Assessment of Structural Intolerance and Durability
General Structure Information 2izs CSNK1G3 structure of casein kinase gamma 3 in complex with inhibitor 1.95Å AUTH G.BUNKOCZI,E.SALAH,P.RELLOS,S.DAS,O.FEDOROV,P.SAVITSKY,AUTH 2 J.E.DEBRECZENI,O.GILEADI,M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,AUTH 3 J.WEIGELT,F.VON DELFT,S.KNAPPTITL INHIBITOR BINDING BY CASEIN KINASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dad FHOD1 crystal structure of the n-terminal regulatory domains of the formin fhod1 2.3Å AUTH A.SCHULTE,B.STOLP,A.SCHONICHEN,O.PYLYPENKO,A.RAK,AUTH 2 O.T.FACKLER,M.GEYERTITL THE HUMAN FORMIN FHOD1 CONTAINS A BIPARTITETITL 2 STRUCTURE OF FH3 AND GTPASE-BINDING DOMAINSTITL 3 REQUIRED FOR ACTIVATION.REF STRUCTURE V. 16 1313 2008REFN ISSN 0969-2126PMID 18786395DOI 10.1016/J.STR.2008.06.008 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2yry PLEKHA6 solution structure of the ph domain of pleckstrin homology domain-containing family a member 6 from human -1.0Å AUTH H.LI,M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PLECKSTRINTITL 2 HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 6 FROMTITL 3 HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1p22 BTRC structure of a beta-trcp1-skp1-beta-catenin complex: destruction motif binding and lysine specificity on the scfbeta-trcp1 ubiquitin ligase 2.95Å AUTH G.WU,G.XU,B.A.SCHULMAN,P.D.JEFFREY,J.W.HARPER,AUTH 2 N.P.PAVLETICHTITL STRUCTURE OF A BETA-TRCP1-SKP1-BETA-CATENINTITL 2 COMPLEX: DESTRUCTION MOTIF BINDING AND LYSINETITL 3 SPECIFICITY OF THE SCFBETA-TRCP1 UBIQUITIN LIGASEREF MOL.CELL V. 11 1445 2003REFN ISSN 1097-2765PMID 12820959DOI 10.1016/S1097-2765(03)00234-X Variant Set […]
General Structure Information 2cu1 MAP3K2 solution structure of the pb1 domain of human protein kinase mekk2b -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PB1 DOMAIN OF HUMANTITL 2 PROTEIN KINASE MEKK2BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1lb6 TRAF6 traf6-cd40 complex 1.8Å AUTH H.YE,J.R.ARRON,B.LAMOTHE,M.CIRILLI,T.KOBAYASHI,AUTH 2 N.K.SHEVDE,D.SEGAL,O.K.DZIVENU,M.VOLOGODSKAIA,AUTH 3 M.YIM,K.DU,S.SINGH,J.W.PIKE,B.G.DARNAY,Y.CHOI,H.WUTITL DISTINCT MOLECULAR MECHANISM FOR INITIATING TRAF6TITL 2 SIGNALLING.REF NATURE V. 418 443 2002REFN ISSN 0028-0836PMID 12140561DOI 10.1038/NATURE00888 Variant Set Distributions Mapped Variants
General Structure Information 2vwf GAB2 grb2 sh3c (2) 1.58Å AUTH M.HARKIOLAKI,T.TSIRKA,M.LEWITZKY,P.C.SIMISTER,AUTH 2 D.JOSHI,L.E.BIRD,E.Y.JONES,N.OREILLY,S.M.FELLERTITL DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2TITL 2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2.REF STRUCTURE V. 17 809 2009REFN ISSN 0969-2126PMID 19523899DOI 10.1016/J.STR.2009.03.017 Variant Set Distributions Mapped Variants
General Structure Information 3ltl ARFGEF1 crystal structure of human big1 sec7 domain 2.2Å AUTH J.C.ZEEH,P.C.SIMISTER,V.ROUSSEAU,A.JOUBERT,J.CHERFILS,V.BIOUTITL THE SEC7 DOMAIN STRUCTURES OF HUMAN BIG1 AND CYTOHESIN1 ARFTITL 2 NUCLEOTIDE EXCHANGE FACTORSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d86 VAV3 solution structure of the ch domain from human vav-3 protein -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN FROM HUMANTITL 2 VAV-3 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ch9 KLHL3 crystal structure of the human klhl3 kelch domain in complex with a wnk4 peptide 1.84Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Mapped Variants