Assessment of Structural Intolerance and Durability
General Structure Information 1gbn OAT human ornithine aminotransferase complexed with the neurotoxin gabaculine 2.3Å AUTH S.A.SHAH,B.W.SHEN,A.T.BRUNGERTITL HUMAN ORNITHINE AMINOTRANSFERASE COMPLEXED WITH L-CANALINETITL 2 AND GABACULINE: STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION.REF STRUCTURE V. 5 1067 1997REFN ISSN 0969-2126PMID 9309222DOI 10.1016/S0969-2126(97)00258-X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fo0 ABL1 organization of the sh3-sh2 unit in active and inactive forms of the c-abl tyrosine kinase 2.27Å AUTH B.NAGAR,O.HANTSCHEL,M.SEELIGER,J.M.DAVIES,W.I.WEIS,AUTH 2 G.SUPERTI-FURGA,J.KURIYANTITL ORGANIZATION OF THE SH3-SH2 UNIT IN ACTIVE AND INACTIVETITL 2 FORMS OF THE C-ABL TYROSINE KINASE.REF MOL.CELL V. 21 787 2006REFN ISSN 1097-2765PMID 16543148DOI 10.1016/J.MOLCEL.2006.01.035 Variant Set Distributions Ripley’s K […]
General Structure Information 4f0i NTRK1 crystal structure of apo trka 2.3Å AUTH T.BERTRAND,M.KOTHE,J.LIU,A.DUPUY,A.RAK,P.F.BERNE,S.DAVIS,AUTH 2 T.GLADYSHEVA,C.VALTRE,J.Y.CRENNE,M.MATHIEUTITL THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONSTITL 2 FOR ACHIEVING SELECTIVE INHIBITION.REF J.MOL.BIOL. V. 423 439 2012REFN ISSN 0022-2836PMID 22902478DOI 10.1016/J.JMB.2012.08.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1c9y OTC human ornithine transcarbamylase: crystallographic insights into substrate recognition and catalytic mechanism 1.9Å AUTH D.SHI,H.MORIZONO,M.AOYAGI,M.TUCHMAN,N.M.ALLEWELLTITL CRYSTAL STRUCTURE OF HUMAN ORNITHINE TRANSCARBAMYLASETITL 2 COMPLEXED WITH CARBAMOYL PHOSPHATE AND L-NORVALINE AT 1.9 ATITL 3 RESOLUTION.REF PROTEINS V. 39 271 2000REFN ISSN 0887-3585PMID 10813810DOI 10.1002/(SICI)1097-0134(20000601)39:43.3.CO;2-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3omv RAF1 crystal structure of c-raf (raf-1) 4.0Å AUTH G.HATZIVASSILIOU,K.SONG,I.YEN,B.J.BRANDHUBER,D.J.ANDERSON,AUTH 2 R.ALVARADO,M.J.LUDLAM,D.STOKOE,S.L.GLOOR,G.VIGERS,T.MORALES,AUTH 3 I.ALIAGAS,B.LIU,S.SIDERIS,K.P.HOEFLICH,B.S.JAISWAL,AUTH 4 S.SESHAGIRI,H.KOEPPEN,M.BELVIN,L.S.FRIEDMAN,S.MALEKTITL RAF INHIBITORS PRIME WILD-TYPE RAF TO ACTIVATE THE MAPKTITL 2 PATHWAY AND ENHANCE GROWTH.REF NATURE V. 464 431 2010REFN ISSN 0028-0836PMID 20130576DOI 10.1038/NATURE08833 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v3s OXSR1 structural insights into the recognition of substrates and activators by the osr1 kinase 1.7Å AUTH F.VILLA,J.GOEBEL,F.H.RAFIQI,M.DEAK,J.THASTRUP,AUTH 2 D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURAL INSIGHTS INTO THE RECOGNITION OFTITL 2 SUBSTRATES AND ACTIVATORS BY THE OSR1 KINASEREF EMBO REP. V. 8 839 2007REFN ISSN 1469-3178PMID 17721439DOI 10.1038/SJ.EMBOR.7401048 Variant Set Distributions Mapped Variants
General Structure Information 3ggs PNP human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoro-2-deoxyadenosine 2.52Å AUTH S.AFSHAR,M.R.SAWAYA,S.L.MORRISONTITL STRUCTURE OF A MUTANT HUMAN PURINE NUCLEOSIDE PHOSPHORYLASETITL 2 WITH THE PRODRUG, 2-FLUORO-2-DEOXYADENOSINE AND THETITL 3 CYTOTOXIC DRUG, 2-FLUOROADENINE.REF PROTEIN SCI. V. 18 1107 2009REFN ISSN 0961-8368PMID 19388075DOI 10.1002/PRO.91 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ifg NTRK1 structure of the extracellular segment of human trka in complex with nerve growth factor 3.4Å AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ifg NGF structure of the extracellular segment of human trka in complex with nerve growth factor 3.4Å AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4ijq HPRT1 human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((guanine-9h-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene)) diphosphonic acid 2.0Å AUTH D.T.KEOUGH,P.SPACEK,D.HOCKOVA,T.TICHY,S.VRBKOVA,AUTH 2 L.SLAVETINSKA,Z.JANEBA,L.NAESENS,M.D.EDSTEIN,M.CHAVCHICH,AUTH 3 T.H.WANG,J.JERSEY,L.W.GUDDATTITL ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECONDTITL 2 PHOSPHONATE GROUP ARE POTENT INHIBITORS OF 6-OXOPURINETITL 3 PHOSPHORIBOSYLTRANSFERASES AND HAVE ANTIMALARIAL ACTIVITYREF J.MED.CHEM. V. 56 2513 2013REFN ISSN 0022-2623PMID 23448281DOI 10.1021/JM301893B Variant Set Distributions Pathogenic Proximity […]