Assessment of Structural Intolerance and Durability
General Structure Information 2el8 STAP2 solution structure of the human stap2 sh2 domain -1.0Å AUTH T.KASAI,K.MIYAMOTO,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 S.WATANABE,T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN STAP2 SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1zv4 RGS17 structure of the regulator of g-protein signaling 17 (rgsz2) 2.4Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 1sko LAMTOR3 mp1-p14 complex 2.0Å AUTH V.V.LUNIN,C.MUNGER,J.WAGNER,Z.YE,M.CYGLER,M.SACHERTITL THE STRUCTURE OF THE MAP KINASE SCAFFOLD MP1 BOUNDTITL 2 TO ITS PARTNER P14: A COMPLEX WITH A CRITICAL ROLETITL 3 IN ENDOSOMAL MAP KINASE SIGNALINGREF J.BIOL.CHEM. V. 279 23422 2004REFN ISSN 0021-9258PMID 15016825DOI 10.1074/JBC.M401648200 Variant Set Distributions Mapped Variants
General Structure Information 4doh IL20RA il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4doh IL20 il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x1f STAP1 solution structure of the ph domain of human docking protein brdg1 -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF HUMANTITL 2 DOCKING PROTEIN BRDG1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3maz STAP1 crystal structure of the human brdg1/stap-1 sh2 domain in complex with the ntal ptyr136 peptide 1.9Å AUTH T.KANEKO,H.HUANG,B.ZHAO,L.LI,H.LIU,C.K.VOSS,C.WU,AUTH 2 M.R.SCHILLER,S.S.LITITL LOOPS GOVERN SH2 DOMAIN SPECIFICITY BY CONTROLLING ACCESSTITL 2 TO BINDING POCKETS.REF SCI.SIGNAL. V. 3 RA34 2010REFN ESSN 1937-9145PMID 20442417DOI 10.1126/SCISIGNAL.2000796 Variant Set Distributions Mapped Variants
General Structure Information 1×67 DBNL solution structure of the cofilin homology domain of hip-55 (drebrin-like protein) -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.SATO,AUTH 2 M.INOUE,S.WATANABE,Y.HAYASHIZAKI,A.TANAKA,T.KIGAWA,AUTH 3 S.YOKOYAMATITL NMR SOLUTION STRUCTURES OF ACTIN DEPOLYMERIZINGTITL 2 FACTOR HOMOLOGY DOMAINS.REF PROTEIN SCI. V. 18 2384 2009REFN ISSN 0961-8368PMID 19768801DOI 10.1002/PRO.248 Variant Set Distributions Mapped Variants
General Structure Information 4bld SUFU crystal structure of a human suppressor of fused (sufu)- gli3p complex 2.8Å AUTH A.L.CHERRY,C.FINTA,M.KARLSTROM,Q.JIN,T.SCHWEND,AUTH 2 J.ASTORGA-WELLS,R.A.ZUBAREV,M.DEL CAMPO,A.R.CRISWELL,AUTH 3 D.DE SANCTIS,L.JOVINE,R.TOFTGARDTITL STRUCTURAL BASIS OF SUFU-GLI INTERACTION IN HEDGEHOGTITL 2 SIGNALLING REGULATIONREF ACTA CRYSTALLOGR.,SECT.D V. 69 2579 2013REFN ISSN 0907-4449PMID 24311597DOI 10.1107/S0907444913028473 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2hak MARK1 catalytic and ubiqutin-associated domains of mark1/par-1 2.6Å AUTH A.MARX,C.NUGOOR,J.MUELLER,S.PANNEERSELVAM,T.TIMM,AUTH 2 M.BILANG,E.MYLONAS,D.I.SVERGUN,E.-M.MANDELKOW,AUTH 3 E.MANDELKOWTITL STRUCTURAL VARIATIONS IN THE CATALYTIC ANDTITL 2 UBIQUITIN-ASSOCIATED DOMAINS OFTITL 3 MICROTUBULE-ASSOCIATED PROTEIN/MICROTUBULETITL 4 AFFINITY REGULATING KINASE (MARK) 1 AND MARK2REF J.BIOL.CHEM. V. 281 27586 2006REFN ISSN 0021-9258PMID 16803889DOI 10.1074/JBC.M604865200 Variant Set Distributions Ripley’s K Analysis Plots […]