Assessment of Structural Intolerance and Durability
General Structure Information 2jp2 SPRED2 solution structure and resonance assignment of the n- terminal evh1 domain from the human spred2 protein (sprouty-related protein with evh1 domain isoform 2) -1.0Å AUTH J.ZIMMERMANN,T.JARCHAU,U.WALTER,H.OSCHKINAT,AUTH 2 L.J.BALLTITL 1H, 13C AND 15N RESONANCE ASSIGNMENT OF THE HUMANTITL 2 SPRED2 EVH1 DOMAINREF J.BIOMOL.NMR V. 29 435 2004REFN ISSN 0925-2738PMID 15213456DOI 10.1023/B:JNMR.0000032526.17586.8C […]
General Structure Information 1ueq MAGI2 solution structure of the first pdz domain of human atrophin-1 interacting protein 1 (kiaa0705 protein) -1.0Å AUTH C.ZHAO,T.KIGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST PDZ DOMAIN OFTITL 2 HUMAN ATROPHIN-1 INTERACTING PROTEIN 1 (KIAA0705TITL 3 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3b76 LNX1 crystal structure of the third pdz domain of human ligand-of-numb protein-x (lnx1) in complex with the c-terminal peptide from the coxsackievirus and adenovirus receptor 1.75Å AUTH E.UGOCHUKWU,N.BURGESS-BROWN,G.BERRIDGE,J.ELKINS,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,M.SUNDSTROM,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,AUTH 3 O.GILEADI,F.VON DELFT,D.DOYLETITL CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN OF HUMANTITL 2 LIGAND-OF-NUMB PROTEIN-X (LNX1) IN COMPLEX WITH THETITL 3 […]
General Structure Information 3smt SETD3 crystal structure of human set domain-containing protein3 2.04Å AUTH H.ZENG,A.DONG,J.R.WALKER,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF HUMAN SET DOMAIN-CONTAINING PROTEIN3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4hwn FCRLA crystal structure of the second ig-c2 domain of human fc-receptor like a (fcrla), isoform 9 [nysgrc-005836] 2.01Å AUTH P.R.KUMAR,S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE SECOND IG-C2 DOMAIN OF THE HUMANTITL 2 FC-RECEPTOR LIKE A, ISOFORM 9 [NYSGRC-005836]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4dxr SYNE1 human sun2-kash1 complex 2.32Å AUTH B.A.SOSA,A.ROTHBALLER,U.KUTAY,T.U.SCHWARTZTITL LINC COMPLEXES FORM BY BINDING OF THREE KASH PEPTIDES TOTITL 2 DOMAIN INTERFACES OF TRIMERIC SUN PROTEINS.REF CELL(CAMBRIDGE,MASS.) V. 149 1035 2012REFN ISSN 0092-8674PMID 22632968DOI 10.1016/J.CELL.2012.03.046 Variant Set Distributions Mapped Variants
General Structure Information 3ihj GPT2 human alanine aminotransferase 2 in complex with plp 2.3Å AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,A.KOTZSCH,M.MOCHE,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,H.SCHULERTITL HUMAN GLUTAMATE PYRUVATE TRANSAMINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wxt EPS8L3 solution structure of the sh3 domain of human hypothetical protein flj21522 -1.0Å AUTH M.YONEYAMA,K.SAITO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 HYPOTHETICAL PROTEIN FLJ21522REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3s93 TDRD5 crystal structure of conserved motif in tdrd5 2.28Å AUTH X.CHAO,W.TEMPEL,C.BIAN,J.KANIA,A.K.WERNIMONT,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MINTITL CRYSTAL STRUCTURE OF CONSERVED MOTIF IN TDRD5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3l11 RNF168 crystal structure of the ring domain of rnf168 2.12Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants