Assessment of Structural Intolerance and Durability
General Structure Information 4jxm RRP9 crystal structure of rrp9 wd40 repeats 1.92Å AUTH X.WU,W.TEMPEL,C.XU,M.EL BAKKOURI,H.HE,Y.LI,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF RRP9 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lm0 STK17B crystal structure of human serine/threonine kinase 17b (stk17b) 2.35Å Variant Set Distributions Mapped Variants
General Structure Information 2qg1 MPDZ crystal structure of the 11th pdz domain of mpdz (mupp1) 1.4Å AUTH E.PAPAGRIGORIOU,E.SALAH,C.PHILLIPS,P.SAVITSKY,AUTH 2 P.BOISGUERIN,H.OSCHKINAT,C.GILEADI,X.YANG,AUTH 3 J.M.ELKINS,E.UGOCHUKWU,G.BUNKOCZI,J.UPPENBERG,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF THE 11TH PDZ DOMAIN OF MPDZTITL 2 (MUPP1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fo9 PIAS2 crystal structure of the e3 sumo ligase pias2 2.39Å AUTH J.HU,A.DONG,E.DOBROVETSKY,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE E3 SUMO LIGASE PIAS2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3l50 GMFG the crystal structure of human glia maturation factor, gamma (gmfg) 1.9Å AUTH E.UGOCHUKWU,E.PILKA,E.KRYSZTOFINSKA,E.HAPKA,T.KROJER,AUTH 2 J.MUNIZ,M.VOLLMAR,A.C.W.PIKE,F.VON DELFT,K.L.KAVANAGH,AUTH 3 U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GLIA MATURATION FACTOR, GAMMATITL 2 (GMFG)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fyt PRMT3 human hmt1 hnrnp methyltransferase-like 3 (s. cerevisiae) protein 2.0Å AUTH H.WU,J.R.MIN,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE 3 IN COMPLEX WITH SAH.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lg7 MBD4 crystal structure mbd4 mbd domain in complex with methylated cpg dna 2.5Å AUTH C.XU,W.TEMPEL,A.K.WERNIMONT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MINTITL CRYSTAL STRUCTURE MBD4 MBD DOMAIN IN COMPLEX WITH METHYLATEDTITL 2 CPG DNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2opg MPDZ the crystal structure of the 10th pdz domain of mpdz 1.5Å AUTH C.GILEADI,C.PHILLIPS,J.ELKINS,E.PAPAGRIGORIOU,AUTH 2 E.UGOCHUKWU,F.GORREC,P.SAVITSKY,C.UMEANO,AUTH 3 G.BERRIDGE,O.GILEADI,E.SALAH,A.EDWARDS,AUTH 4 C.H.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.A.DOYLE,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF THE 10TH PDZ DOMAIN OFTITL 2 MPDZREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gwh SULT1C4 human sulfotranferase sult1c2 in complex with pap and pentachlorophenol 1.8Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2iwq MPDZ 7th pdz domain of multiple pdz domain protein mpdz 1.8Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSIONS.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants