General Structure Information
| PDB ID | 1p22 |
| HGNC Gene Label(s) | BTRC |
| Structure Name | structure of a beta-trcp1-skp1-beta-catenin complex: destruction motif binding and lysine specificity on the scfbeta-trcp1 ubiquitin ligase |
| Resolution | 2.95Å |
| Reference | AUTH G.WU,G.XU,B.A.SCHULMAN,P.D.JEFFREY,J.W.HARPER,AUTH 2 N.P.PAVLETICHTITL STRUCTURE OF A BETA-TRCP1-SKP1-BETA-CATENINTITL 2 COMPLEX: DESTRUCTION MOTIF BINDING AND LYSINETITL 3 SPECIFICITY OF THE SCFBETA-TRCP1 UBIQUITIN LIGASEREF MOL.CELL V. 11 1445 2003REFN ISSN 1097-2765PMID 12820959DOI 10.1016/S1097-2765(03)00234-X |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 398 |
| Number Of SNVs | 69 |
| Number Of Permutations | 52750 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.098 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 398 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1348 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.286 |
| p-value | 0.289 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.169 |
| p-value | 0.389 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
