General Structure Information
| PDB ID | 2pz1 |
| HGNC Gene Label(s) | ARHGEF4 |
| Structure Name | crystal structure of auto-inhibited asef |
| Resolution | 2.25Å |
| Reference | AUTH N.MITIN,L.BETTS,M.E.YOHE,C.J.DER,J.SONDEK,K.L.ROSSMANTITL RELEASE OF AUTOINHIBITION OF ASEF BY APC LEADS TO CDC42TITL 2 ACTIVATION AND TUMOR SUPPRESSION.REF NAT.STRUCT.MOL.BIOL. V. 14 814 2007REFN ISSN 1545-9993PMID 17704816DOI 10.1038/NSMB1290 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 408 |
| Number Of SNVs | 84 |
| Number Of Permutations | 47720 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.044 |
| p-value | 0.237 |
COSMIC
| Number Of Residues | 408 |
| Number Of SNVs | 5 |
| Number Of Permutations | 325 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.2 |
| p-value | 0.634 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 84 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 39.0 |
| K Statistic | 0.216 |
| p-value | 0.677 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
