Assessment of Structural Intolerance and Durability
General Structure Information 1×86 ARHGEF12 crystal structure of the dh/ph domains of leukemia-associated rhogef in complex with rhoa 3.22Å AUTH R.KRISTELLY,G.GAO,J.J.TESMERTITL STRUCTURAL DETERMINANTS OF RHOA BINDING AND NUCLEOTIDETITL 2 EXCHANGE IN LEUKEMIA-ASSOCIATED RHO GUANINE-NUCLEOTIDETITL 3 EXCHANGE FACTOR.REF J.BIOL.CHEM. V. 279 47352 2004REFN ISSN 0021-9258PMID 15331592DOI 10.1074/JBC.M406056200 Variant Set Distributions Mapped Variants
General Structure Information 2l5y STIM2 nmr structure of calcium-loaded stim2 ef-sam. -1.0Å AUTH L.ZHENG,P.B.STATHOPULOS,R.SCHINDL,G.Y.LI,C.ROMANIN,M.IKURATITL AUTO-INHIBITORY ROLE OF THE EF-SAM DOMAIN OF STIM PROTEINSTITL 2 IN STORE-OPERATED CALCIUM ENTRY.REF PROC.NATL.ACAD.SCI.USA V. 108 1337 2011REFN ISSN 0027-8424PMID 21217057DOI 10.1073/PNAS.1015125108 Variant Set Distributions Mapped Variants
General Structure Information 2ed1 ASAP1 solution structure of the sh3 domain of 130 kda phosphatidylinositol 4,5-biphosphate-dependent arf1 gtpase- activating protein -1.0Å AUTH H.ABE,N.TOCHIO,K.MIYAMOTO,K.SAITO,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF 130 KDATITL 2 PHOSPHATIDYLINOSITOL 4,5-BIPHOSPHATE-DEPENDENTTITL 3 ARF1 GTPASE-ACTIVATING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3c5c RASL12 crystal structure of human ras-like, family 12 protein in complex with gdp 1.85Å AUTH L.SHEN,Y.TONG,W.TEMPEL,P.LOPPNAU,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12TITL 2 PROTEIN IN COMPLEX WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2xmq NDRG2 crystal structure of human ndrg2 protein provides insight into its role as a tumor suppressor 2.81Å AUTH J.HWANG,Y.KIM,H.B.KANG,L.JAROSZEWSKI,A.DEACON,AUTH 2 H.LEE,W.C.CHOI,K.J.KIM,C.H.KIM,B.S.KANG,J.O.LEE,AUTH 3 T.K.OH,J.W.KIM,I.A.WILSON,M.H.KIMTITL CRYSTAL STRUCTURE OF HUMAN NDRG2 PROTEIN PROVIDESTITL 2 INSIGHT INTO ITS ROLE AS A TUMOR SUPPRESSOR.REF J.BIOL.CHEM. V. 286 12450 2011REFN ISSN 0021-9258PMID 21247902DOI 10.1074/JBC.M110.170803 Variant Set Distributions […]
General Structure Information 1ss6 NSFL1C solution structure of sep domain from human p47 -1.0Å AUTH M.SOUKENIK,A.DIEHL,M.LEIDERT,V.SIEVERT,K.BUESSOW,AUTH 2 D.LEITNER,D.LABUDDE,L.J.BALL,A.LECHNER,D.K.NAGLER,AUTH 3 H.OSCHKINATTITL THE SEP DOMAIN OF P47 ACTS AS A REVERSIBLETITL 2 COMPETITIVE INHIBITOR OF CATHEPSIN LREF FEBS LETT. V. 576 358 2004REFN ISSN 0014-5793PMID 15498563DOI 10.1016/J.FEBSLET.2004.09.037 Variant Set Distributions Mapped Variants
General Structure Information 2pkd CD84 crystal structure of cd84: insite into slam family function 2.04Å AUTH Q.YAN,V.N.MALASHKEVICH,A.FEDOROV,E.FEDOROV,E.CAO,AUTH 2 J.W.LARY,J.L.COLE,S.G.NATHENSON,S.C.ALMOTITL STRUCTURE OF CD84 PROVIDES INSIGHT INTO SLAMTITL 2 FAMILY FUNCTION.REF PROC.NATL.ACAD.SCI.USA V. 104 10583 2007REFN ISSN 0027-8424PMID 17563375DOI 10.1073/PNAS.0703893104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fb8 DAPP1 structure of the pleckstrin homology domain from dapp1/phish 2.4Å AUTH K.M.FERGUSON,J.M.KAVRAN,V.G.SANKARAN,E.FOURNIER,S.J.ISAKOFF,AUTH 2 E.Y.SKOLNIK,M.A.LEMMONTITL STRUCTURAL BASIS FOR DISCRIMINATION OF 3-PHOSPHOINOSITIDESTITL 2 BY PLECKSTRIN HOMOLOGY DOMAINS.REF MOL.CELL V. 6 373 2000REFN ISSN 1097-2765PMID 10983984DOI 10.1016/S1097-2765(00)00037-X Variant Set Distributions Mapped Variants
General Structure Information 2ee3 COL20A1 solution structures of the fn3 domain of human collagen alpha-1(xx) chain -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 COLLAGEN ALPHA-1(XX) CHAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3zrh ZRANB1 crystal structure of the lys29, lys33-linkage-specific trabid otu deubiquitinase domain reveals an ankyrin-repeat ubiquitin binding domain (ankubd) 2.23Å AUTH J.D.F.LICCHESI,J.MIESZCZANEK,T.E.T.MEVISSEN,T.J.RUTHERFORD,AUTH 2 M.AKUTSU,S.VIRDEE,F.E.OUALID,J.W.CHIN,H.OVAA,M.BIENZ,AUTH 3 D.KOMANDERTITL AN ANKYRIN-REPEAT UBIQUITIN-BINDING DOMAIN DETERMINESTITL 2 TRABIDS SPECIFICITY FOR ATYPICAL UBIQUITIN CHAINS.REF NAT.STRUCT.MOL.BIOL. V. 19 62 2011REFN ISSN 1545-9993PMID 22157957DOI 10.1038/NSMB.2169 Variant Set Distributions Ripley’s K […]