General Structure Information
| PDB ID | 2qon |
| HGNC Gene Label(s) | EPHA3 |
| Structure Name | human epha3 kinase and juxtamembrane region, y596f:y602f:y742a triple mutant |
| Resolution | 1.79Å |
| Reference | AUTH T.L.DAVIS,J.R.WALKER,P.LOPPNAU,C.BUTLER-COLE,AUTH 2 A.ALLALI-HASSANI,S.DHE-PAGANONTITL AUTOREGULATION BY THE JUXTAMEMBRANE REGION OF THE HUMANTITL 2 EPHRIN RECEPTOR TYROSINE KINASE A3 (EPHA3).REF STRUCTURE V. 16 873 2008REFN ISSN 0969-2126PMID 18547520DOI 10.1016/J.STR.2008.03.008 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 281 |
| Number Of SNVs | 59 |
| Number Of Permutations | 29035 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.019 |
| p-value | 0.892 |
COSMIC
| Number Of Residues | 281 |
| Number Of SNVs | 14 |
| Number Of Permutations | 7662 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.451 |
| p-value | 0.583 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.109 |
| p-value | 0.528 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
