General Structure Information
| PDB ID | 4l7r |
| HGNC Gene Label(s) | PARP3 |
| Structure Name | human artd3 (parp3) – catalytic domain in complex with inhibitor me0400 |
| Resolution | 2.2Å |
| Reference | AUTH A.E.LINDGREN,T.KARLBERG,T.EKBLAD,S.SPJUT,A.G.THORSELL,AUTH 2 C.D.ANDERSSON,T.T.NHAN,V.HELLSTEN,J.WEIGELT,A.LINUSSON,AUTH 3 H.SCHULER,M.ELOFSSONTITL CHEMICAL PROBES TO STUDY ADP-RIBOSYLATION: SYNTHESIS ANDTITL 2 BIOCHEMICAL EVALUATION OF INHIBITORS OF THE HUMANTITL 3 ADP-RIBOSYLTRANSFERASE ARTD3/PARP3.REF J.MED.CHEM. V. 56 9556 2013REFN ISSN 0022-2623PMID 24188023DOI 10.1021/JM401394U |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 352 |
| Number Of SNVs | 103 |
| Number Of Permutations | 18230 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.134 |
| p-value | 0.784 |
COSMIC
| Number Of Residues | 352 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1370 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.2 |
| p-value | 0.146 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 103 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.171 |
| p-value | 0.241 |