Assessment of Structural Intolerance and Durability
General Structure Information 1fos FOS two human c-fos:c-jun:dna complexes 3.05Å AUTH J.N.GLOVER,S.C.HARRISONTITL CRYSTAL STRUCTURE OF THE HETERODIMERIC BZIPTITL 2 TRANSCRIPTION FACTOR C-FOS-C-JUN BOUND TO DNA.REF NATURE V. 373 257 1995REFN ISSN 0028-0836PMID 7816143DOI 10.1038/373257A0 Variant Set Distributions Mapped Variants
General Structure Information 1nkp MYC crystal structure of myc-max recognizing dna 1.8Å AUTH S.K.NAIR,S.K.BURLEYTITL X-RAY STRUCTURES OF MYC-MAX AND MAD-MAXTITL 2 RECOGNIZING DNA: MOLECULAR BASES OF REGULATION BYTITL 3 PROTO-ONCOGENIC TRANSCRIPTION FACTORSREF CELL(CAMBRIDGE,MASS.) V. 112 193 2003REFN ISSN 0092-8674PMID 12553908DOI 10.1016/S0092-8674(02)01284-9 Variant Set Distributions Mapped Variants
General Structure Information 1yo5 SPDEF analysis of the 2.0a crystal structure of the protein-dna complex of human pdef ets domain bound to the prostate specific antigen regulatory site 2.0Å AUTH Y.WANG,L.FENG,M.SAID,S.BALDERMAN,Z.FAYAZI,Y.LIU,AUTH 2 D.GHOSH,A.M.GULICKTITL ANALYSIS OF THE 2.0 A CRYSTAL STRUCTURE OF THETITL 2 PROTEIN-DNA COMPLEX OF THE HUMAN PDEF ETS DOMAINTITL 3 BOUND TO THE […]
General Structure Information 1imh NFAT5 tonebp/dna complex 2.86Å AUTH J.C.STROUD,C.LOPEZ-RODRIGUEZ,A.RAO,L.CHENTITL STRUCTURE OF A TONEBP-DNA COMPLEX REVEALS DNATITL 2 ENCIRCLED BY A TRANSCRIPTION FACTOR.REF NAT.STRUCT.BIOL. V. 9 90 2002REFN ISSN 1072-8368PMID 11780147DOI 10.1038/NSB749 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2a66 NR5A2 human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter 2.2Å AUTH I.H.SOLOMON,J.M.HAGER,R.SAFI,D.P.MCDONNELL,AUTH 2 M.R.REDINBO,E.A.ORTLUNDTITL CRYSTAL STRUCTURE OF THE HUMAN LRH-1 DBD-DNATITL 2 COMPLEX REVEALS FTZ-F1 DOMAIN POSITIONING ISTITL 3 REQUIRED FOR RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 354 1091 2005REFN ISSN 0022-2836PMID 16289203DOI 10.1016/J.JMB.2005.10.009 Variant […]
General Structure Information 2as5 FOXP2 structure of the dna binding domains of nfat and foxp2 bound specifically to dna. 2.7Å AUTH Y.WU,M.BORDE,V.HEISSMEYER,M.FEUERER,A.D.LAPAN,AUTH 2 J.C.STROUD,D.L.BATES,L.GUO,A.HAN,S.F.ZIEGLER,AUTH 3 D.MATHIS,C.BENOIST,L.CHEN,A.RAOTITL FOXP3 CONTROLS REGULATORY T CELL FUNCTION THROUGHTITL 2 COOPERATION WITH NFAT.REF CELL(CAMBRIDGE,MASS.) V. 126 375 2006REFN ISSN 0092-8674PMID 16873067DOI 10.1016/J.CELL.2006.05.042 Variant Set Distributions Mapped Variants