Assessment of Structural Intolerance and Durability
General Structure Information 3hl2 SEPSECS the crystal structure of the human sepsecs-trnasec complex 2.81Å AUTH S.PALIOURA,R.L.SHERRER,T.A.STEITZ,D.SOLL,AUTH 2 M.SIMONOVICTITL THE HUMAN SEPSECS-TRNASEC COMPLEX REVEALS THETITL 2 MECHANISM OF SELENOCYSTEINE FORMATION.REF SCIENCE V. 325 321 2009REFN ISSN 0036-8075PMID 19608919DOI 10.1126/SCIENCE.1173755 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ijd PRDM9 crystal structure of methyltransferase domain of human pr domain- containing protein 9 2.15Å AUTH L.DOMBROVSKI,A.DONG,Y.LI,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,P.J.BROWN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PRTITL 2 DOMAIN-CONTAINING PROTEIN 9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cmw CSNK1G1 structure of human casein kinase 1 gamma-1 in complex with 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9- isopropylpurine (casp target) 1.75Å AUTH G.BUNKOCZI,P.RELLOS,S.DAS,P.SAVITSKY,F.NIESEN,F.SOBOTT,AUTH 2 O.FEDOROV,A.C.W.PIKE,F.VON DELFT,M.SUNDSTROM,C.ARROWSMITH,AUTH 3 A.EDWARDS,J.WEIGELT,S.KNAPPTITL STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITHTITL 2 2-(2-HYDROXYETHYLAMINO)-6-TITL 3 (3-CHLOROANILINO)-9-ISOPROPYLPURINE (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3ep0 PRDM12 methyltransferase domain of human pr domain-containing protein 12 2.1Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 12.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uvq UCK1 crystal structure of human uridine-cytidine kinase 1 in complex with adp 3.0Å AUTH U.KOSINSKA,P.STENMARK,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 R.COLLINS,A.EDWARDS,U.B.ERICSSON,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,L.HOLMBERG SCHIAVONE,AUTH 4 M.HOGBOM,I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,M.MOCHE,AUTH 5 M.E.P.NILSSON,T.NYMAN,D.OGG,C.PERSSON,J.SAGEMARK,AUTH 6 M.SUNDSTROM,J.UPPENBERG,M.UPPSTEN,A.G.THORSELL,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,P.NORDLUNDTITL STRUCTURE OF HUMAN URIDINE-CYTIDINE KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wvo NANS solution structure of rsgi ruh-029, an antifreeze protein like domain in human n-acetylneuraminic acid phosphate synthase gene. -1.0Å AUTH T.HAMADA,Y.ITO,T.ABE,F.HAYASHI,P.GUNTERT,M.INOUE,AUTH 2 T.KIGAWA,T.TERADA,M.SHIROUZU,M.YOSHIDA,A.TANAKA,AUTH 3 S.SUGANO,S.YOKOYAMA,H.HIROTATITL SOLUTION STRUCTURE OF THE ANTIFREEZE-LIKE DOMAINTITL 2 OF HUMAN SIALIC ACID SYNTHASEREF PROTEIN SCI. V. 15 1010 2006REFN ISSN 0961-8368PMID 16597820DOI 10.1110/PS.051700406 Variant Set Distributions Mapped […]
General Structure Information 3ope ASH1L structural basis of auto-inhibitory mechanism of histone methyltransferase 2.9Å AUTH S.AN,K.J.YEO,Y.H.JEON,J.SONGTITL CRYSTAL STRUCTURE OF THE HUMAN HISTONE METHYLTRANSFERASETITL 2 ASH1L CATALYTIC DOMAIN AND ITS IMPLICATIONS FOR THETITL 3 REGULATORY MECHANISMREF J.BIOL.CHEM. V. 286 8369 2011REFN ISSN 0021-9258PMID 21239497DOI 10.1074/JBC.M110.203380 Variant Set Distributions Mapped Variants
General Structure Information 4b6l PLK3 discovery of oral polo-like kinase (plk) inhibitors with enhanced selectivity profile using residue targeted drug design 1.9Å AUTH K.BROWN,J.D.CHARRIER,S.DURRANT,M.GRIFFITHS,C.HUDSON,D.KAY,AUTH 2 R.KNEGTEL,M.ODONNELL,F.PIERARD,H.TWIN,P.WEBER,S.YOUNGTITL DISCOVERY OF ORAL POLO-LIKE KINASE (PLK) INHIBITORS WITHTITL 2 ENHANCED SELECTIVITY PROFILE USING RESIDUE TARGETED DRUGTITL 3 DESIGNREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ihx PRDM10 methyltransferase domain of human pr domain-containing protein 10 2.5Å AUTH M.F.AMAYA,L.DOMBROVSKI,S.NI,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WU,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL METHYLTRANSFERASE DOMAIN OF HUMAN PR DOMAIN-CONTAININGTITL 2 PROTEIN 10REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c43 AASDHPPT structure of aminoadipate-semialdehyde dehydrogenase- phosphopantetheinyl transferase in complex with coenzyme a 1.93Å AUTH G.BUNKOCZI,S.PASTA,A.JOSHI,X.WU,K.L.KAVANAGH,S.SMITH,AUTH 2 U.OPPERMANNTITL MECHANISM AND SUBSTRATE RECOGNITION OF HUMAN HOLO ACPTITL 2 SYNTHASE.REF CHEM.BIOL. V. 14 1243 2007REFN ISSN 1074-5521PMID 18022563DOI 10.1016/J.CHEMBIOL.2007.10.013 Variant Set Distributions Mapped Variants