1LL8.A | PASK – ASTRID

1LL8.A | PASK

General Structure Information

PDB ID	1ll8
HGNC Gene Label(s)	PASK
Structure Name	structure and interactions of pas kinase n-terminal pas domain: model for intramolecular kinase regulation
Resolution	-1.0Å
Reference	AUTH C.A.AMEZCUA,S.M.HARPER,J.RUTTER,K.H.GARDNERTITL STRUCTURE AND INTERACTIONS OF PAS KINASETITL 2 N-TERMINAL PAS DOMAIN: MODEL FOR INTRAMOLECULARTITL 3 KINASE REGULATION.REF STRUCTURE V. 10 1349 2002REFN ISSN 0969-2126PMID 12377121DOI 10.1016/S0969-2126(02)00857-2

Variant Set Distributions

ExAC Variants

Number Of Residues	107
Number Of SNVs	34
Number Of Permutations	10116
Optimal Distance Threshold	12.0
K Statistic	0.217
p-value	0.775

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:242079958	rs146901373	T>M	A:13	(6.07, 6.36, -0.02)
2:242079959	rs149007060	T>A	A:13	(6.07, 6.36, -0.02)
2:242079952		D>V	A:15	(10.17, 1.85, 5.39)
2:242079953		D>N	A:15	(10.17, 1.85, 5.39)
2:242079946		K>R	A:17	(12.43, -1.41, 9.93)
2:242079941		T>A	A:19	(5.55, -1.04, 5.97)
2:242079461		A>T	A:24	(0.53, 9.77, 1.02)
2:242079454	rs372276485	D>V	A:26	(-3.81, 14.27, -2.94)
2:242079443		G>R	A:30	(-8.53, 9.46, -1.94)
2:242079433		G>A	A:33	(-9.43, 8.40, 3.08)
2:242079403	rs373907266	K>T	A:43	(2.06, -0.81, 9.72)
2:242079401	rs200237047	L>I	A:44	(0.71, 0.58, 3.28)
2:242079397	rs370920141	T>M	A:45	(-0.81, -3.18, 5.03)
2:242079369		D>E	A:54	(-3.39, -10.30, 6.37)
2:242079368		V>M	A:55	(-1.25, -6.18, 8.48)
2:242079365	rs192087715	V>M	A:56	(0.40, -9.98, 11.69)
2:242079356		L>F	A:59	(3.93, -5.99, 7.00)
2:242079344		H>Y	A:63	(9.39, -10.84, 0.97)
2:242079341		M>V	A:64	(5.94, -14.30, -0.83)
2:242079329	COSM4092995 COSM4092994	G>S	A:68	(7.74, -18.47, -1.50)
2:242079326	rs149488988	H>Y	A:69	(5.96, -19.63, 1.94)
2:242079323	COSM1129260 COSM1129261	A>T	A:70	(0.94, -19.73, 0.87)
2:242079320		A>S	A:71	(0.61, -16.90, 4.11)
2:242079304		T>M	A:76	(-0.95, -9.51, -6.21)
2:242078209	rs369472153	V>M	A:78	(-5.33, -8.09, -3.15)
2:242078200	rs532393560	I>V	A:81	(-10.69, -3.26, 4.16)
2:242078194		R>C	A:83	(-10.51, 6.16, 7.29)
2:242078187		G>E	A:85	(-14.71, -0.09, 4.88)
2:242078178		I>S	A:88	(-13.00, -2.29, -2.88)
2:242078172	rs142624414	V>A	A:90	(-7.94, -3.02, -5.74)
2:242078160	rs565024984	M>R	A:94	(4.78, -3.16, -1.86)
2:242078148	rs143641186	R>Q	A:98	(17.90, 3.33, -2.50)
2:242078149	rs377417785 COSM3743723 COSM3743724	R>W	A:98	(17.90, 3.33, -2.50)
2:242078139		R>H	A:101	(19.74, 7.70, 3.58)
2:242078140	rs145741558	R>C	A:101	(19.74, 7.70, 3.58)
2:242078136	rs139355972	R>H	A:102	(15.58, 3.57, 4.72)
2:242078137	rs372849391	R>C	A:102	(15.58, 3.57, 4.72)
2:242078122		V>M	A:107	(1.67, 0.12, -2.45)
2:242078107		V>M	A:112	(-10.48, -4.12, -10.42)