Assessment of Structural Intolerance and Durability
General Structure Information 4dpz HRASLS2 crystal structure of human hrasls2 1.25Å AUTH M.GOLCZAK,P.D.KISER,A.E.SEARS,D.T.LODOWSKI,W.S.BLANER,AUTH 2 K.PALCZEWSKITITL STRUCTURAL BASIS FOR THE ACYLTRANSFERASE ACTIVITY OFTITL 2 LECITHIN:RETINOL ACYLTRANSFERASE-LIKE PROTEINS.REF J.BIOL.CHEM. V. 287 23790 2012REFN ISSN 0021-9258PMID 22605381DOI 10.1074/JBC.M112.361550 Variant Set Distributions Mapped Variants
General Structure Information 3toa KAT8 human mof crystal structure with active site lysine partially acetylated 3.0Å AUTH H.YUAN,D.ROSSETTO,H.MELLERT,W.DANG,M.SRINIVASAN,J.JOHNSON,AUTH 2 S.HODAWADEKAR,E.C.DING,K.SPEICHER,N.ABSHIRU,R.PERRY,J.WU,AUTH 3 C.YANG,Y.G.ZHENG,D.W.SPEICHER,P.THIBAULT,A.VERREAULT,AUTH 4 F.B.JOHNSON,S.L.BERGER,R.STERNGLANZ,S.B.MCMAHON,J.COTE,AUTH 5 R.MARMORSTEINTITL MYST PROTEIN ACETYLTRANSFERASE ACTIVITY REQUIRES ACTIVE SITETITL 2 LYSINE AUTOACETYLATION.REF EMBO J. V. 31 58 2011REFN ISSN 0261-4189PMID 22020126DOI 10.1038/EMBOJ.2011.382 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4nxt MIEF1 crystal structure of the cytosolic domain of human mid51 2.12Å AUTH V.RICHTER,C.S.PALMER,L.D.OSELLAME,A.P.SINGH,K.ELGASS,AUTH 2 D.A.STROUD,H.SESAKI,M.KVANSAKUL,M.T.RYANTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF MID51, A DYNAMINTITL 2 RECEPTOR REQUIRED FOR MITOCHONDRIAL FISSION.REF J.CELL BIOL. V. 204 477 2014REFN ISSN 0021-9525PMID 24515348DOI 10.1083/JCB.201311014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2fv7 RBKS crystal structure of human ribokinase 2.1Å AUTH W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARK,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN RIBOKINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3s4y TPK1 crystal structure of human thiamin pyrophosphokinase 1 1.8Å AUTH L.SHEN,W.TEMPEL,Y.TONG,Y.LI,J.R.WALKER,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN THIAMIN PYROPHOSPHOKINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1kqo NMNAT1 crystal structure of nmn/namn adenylyltransferase complexed with deamido-nad 2.5Å AUTH T.ZHOU,O.KURNASOV,D.R.TOMCHICK,D.D.BINNS,N.V.GRISHIN,AUTH 2 V.E.MARQUEZ,A.L.OSTERMAN,H.ZHANGTITL STRUCTURE OF HHUMAN OF NICOTINAMIDE/NICOTINIC ACIDTITL 2 MONONUCLEOTIDE ADENYLYLTRANSFERASE. BASIS FOR THE DUALTITL 3 SUBSTRATE SPECIFICITY AND ACTIVATION OF THE ONCOLYTIC AGENTTITL 4 TIAZOFURIN.REF J.BIOL.CHEM. V. 277 13148 2002REFN ISSN 0021-9258PMID 11788603DOI 10.1074/JBC.M111469200 Variant Set Distributions Ripley’s […]
General Structure Information 3b7b EHMT1 euhmt1 (glp) ankyrin repeat domain (structure 1) 2.99Å AUTH R.E.COLLINS,J.P.NORTHROP,J.R.HORTON,D.Y.LEE,AUTH 2 X.ZHANG,M.R.STALLCUP,X.CHENGTITL THE ANKYRIN REPEATS OF G9A AND GLP HISTONETITL 2 METHYLTRANSFERASES ARE MONO- AND DIMETHYLLYSINETITL 3 BINDING MODULESREF NAT.STRUCT.MOL.BIOL. V. 15 245 2008REFN ISSN 1545-9993PMID 18264113DOI 10.1038/NSMB.1384 Variant Set Distributions Mapped Variants
General Structure Information 2oid IRAK4 crystal structure of irak4 kinase domain complexed with amppnp 2.3Å AUTH A.KUGLSTATTER,A.G.VILLASENOR,D.SHAW,S.W.LEE,AUTH 2 S.TSING,L.NIU,K.W.SONG,J.W.BARNETT,M.F.BROWNERTITL CUTTING EDGE: IL-1 RECEPTOR-ASSOCIATED KINASE 4TITL 2 STRUCTURES REVEAL NOVEL FEATURES AND MULTIPLETITL 3 CONFORMATIONS.REF J.IMMUNOL. V. 178 2641 2007REFN ISSN 0022-1767PMID 17312103 Variant Set Distributions Mapped Variants
General Structure Information 3f9y SETD8 structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me1 / adohcy 1.5Å AUTH J.F.COUTURE,L.M.DIRK,J.S.BRUNZELLE,R.L.HOUTZ,R.C.TRIEVELTITL STRUCTURAL ORIGINS FOR THE PRODUCT SPECIFICITY OF SET DOMAINTITL 2 PROTEIN METHYLTRANSFERASES.REF PROC.NATL.ACAD.SCI.USA V. 105 20659 2008REFN ISSN 0027-8424PMID 19088188DOI 10.1073/PNAS.0806712105 Variant Set Distributions Mapped Variants
General Structure Information 2rfi EHMT1 crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide 1.59Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant […]