Assessment of Structural Intolerance and Durability
General Structure Information 1svc NFKB1 nfkb p50 homodimer bound to dna 2.6Å AUTH C.W.MULLER,F.A.REY,M.SODEOKA,G.L.VERDINE,AUTH 2 S.C.HARRISONTITL STRUCTURE OF THE NF-KAPPA B P50 HOMODIMER BOUND TOTITL 2 DNA.REF NATURE V. 373 311 1995REFN ISSN 0028-0836PMID 7830764DOI 10.1038/373311A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2prt WT1 structure of the wilms tumor suppressor protein zinc finger domain bound to dna 3.15Å AUTH R.STOLL,B.M.LEE,E.W.DEBLER,J.H.LAITY,I.A.WILSON,AUTH 2 H.J.DYSON,P.E.WRIGHTTITL STRUCTURE OF THE WILMS TUMOR SUPPRESSOR PROTEINTITL 2 ZINC FINGER DOMAIN BOUND TO DNAREF J.MOL.BIOL. V. 372 1227 2007REFN ISSN 0022-2836PMID 17716689DOI 10.1016/J.JMB.2007.07.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1c9b TBP crystal structure of a human tbp core domain-human tfiib core domain complex bound to an extended, modified adenoviral major late promoter (admlp) 2.65Å AUTH F.T.TSAI,P.B.SIGLERTITL STRUCTURAL BASIS OF PREINITIATION COMPLEX ASSEMBLYTITL 2 ON HUMAN POL II PROMOTERS.REF EMBO J. V. 19 25 2000REFN ISSN 0261-4189PMID 10619841DOI 10.1093/EMBOJ/19.1.25 Variant Set Distributions […]
General Structure Information 1ga5 NR1D1 crystal structure of the orphan nuclear receptor rev- erb(alpha) dna-binding domain bound to its cognate response element 2.4Å AUTH M.L.SIERK,Q.ZHAO,F.RASTINEJADTITL DNA DEFORMABILITY AS A RECOGNITION FEATURE IN THETITL 2 REVERB RESPONSE ELEMENTREF BIOCHEMISTRY V. 40 12833 2001REFN ISSN 0006-2960PMID 11669620DOI 10.1021/BI011086R Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2nll THRB retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna 1.9Å AUTH F.RASTINEJAD,T.PERLMANN,R.M.EVANS,P.B.SIGLERTITL STRUCTURAL DETERMINANTS OF NUCLEAR RECEPTORTITL 2 ASSEMBLY ON DNA DIRECT REPEATS.REF NATURE V. 375 203 1995REFN ISSN 0028-0836PMID 7746322DOI 10.1038/375203A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1kb4 VDR crystal structure of vdr dna-binding domain bound to a canonical direct repeat with three base pair spacer (dr3) response element 2.8Å AUTH P.L.SHAFFER,D.T.GEWIRTHTITL STRUCTURAL BASIS OF VDR-DNA INTERACTIONS ON DIRECTTITL 2 REPEAT RESPONSE ELEMENTS.REF EMBO J. V. 21 2242 2002REFN ISSN 0261-4189PMID 11980721DOI 10.1093/EMBOJ/21.9.2242 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 1dsz RARA structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1 1.7Å AUTH F.RASTINEJAD,T.WAGNER,Q.ZHAO,S.KHORASANIZADEHTITL STRUCTURE OF THE RXR-RAR DNA-BINDING COMPLEX ONTITL 2 THE RETINOIC ACID RESPONSE ELEMENT DR1.REF EMBO J. V. 19 1045 2000REFN ISSN 0261-4189PMID 10698945DOI 10.1093/EMBOJ/19.5.1045 Variant Set Distributions Mapped Variants
General Structure Information 2gli GLI1 five-finger gli/dna complex 2.6Å AUTH N.P.PAVLETICH,C.O.PABOTITL CRYSTAL STRUCTURE OF A FIVE-FINGER GLI-DNATITL 2 COMPLEX: NEW PERSPECTIVES ON ZINC FINGERS.REF SCIENCE V. 261 1701 1993REFN ISSN 0036-8075PMID 8378770 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1hcq ESR1 the crystal structure of the estrogen receptor dna-binding domain bound to dna: how receptors discriminate between their response elements 2.4Å AUTH J.W.SCHWABE,L.CHAPMAN,J.T.FINCH,D.RHODESTITL THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTORTITL 2 DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORSTITL 3 DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS.REF CELL(CAMBRIDGE,MASS.) V. 75 567 1993REFN ISSN 0092-8674PMID […]
General Structure Information 1fos JUN two human c-fos:c-jun:dna complexes 3.05Å AUTH J.N.GLOVER,S.C.HARRISONTITL CRYSTAL STRUCTURE OF THE HETERODIMERIC BZIPTITL 2 TRANSCRIPTION FACTOR C-FOS-C-JUN BOUND TO DNA.REF NATURE V. 373 257 1995REFN ISSN 0028-0836PMID 7816143DOI 10.1038/373257A0 Variant Set Distributions Mapped Variants