Assessment of Structural Intolerance and Durability
General Structure Information 4aot STK10 crystal structure of human serine threonine kinase-10 (lok) bound to gw830263a 2.33Å AUTH J.M.ELKINS,E.SALAH,M.SZKLARZ,P.CANNING,F.VON DELFT,W.YUE,AUTH 2 Y.LIU,C.BOUNTRA,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 (LOK)TITL 2 BOUND TO GW830263AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fyt PRMT3 human hmt1 hnrnp methyltransferase-like 3 (s. cerevisiae) protein 2.0Å AUTH H.WU,J.R.MIN,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE 3 IN COMPLEX WITH SAH.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wwe PIK3C2G crystal structure of the phox homology domain of human phosphoinositide-3-kinase-c2-gamma 1.25Å AUTH A.K.ROOS,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTYENOVA,A.KOTZCH,P.KRAULIS,AUTH 5 N.MARKOVA,M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 6 H.SCHULER,P.SCHUTZ,M.I.SIPONEN,L.SVENSSON,AUTH 7 A.G.THORSELL,S.VAN DEN BERG,E.WAHLBERG,J.WEIGELT,AUTH 8 M.WELIN,M.WISNIEWSKA,P.NORDLUND,AUTH 9 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE PHOX HOMOLOGY DOMAIN OFTITL 2 HUMAN PHOSPHOINOSITIDE-3-KINASE-C2-GAMMAREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2buj STK16 crystal structure of the human serine-threonine kinase 16 in complex with staurosporine 2.6Å AUTH J.E.DEBRECZENI,J.ESWARAN,A.BULLOCK,P.FILIPPAKOPOULOS,AUTH 2 K.KAVANAGH,A.AMOS,O.FEDOROV,F.SOBOTT,L.J.BALL,F.VON DELFT,AUTH 3 C.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16TITL 2 IN COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2gwh SULT1C4 human sulfotranferase sult1c2 in complex with pap and pentachlorophenol 1.8Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2xrf UPP2 crystal structure of human uridine phosphorylase 2 2.3Å AUTH M.WELIN,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,S.VAN DER BERG,AUTH 6 E.WAHLBERG,J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN URIDINE PHOSPHORYLASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pfn NADK crystal structure of human nad kinase 2.7Å AUTH H.WANG,W.TEMPEL,A.K.WERNIMONT,Y.TONG,X.GUAN,Y.SHEN,Y.LI,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN NAD KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4fvp JAK2 crystal structure of the jak2 pseudokinase domain (apo form) 2.01Å AUTH R.M.BANDARANAYAKE,D.UNGUREANU,Y.SHAN,D.E.SHAW,AUTH 2 O.SILVENNOINEN,S.R.HUBBARDTITL CRYSTAL STRUCTURES OF THE JAK2 PSEUDOKINASE DOMAIN AND THETITL 2 PATHOGENIC MUTANT V617F.REF NAT.STRUCT.MOL.BIOL. V. 19 754 2012REFN ISSN 1545-9993PMID 22820988DOI 10.1038/NSMB.2348 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2a14 INMT crystal structure of human indolethylamine n- methyltransferase with sah 1.7Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN INDOLETHYLAMINETITL 2 N-METHYLTRANSFERASE IN COMPLEX WITH SAH.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3s24 RNGTT crystal structure of human mrna guanylyltransferase 3.01Å AUTH C.CHU,K.DAS,J.R.TYMINSKI,J.D.BAUMAN,R.GUAN,W.QIU,AUTH 2 G.T.MONTELIONE,E.ARNOLD,A.J.SHATKINTITL STRUCTURE OF THE GUANYLYLTRANSFERASE DOMAIN OF HUMAN MRNATITL 2 CAPPING ENZYME.REF PROC.NATL.ACAD.SCI.USA V. 108 10104 2011REFN ISSN 0027-8424PMID 21636784DOI 10.1073/PNAS.1106610108 Variant Set Distributions Mapped Variants