Assessment of Structural Intolerance and Durability
General Structure Information 2dn6 SWAP70 solution structure of the ph domain of kiaa0640 protein from human -1.0Å AUTH H.LI,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF KIAA0640TITL 2 PROTEIN FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2da0 ASAP1 solution structure of the ph domain of pip2-dependent arf1 gtpase-activating protein from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OFTITL 2 PIP2-DEPENDENT ARF1 GTPASE-ACTIVATING PROTEIN FROMTITL 3 HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dhz RAPGEFL1 solution structure of the ra domain in the human link guanine nucleotide exchange factor ii (link-gefii) -1.0Å AUTH C.ZHAO,T.KIGAWA,M.YONEYAMA,S.KOSHIBA,T.HARADA,AUTH 2 S.WATANABE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RA DOMAIN IN THE HUMANTITL 2 LINK GUANINE NUCLEOTIDE EXCHANGE FACTOR IITITL 3 (LINK-GEFII)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4mqf GABBR1 crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist 2-hydroxysaclofen 2.22Å AUTH Y.GENG,M.BUSH,L.MOSYAK,F.WANG,Q.R.FANTITL STRUCTURAL MECHANISM OF LIGAND ACTIVATION IN HUMAN GABA(B)TITL 2 RECEPTOR.REF NATURE V. 504 254 2013REFN ISSN 0028-0836PMID 24305054DOI 10.1038/NATURE12725 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2c5l PLCE1 structure of plc epsilon ras association domain with hras 1.9Å AUTH T.D.BUNNEY,R.HARRIS,N.L.GANDARILLAS,M.B.JOSEPHS,AUTH 2 S.M.ROE,S.C.SORLI,H.F.PATERSON,F.RODRIGUES-LIMA,AUTH 3 D.ESPOSITO,C.P.PONTING,P.GIESCHIK,L.H.PEARL,AUTH 4 P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO RASTITL 2 ASSOCIATION DOMAINS OF PHOSPHOLIPASE C EPSILONREF MOL.CELL V. 21 495 2006REFN ISSN 1097-2765PMID 16483931DOI 10.1016/J.MOLCEL.2006.01.008 Variant Set Distributions Mapped Variants
General Structure Information 3mop IRAK4 the ternary death domain complex of myd88, irak4, and irak2 3.4Å AUTH S.C.LIN,Y.C.LO,H.WUTITL HELICAL ASSEMBLY IN THE MYD88-IRAK4-IRAK2 COMPLEX INTITL 2 TLR/IL-1R SIGNALLING.REF NATURE V. 465 885 2010REFN ISSN 0028-0836PMID 20485341DOI 10.1038/NATURE09121 Variant Set Distributions Mapped Variants
General Structure Information 3l46 ECT2 crystal structure of the second brct domain of epithelial cell transforming 2 (ect2) 1.48Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,H.WANG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE SECOND BRCT DOMAIN OF EPITHELIALTITL 2 CELL TRANSFORMING 2 (ECT2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3lq9 DDIT4 crystal strucure of human redd1, a hypoxia-induced regulator of mtor 2.0Å AUTH S.VEGA-RUBIN-DE-CELIS,Z.ABDALLAH,L.KINCH,AUTH 2 N.V.GRISHIN,J.BRUGAROLAS,X.ZHANGTITL STRUCTURAL ANALYSIS AND FUNCTIONAL IMPLICATIONS OFTITL 2 THE NEGATIVE MTORC1 REGULATOR REDD1.REF BIOCHEMISTRY V. 49 2491 2010REFN ISSN 0006-2960PMID 20166753DOI 10.1021/BI902135E Variant Set Distributions Mapped Variants
General Structure Information 3twr TNKS2 crystal structure of arc4 from human tankyrase 2 in complex with peptide from human 3bp2 1.55Å AUTH S.GUETTLER,J.LAROSE,E.PETSALAKI,G.GISH,A.SCOTTER,T.PAWSON,AUTH 2 R.ROTTAPEL,F.SICHERITITL STRUCTURAL BASIS AND SEQUENCE RULES FOR SUBSTRATETITL 2 RECOGNITION BY TANKYRASE EXPLAIN THE BASIS FOR CHERUBISMTITL 3 DISEASE.REF CELL(CAMBRIDGE,MASS.) V. 147 1340 2011REFN ISSN 0092-8674PMID 22153077DOI 10.1016/J.CELL.2011.10.046 Variant Set Distributions […]
General Structure Information 4e74 PLXNA4 crystal structure of the rho gtpase binding domain of plexin a4a 1.58Å AUTH X.GUAN,H.WANG,W.TEMPEL,A.DONG,Y.TONG,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 A4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants