General Structure Information
| PDB ID | 4fvp |
| HGNC Gene Label(s) | JAK2 |
| Structure Name | crystal structure of the jak2 pseudokinase domain (apo form) |
| Resolution | 2.01Å |
| Reference | AUTH R.M.BANDARANAYAKE,D.UNGUREANU,Y.SHAN,D.E.SHAW,AUTH 2 O.SILVENNOINEN,S.R.HUBBARDTITL CRYSTAL STRUCTURES OF THE JAK2 PSEUDOKINASE DOMAIN AND THETITL 2 PATHOGENIC MUTANT V617F.REF NAT.STRUCT.MOL.BIOL. V. 19 754 2012REFN ISSN 1545-9993PMID 22820988DOI 10.1038/NSMB.2348 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 274 |
| Number Of SNVs | 53 |
| Number Of Permutations | 27068 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.256 |
| p-value | 0.168 |
ClinVar
| Number Of Residues | 274 |
| Number Of SNVs | 3 |
| Number Of Permutations | 208 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.544 |
COSMIC
| Number Of Residues | 274 |
| Number Of SNVs | 14 |
| Number Of Permutations | 2063 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.286 |
| p-value | 0.008 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.256 |
| p-value | 0.445 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.2 |
| p-value | 0.013 |