOLLMAR,W.KIYANI,L.SHRESTHA,S.GOUBIN,T.KROJER,A.C.W.PIKE,AUTH 2 E.CARPENTER,A.QUIGLEY,A.MCKENZIE,N.BURGESS-BROWN,AUTH 3 F.VON DELFT,C.H.ARROWSMITH,C.BOUNTRA,A.EDWARDS,W.W.YUETITL CRYSTAL STRUCTURE OF THE PHOX-HOMOLOGY DOMAIN OF HUMANTITL 2 SORTING NEXIN 14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4lx1 MYO5A crystal structure of myo5a globular tail domain 1.87Å AUTH O.PYLYPENKO,W.ATTANDA,C.GAUQUELIN,M.LAHMANI,D.COULIBALY,AUTH 2 B.BARON,S.HOOS,M.A.TITUS,P.ENGLAND,A.M.HOUDUSSETITL STRUCTURAL BASIS OF MYOSIN V RAB GTPASE-DEPENDENT CARGOTITL 2 RECOGNITION.REF PROC.NATL.ACAD.SCI.USA V. 110 20443 2013REFN ISSN 0027-8424PMID 24248336DOI 10.1073/PNAS.1314329110 Variant Set Distributions Mapped Variants
General Structure Information 3dyt SNX9 crystal structure of snx9px-bar (230-595), c2221 2.08Å AUTH Q.WANG,H.Y.KAAN,R.N.HOODA,S.L.GOH,H.SONDERMANNTITL STRUCTURE AND PLASTICITY OF ENDOPHILIN AND SORTINGTITL 2 NEXIN 9.REF STRUCTURE V. 16 1574 2008REFN ISSN 0969-2126PMID 18940612DOI 10.1016/J.STR.2008.07.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants