Assessment of Structural Intolerance and Durability
General Structure Information 1×62 PDLIM1 solution structure of the lim domain of carboxyl terminal lim domain protein 1 -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE LIM DOMAIN OF CARBOXYLTITL 2 TERMINAL LIM DOMAIN PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gry KIF2A crystal structure of the human kif2 motor domain in complex with adp 2.35Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN KIF2 MOTOR DOMAIN IN COMPLEXTITL 2 WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kup FRS3 solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk -1.0Å AUTH S.KOSHIBA,H.LI,Y.MOTODA,T.TOMIZAWA,T.KASAI,N.TOCHIO,AUTH 2 T.YABUKI,T.HARADA,S.WATANABE,A.TANAKA,M.SHIROUZU,T.KIGAWA,AUTH 3 T.YAMAMOTO,S.YOKOYAMATITL STRUCTURAL BASIS FOR THE RECOGNITION OFTITL 2 NUCLEOPHOSMIN-ANAPLASTIC LYMPHOMA KINASE ONCOPROTEIN BY THETITL 3 PHOSPHOTYROSINE BINDING DOMAIN OF SUC1-ASSOCIATEDTITL 4 NEUROTROPHIC FACTOR-INDUCED TYROSINE-PHOSPHORYLATED TARGET-2REF […]
General Structure Information 2jnu RGS14 solution structure of the rgs domain of human rgs14 -1.0Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,AUTH 2 A.P.TURNBULL,L.J.BALL,G.A.SCHOCH,C.GILEADI,AUTH 3 O.Y.FEDOROV,E.F.DOWLER,V.A.HIGMAN,S.Q.HUTSELL,AUTH 4 M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITSTITL 2 INTERACTION WITH HETEROTRIMERIC G PROTEINTITL 3 ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 3pfw GAPDHS crystal structure of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (gapds) complex with nad, a binary form 2.15Å AUTH A.CHAIKUAD,N.SHAFQAT,R.AL-MOKHTAR,G.CAMERON,A.R.CLARKE,AUTH 2 R.L.BRADY,U.OPPERMANN,J.FRAYNE,W.W.YUETITL STRUCTURE AND KINETIC CHARACTERIZATION OF HUMANTITL 2 SPERM-SPECIFIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE,TITL 3 GAPDS.REF BIOCHEM.J. V. 435 401 2011REFN ISSN 0264-6021PMID 21269272DOI 10.1042/BJ20101442 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2e70 SUPT5H solution structure of the fifth kow motif of human transcription elongation factor spt5 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH KOW MOTIF OF HUMANTITL 2 TRANSCRIPTION ELONGATION FACTOR SPT5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qq2 ACOT7 crystal structure of c-terminal domain of human acyl-coa thioesterase 7 2.8Å AUTH R.BUSAM,L.LEHTIO,C.H.ARROWSMITH,H.BERGLUND,R.COLLINS,AUTH 2 L.G.DAHLGREN,M.D.HERMAN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRESLUND,M.HAMMARSTROM,B.M.HALLBERG,L.HOLMBERG-SCHIAVONE,AUTH 4 I.JOHANSSON,A.KALLAS,T.KARLBERG,T.KOTENYOVA,M.MOCHE,AUTH 5 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 C.PERSSONTITL HUMAN ACYL-COA THIOESTERASE 7.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4e6r NCK2 crystal structure of a cytoplasmic protein nck2 (nck2) from homo sapiens at 2.20 a resolution 2.2Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A CYTOPLASMIC PROTEIN NCK2 (NCK2) FROMTITL 2 HOMO SAPIENS AT 2.20 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2mk2 INPPL1 solution nmr structure of n-terminal domain (sh2 domain) of human inositol polyphosphate phosphatase-like protein 1 (inppl1) (fragment 20-117), northeast structural genomics consortium target hr9134a -1.0Å AUTH Y.YANG,T.A.RAMELOT,H.JANJUA,R.XIAO,J.K.EVERETT,AUTH 2 G.T.MONTELIONE,M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF N-TERMINAL DOMAIN (SH2 DOMAIN) OFTITL 2 HUMAN INOSITOL POLYPHOSPHATE PHOSPHATASE-LIKE PROTEIN 1TITL 3 (INPPL1) (FRAGMENT 20-117), NORTHEAST […]
General Structure Information 2dyl MAP2K7 crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (s287d, t291d) 2.45Å AUTH M.KUKIMOTO-NIINO,T.TAKAGI,T.KAMINISHI,AUTH 2 T.UCHIKUBO-KAMO,T.TERADA,O.MATSUZAKI,M.SHIROUZU,AUTH 3 S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATEDTITL 2 PROTEIN KINASE KINASE 7 ACTIVATED MUTANT (S287D,TITL 3 T291D)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]