Assessment of Structural Intolerance and Durability
General Structure Information 2crw ARFGAP3 solution structure of the arfgap domain of adp-ribosylation factor gtpaseactivating protein 3 (arfgap 3) -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ARFGAP DOMAIN OFTITL 2 ADP-RIBOSYLATION FACTOR GTPASEACTIVATING PROTEIN 3TITL 3 (ARFGAP 3)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3dzx TBC1D22B crystal structure of the rabgap domain of human tbc1d22b 2.3Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,Y.SHEN,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF HUMAN TBC1D22BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dlv RGS18 solution structure of the rgs domain of human regulator of g-protein signaling 18 -1.0Å AUTH H.P.ZHANG,T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RGS DOMAIN OF HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 18REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cmw CSNK1G1 structure of human casein kinase 1 gamma-1 in complex with 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9- isopropylpurine (casp target) 1.75Å AUTH G.BUNKOCZI,P.RELLOS,S.DAS,P.SAVITSKY,F.NIESEN,F.SOBOTT,AUTH 2 O.FEDOROV,A.C.W.PIKE,F.VON DELFT,M.SUNDSTROM,C.ARROWSMITH,AUTH 3 A.EDWARDS,J.WEIGELT,S.KNAPPTITL STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITHTITL 2 2-(2-HYDROXYETHYLAMINO)-6-TITL 3 (3-CHLOROANILINO)-9-ISOPROPYLPURINE (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3bc1 SYTL2 crystal structure of the complex rab27a-slp2a 1.8Å AUTH L.M.G.CHAVAS,K.IHARA,M.KAWASAKI,S.TORII,T.UEJIMA,R.KATO,AUTH 2 T.IZUMI,S.WAKATSUKITITL ELUCIDATION OF RAB27 RECRUITMENT BY ITS EFFECTORS: STRUCTURETITL 2 OF RAB27A BOUND TO EXOPHILIN4/SLP2-AREF STRUCTURE V. 16 1468 2008REFN ISSN 0969-2126PMID 18940603DOI 10.1016/J.STR.2008.07.015 Variant Set Distributions Mapped Variants
General Structure Information 2pz1 ARHGEF4 crystal structure of auto-inhibited asef 2.25Å AUTH N.MITIN,L.BETTS,M.E.YOHE,C.J.DER,J.SONDEK,K.L.ROSSMANTITL RELEASE OF AUTOINHIBITION OF ASEF BY APC LEADS TO CDC42TITL 2 ACTIVATION AND TUMOR SUPPRESSION.REF NAT.STRUCT.MOL.BIOL. V. 14 814 2007REFN ISSN 1545-9993PMID 17704816DOI 10.1038/NSMB1290 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4jiz MOB1A human mob1-phosphopeptide complex 2.1Å AUTH J.M.ROCK,D.LIM,L.STACH,R.W.OGRODOWICZ,J.M.KECK,M.H.JONES,AUTH 2 C.C.WONG,J.R.YATES,M.WINEY,S.J.SMERDON,M.B.YAFFE,A.AMONTITL ACTIVATION OF THE YEAST HIPPO PATHWAY BYTITL 2 PHOSPHORYLATION-DEPENDENT ASSEMBLY OF SIGNALING COMPLEXES.REF SCIENCE V. 340 871 2013REFN ISSN 0036-8075PMID 23579499DOI 10.1126/SCIENCE.1235822 Variant Set Distributions Mapped Variants
General Structure Information 2dkz GAREM solution structure of the sam_pnt-domain of the hypothetical protein loc64762 -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF THETITL 2 HYPOTHETICAL PROTEIN LOC64762REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dk6 PARP11 solution structure of wwe domain in poly (adp-ribose) polymerase family, member 11 (parp 11) -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF WWE DOMAIN IN POLYTITL 2 (ADP-RIBOSE) POLYMERASE FAMILY, MEMBER 11 (PARP 11)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants