Assessment of Structural Intolerance and Durability
General Structure Information 3iar ADA the crystal structure of human adenosine deaminase 1.52Å AUTH E.UGOCHUKWU,Y.ZHANG,E.HAPKA,W.W.YUE,J.E.BRAY,J.MUNIZ,AUTH 2 N.BURGESS-BROWN,A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN ADENOSINE DEAMINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3lyi BRD1 pwwp domain of human bromodomain-containing protein 1 2.1Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3con NRAS crystal structure of the human nras gtpase bound with gdp 1.65Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUNDTITL 2 WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2q80 GGPS1 crystal structure of human geranylgeranyl pyrophosphate synthase bound to ggpp 2.7Å AUTH K.L.KAVANAGH,J.E.DUNFORD,G.BUNKOCZI,R.G.RUSSELL,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GERANYLGERANYL PYROPHOSPHATETITL 2 SYNTHASE REVEALS A NOVEL HEXAMERIC ARRANGEMENT ANDTITL 3 INHIBITORY PRODUCT BINDINGREF J.BIOL.CHEM. V. 281 22004 2006REFN ISSN 0021-9258PMID 16698791DOI 10.1074/JBC.M602603200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2gf9 RAB3D crystal structure of human rab3d in complex with gdp 1.53Å AUTH B.HONG,J.WANG,L.SHEN,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB3D IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kci HERC2 the third rld domain of herc2 1.8Å AUTH J.R.WALKER,L.QIU,A.VESTERBERG,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE THIRD RLD DOMAIN OF HERC2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ax4 PAPSS2 crystal structure of the kinase domain of human 3- phosphoadenosine 5-phosphosulphate synthetase 2 2.5Å AUTH W.M.RABEH,L.NEDYALKOVA,S.ISMAIL,H.PARK,AUTH 2 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREVTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF PAPSS 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2q3e UGDH structure of human udp-glucose dehydrogenase complexed with nadh and udp-glucose 2.0Å AUTH S.EGGER,A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANN,B.NIDETZKYTITL STRUCTURE AND MECHANISM OF HUMAN UDP-GLUCOSETITL 2 6-DEHYDROGENASE.REF J.BIOL.CHEM. V. 286 23877 2011REFN ISSN 0021-9258PMID 21502315DOI 10.1074/JBC.M111.234682 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2iwn MPDZ 3rd pdz domain of multiple pdz domain protein mpdz (casp target) 1.35Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,AUTH 2 C.PHILLIPS,C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINEDTITL 2 WITH THE HELP OF SELF-BINDING C-TERMINALTITL 3 EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 2iwp MPDZ 12th pdz domain of multiple pdz domain protein mpdz (casp target) 2.15Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants