Assessment of Structural Intolerance and Durability
General Structure Information 1ll8 PASK structure and interactions of pas kinase n-terminal pas domain: model for intramolecular kinase regulation -1.0Å AUTH C.A.AMEZCUA,S.M.HARPER,J.RUTTER,K.H.GARDNERTITL STRUCTURE AND INTERACTIONS OF PAS KINASETITL 2 N-TERMINAL PAS DOMAIN: MODEL FOR INTRAMOLECULARTITL 3 KINASE REGULATION.REF STRUCTURE V. 10 1349 2002REFN ISSN 0969-2126PMID 12377121DOI 10.1016/S0969-2126(02)00857-2 Variant Set Distributions Mapped Variants
General Structure Information 3elb PCYT2 human ctp: phosphoethanolamine cytidylyltransferase in complex with cmp 2.0Å AUTH T.KARLBERG,M.WELIN,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,M.WISNIEWSKA,H.SCHULERTITL HUMAN CTP:PHOSPHOETHANOLAMINE CYTIDYLYLTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fmu SETD2 crystal structure of methyltransferase domain of human set domain- containing protein 2 compound: pr-snf 2.1Å AUTH W.ZHENG,G.IBANEZ,H.WU,G.BLUM,H.ZENG,A.DONG,F.LI,T.HAJIAN,AUTH 2 A.ALLALI-HASSANI,M.F.AMAYA,A.SIARHEYEVA,W.YU,P.J.BROWN,AUTH 3 M.SCHAPIRA,M.VEDADI,J.MIN,M.LUOTITL SINEFUNGIN DERIVATIVES AS INHIBITORS AND STRUCTURE PROBES OFTITL 2 PROTEIN LYSINE METHYLTRANSFERASE SETD2.REF J.AM.CHEM.SOC. V. 134 18004 2012REFN ISSN 0002-7863PMID 23043551DOI 10.1021/JA307060P Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2de0 FUT8 crystal structure of human alpha 1,6-fucosyltransferase, fut8 2.61Å AUTH H.IHARA,Y.IKEDA,S.TOMA,X.WANG,T.SUZUKI,J.GU,E.MIYOSHI,AUTH 2 T.TSUKIHARA,K.HONKE,A.MATSUMOTO,A.NAKAGAWA,N.TANIGUCHITITL CRYSTAL STRUCTURE OF MAMMALIANTITL 2 {ALPHA}1,6-FUCOSYLTRANSFERASE, FUT8REF GLYCOBIOLOGY V. 17 455 2007REFN ISSN 0959-6658PMID 17172260DOI 10.1093/GLYCOB/CWL079 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1udw UCK2 crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, ctp 2.6Å AUTH N.N.SUZUKI,K.KOIZUMI,M.FUKUSHIMA,A.MATSUDA,AUTH 2 F.INAGAKITITL STRUCTURAL BASIS FOR THE SPECIFICITY, CATALYSIS,TITL 2 AND REGULATION OF HUMAN URIDINE-CYTIDINE KINASEREF STRUCTURE V. 12 751 2004REFN ISSN 0969-2126PMID 15130468DOI 10.1016/J.STR.2004.02.038 Variant Set Distributions Mapped Variants
General Structure Information 4bie MAP3K5 crystal structures of ask1-inhibitor complexes 2.36Å AUTH O.SINGH,A.SHILLINGS,P.CRAGGS,I.WALL,P.ROWLAND,T.SKARZYNSKI,AUTH 2 C.I.HOBBS,P.HARDWICK,R.TANNER,M.BLUNT,D.R.WITTY,K.J.SMITHTITL CRYSTAL STRUCTURES OF ASK1-INHIBTOR COMPLEXES PROVIDE ATITL 2 PLATFORM FOR STRUCTURE BASED DRUG DESIGN.REF PROTEIN SCI. V. 22 1071 2013REFN ISSN 0961-8368PMID 23776076DOI 10.1002/PRO.2298 Variant Set Distributions Mapped Variants
General Structure Information 3bpu MAGI1 crystal structure of the 3rd pdz domain of human membrane associated guanylate kinase, c677s and c709s double mutant 1.6Å AUTH E.S.PILKA,V.HOZJAN,C.COOPER,A.C.W.PIKE,J.ELKINS,D.A.DOYLE,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF HUMAN MEMBRANETITL 2 ASSOCIATED GUANYLATE KINASE, C677S AND C709S DOUBLE MUTANT.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 3tfy NAA50 naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and coa 2.75Å AUTH G.LISZCZAK,T.ARNESEN,R.MARMORSTEINTITL STRUCTURE OF A TERNARY NAA50P (NAT5/SAN) N-TERMINALTITL 2 ACETYLTRANSFERASE COMPLEX REVEALS THE MOLECULAR BASIS FORTITL 3 SUBSTRATE-SPECIFIC ACETYLATION.REF J.BIOL.CHEM. V. 286 37002 2011REFN ISSN 0021-9258PMID 21900231DOI 10.1074/JBC.M111.282863 Variant Set Distributions Mapped Variants
General Structure Information 1zd1 SULT4A1 human sulfortransferase sult4a1 2.24Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4apc NEK1 crystal structure of human nima-related kinase 1 (nek1) 2.1Å AUTH J.M.ELKINS,T.D.M.HANCHUK,D.V.LOVATO,F.L.BASEI,G.V.MEIRELLES,AUTH 2 J.KOBARG,M.SZKLARZ,M.VOLLMAR,P.MAHAJAN,P.RELLOS,Y.ZHANG,AUTH 3 T.KROJER,A.C.W.PIKE,C.BOUNTRA,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants