Assessment of Structural Intolerance and Durability
General Structure Information 2WTK STRADA,CAB39,STK11 structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex 2.65Å AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 Variant Set Distributions Ripley’s K Analysis Plots
General Structure Information 3lq3 CHKB crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide 1.42Å AUTH B.S.HONG,A.ALLALI-HASSANI,W.TEMPEL,P.J.FINERTY,F.MACKENZIE,AUTH 2 S.DIMOV,M.VEDADI,H.W.PARKTITL CRYSTAL STRUCTURES OF HUMAN CHOLINE KINASE ISOFORMS INTITL 2 COMPLEX WITH HEMICHOLINIUM-3: SINGLE AMINO ACID NEAR THETITL 3 ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY.REF J.BIOL.CHEM. V. 285 16330 2010REFN ISSN 0021-9258PMID […]
General Structure Information 2bwj AK5 structure of adenylate kinase 5 2.3Å AUTH P.FILIPPAKOPOULOS,G.BUNKOCZI,A.JANSSON,E.LONGMAN,S.KNAPPTITL STRUCTURE OF ADENYLATE KINASE 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3llr DNMT3A crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha 2.3Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3a1b DNMT3A crystal structure of the dnmt3a add domain in complex with histone h3 2.29Å AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1t8u HS3ST3A1 crystal structure of human 3-o-sulfotransferase-3 with bound pap and tetrasaccharide substrate 1.95Å AUTH A.F.MOON,S.C.EDAVETTAL,J.M.KRAHN,E.M.MUNOZ,M.NEGISHI,AUTH 2 R.J.LINHARDT,J.LIU,L.C.PEDERSENTITL STRUCTURAL ANALYSIS OF THE SULFOTRANSFERASETITL 2 (3-O-SULFOTRANSFERASE ISOFORM 3) INVOLVED IN THETITL 3 BIOSYNTHESIS OF AN ENTRY RECEPTOR FOR HERPES SIMPLEX VIRUS 1REF J.BIOL.CHEM. V. 279 45185 2004REFN ISSN 0021-9258PMID 15304505DOI 10.1074/JBC.M405013200 Variant Set […]
General Structure Information 4ap6 POFUT2 crystal structure of human pofut2 e54a mutant in complex with gdp- fucose 3.401Å AUTH C.I.CHEN,J.J.KEUSCH,D.KLEIN,D.HESS,J.HOFSTEENGE,H.GUTTITL STRUCTURE OF HUMAN POFUT2: INSIGHTS INTO THROMBOSPONDINTITL 2 TYPE 1 REPEAT FOLD AND O-FUCOSYLATION.REF EMBO J. V. 31 3183 2012REFN ISSN 0261-4189PMID 22588082DOI 10.1038/EMBOJ.2012.143 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2izs CSNK1G3 structure of casein kinase gamma 3 in complex with inhibitor 1.95Å AUTH G.BUNKOCZI,E.SALAH,P.RELLOS,S.DAS,O.FEDOROV,P.SAVITSKY,AUTH 2 J.E.DEBRECZENI,O.GILEADI,M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,AUTH 3 J.WEIGELT,F.VON DELFT,S.KNAPPTITL INHIBITOR BINDING BY CASEIN KINASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4l7r PARP3 human artd3 (parp3) – catalytic domain in complex with inhibitor me0400 2.2Å AUTH A.E.LINDGREN,T.KARLBERG,T.EKBLAD,S.SPJUT,A.G.THORSELL,AUTH 2 C.D.ANDERSSON,T.T.NHAN,V.HELLSTEN,J.WEIGELT,A.LINUSSON,AUTH 3 H.SCHULER,M.ELOFSSONTITL CHEMICAL PROBES TO STUDY ADP-RIBOSYLATION: SYNTHESIS ANDTITL 2 BIOCHEMICAL EVALUATION OF INHIBITORS OF THE HUMANTITL 3 ADP-RIBOSYLTRANSFERASE ARTD3/PARP3.REF J.MED.CHEM. V. 56 9556 2013REFN ISSN 0022-2623PMID 24188023DOI 10.1021/JM401394U Variant Set Distributions Ripley’s K […]
General Structure Information 3rpn GSTK1 crystal structure of human kappa class glutathione transferase in complex with s-hexylglutathione 1.9Å AUTH B.WANG,Y.PENG,T.ZHANG,J.DINGTITL CRYSTAL STRUCTURES AND KINETIC STUDIES OF HUMAN KAPPA CLASSTITL 2 GLUTATHIONE TRANSFERASE PROVIDE INSIGHTS INTO THE CATALYTICTITL 3 MECHANISM.REF BIOCHEM.J. V. 439 215 2011REFN ISSN 0264-6021PMID 21728995DOI 10.1042/BJ20110753 Variant Set Distributions Ripley’s K Analysis Plots […]