Assessment of Structural Intolerance and Durability
General Structure Information 2i0e PRKCB structure of catalytic domain of human protein kinase c beta ii complexed with a bisindolylmaleimide inhibitor 2.6Å AUTH N.GRODSKY,Y.LI,D.BOUZIDA,R.LOVE,J.JENSEN,B.NODES,AUTH 2 J.NONOMIYA,S.GRANTTITL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PROTEINTITL 2 KINASE C BETA II COMPLEXED WITH ATITL 3 BISINDOLYLMALEIMIDE INHIBITORREF BIOCHEMISTRY V. 45 13970 2006REFN ISSN 0006-2960PMID 17115692DOI 10.1021/BI061128H Variant […]
General Structure Information 3i6w CHEK2 structure and activation mechanism of the chk2 dna-damage checkpoint kinase 3.25Å AUTH Z.CAI,N.H.CHEHAB,N.P.PAVLETICHTITL STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA DAMAGETITL 2 CHECKPOINT KINASE.REF MOL.CELL V. 35 818 2009REFN ISSN 1097-2765PMID 19782031DOI 10.1016/J.MOLCEL.2009.09.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2q80 GGPS1 crystal structure of human geranylgeranyl pyrophosphate synthase bound to ggpp 2.7Å AUTH K.L.KAVANAGH,J.E.DUNFORD,G.BUNKOCZI,R.G.RUSSELL,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GERANYLGERANYL PYROPHOSPHATETITL 2 SYNTHASE REVEALS A NOVEL HEXAMERIC ARRANGEMENT ANDTITL 3 INHIBITORY PRODUCT BINDINGREF J.BIOL.CHEM. V. 281 22004 2006REFN ISSN 0021-9258PMID 16698791DOI 10.1074/JBC.M602603200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2vwi OXSR1 structure of the osr1 kinase, a hypertension drug target 2.15Å AUTH F.VILLA,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE OSR1 KINASE, A HYPERTENSION DRUG TARGET.REF PROTEINS V. 73 1082 2008REFN ISSN 0887-3585PMID 18831043DOI 10.1002/PROT.22238 Variant Set Distributions Mapped Variants
General Structure Information 1ggu F13A1 human factor xiii with calcium bound in the ion site 2.1Å AUTH B.A.FOX,V.C.YEE,L.C.PEDERSEN,I.LE TRONG,P.D.BISHOP,AUTH 2 R.E.STENKAMP,D.C.TELLERTITL IDENTIFICATION OF THE CALCIUM BINDING SITE AND ATITL 2 NOVEL YTTERBIUM SITE IN BLOOD COAGULATION FACTORTITL 3 XIII BY X-RAY CRYSTALLOGRAPHY.REF J.BIOL.CHEM. V. 274 4917 1999REFN ISSN 0021-9258PMID 9988734DOI 10.1074/JBC.274.8.4917 Variant Set Distributions Ripley’s […]
General Structure Information 3be1 ERBB2 dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2 2.9Å AUTH J.BOSTROM,S.F.YU,D.KAN,B.A.APPLETON,C.V.LEE,K.BILLECI,W.MAN,AUTH 2 F.PEALE,S.ROSS,C.WIESMANN,G.FUHTITL VARIANTS OF THE ANTIBODY HERCEPTIN THAT INTERACT WITH HER2TITL 2 AND VEGF AT THE ANTIGEN BINDING SITEREF SCIENCE V. 323 1610 2009REFN ISSN 0036-8075PMID 19299620DOI 10.1126/SCIENCE.1165480 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1w4r TK1 structure of a type ii thymidine kinase with bound dttp 1.83Å AUTH M.S.BIRRINGER,M.T.CLAUS,G.FOLKERS,D.P.KLOER,G.E.SCHULZ,AUTH 2 L.SCAPOZZATITL STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTPREF FEBS LETT. V. 579 1376 2005REFN ISSN 0014-5793PMID 15733844DOI 10.1016/J.FEBSLET.2005.01.034 Variant Set Distributions Mapped Variants
General Structure Information 2ax4 PAPSS2 crystal structure of the kinase domain of human 3- phosphoadenosine 5-phosphosulphate synthetase 2 2.5Å AUTH W.M.RABEH,L.NEDYALKOVA,S.ISMAIL,H.PARK,AUTH 2 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREVTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF PAPSS 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3p23 ERN1 crystal structure of the human kinase and rnase domains in complex with adp 2.7Å AUTH M.M.ALI,T.BAGRATUNI,E.L.DAVENPORT,P.R.NOWAK,AUTH 2 M.C.SILVA-SANTISTEBAN,A.HARDCASTLE,C.MCANDREWS,M.G.ROWLANDS,AUTH 3 G.J.MORGAN,W.AHERNE,I.COLLINS,F.E.DAVIES,L.H.PEARLTITL STRUCTURE OF THE IRE1 AUTOPHOSPHORYLATION COMPLEX ANDTITL 2 IMPLICATIONS FOR THE UNFOLDED PROTEIN RESPONSE.REF EMBO J. V. 30 894 2011REFN ISSN 0261-4189PMID 21317875DOI 10.1038/EMBOJ.2011.18 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3lm0 STK17B crystal structure of human serine/threonine kinase 17b (stk17b) 2.35Å Variant Set Distributions Mapped Variants