Assessment of Structural Intolerance and Durability
General Structure Information 2qw4 NR4A1 human nr4a1 ligand-binding domain 2.8Å AUTH J.R.MIN,A.SCHUETZ,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN NR4A1 LIGAND-BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bic MUT crystal structure of human methylmalonyl-coa mutase 2.6Å AUTH D.S.FROESE,G.KOCHAN,J.R.MUNIZ,X.WU,C.GILEADI,E.UGOCHUKWU,AUTH 2 E.KRYSZTOFINSKA,R.A.GRAVEL,U.OPPERMANN,W.W.YUETITL STRUCTURES OF THE HUMAN GTPASE MMAA AND VITAMINTITL 2 B12-DEPENDENT METHYLMALONYL-COA MUTASE AND INSIGHT INTOTITL 3 THEIR COMPLEX FORMATION.REF J.BIOL.CHEM. V. 285 38204 2010REFN ISSN 0021-9258PMID 20876572DOI 10.1074/JBC.M110.177717 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3kka EPHA1 co-crystal structure of the sam domains of epha1 and epha2 2.4Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL CO-CRYSTAL STRUCTURE OF THE SAM DOMAINS OF HUMANTITL 2 EPHRIN TYPE-A RECEPTOR 1 AND HUMAN EPHRIN TYPE-ATITL 3 RECEPTOR 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2b49 PTPN3 crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3 1.54Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3op3 CDC25C crystal structure of cell division cycle 25c protein isoform a from homo sapiens 2.63Å AUTH Y.KIM,A.WEGER,C.HATZOS,P.SAVITSKY,C.JOHANSSON,L.BALL,A.BARR,AUTH 2 M.VOLLMAR,J.MUNIZ,J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,O.GILEADI,F.VON DELFT,S.KNAPP,A.JOACHIMIAKTITL CRYSTAL STRUCTURE OF CELL DIVISION CYCLE 25C PROTEIN ISOFORMTITL 2 A FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qon EPHA3 human epha3 kinase and juxtamembrane region, y596f:y602f:y742a triple mutant 1.79Å AUTH T.L.DAVIS,J.R.WALKER,P.LOPPNAU,C.BUTLER-COLE,AUTH 2 A.ALLALI-HASSANI,S.DHE-PAGANONTITL AUTOREGULATION BY THE JUXTAMEMBRANE REGION OF THE HUMANTITL 2 EPHRIN RECEPTOR TYROSINE KINASE A3 (EPHA3).REF STRUCTURE V. 16 873 2008REFN ISSN 0969-2126PMID 18547520DOI 10.1016/J.STR.2008.03.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2hw5 ECHS1 the crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1 2.55Å AUTH A.P.TURNBULL,E.SALAH,F.NIESEN,J.DEBRECZENI,E.UGOCHUKWU,AUTH 2 A.C.W.PIKE,K.KAVANAGH,O.GILEADI,F.GORREC,C.UMEANO,AUTH 3 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 4 U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN ENOYL-COENZYME A (COA)TITL 2 HYDRATASE SHORT CHAIN 1, ECHS1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3qk3 CRYBB3 crystal structure of human beta-crystallin b3 1.95Å Variant Set Distributions Mapped Variants
General Structure Information 3sn5 CYP7A1 crystal structure of human cyp7a1 in complex with cholest-4-en-3-one 2.75Å AUTH N.STRUSHKEVICH,W.TEMPEL,F.MACKENZIE,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN CYP7A1 IN COMPLEX WITHTITL 2 CHOLEST-4-EN-3-ONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ar7 AK4 crystal structure of human adenylate kinase 4, ak4 2.15Å AUTH P.FILIPPAKOPOULOS,A.P.TURNBULL,O.FEDOROV,J.WEIGELT,AUTH 2 G.BUNKOCZI,E.UGOCHUKWU,J.DEBRECZENI,F.NIESEN,F.VON DELFT,AUTH 3 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN ADENYLATE KINASE 4, AK4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants