Assessment of Structural Intolerance and Durability
General Structure Information 3h8v UBA5 human ubiquitin-activating enzyme 5 in complex with atp 2.0Å AUTH J.P.BACIK,J.R.WALKER,M.ALI,A.D.SCHIMMER,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN UBIQUITIN-ACTIVATING ENZYME 5TITL 2 (UBA5) BOUND TO ATP: MECHANISTIC INSIGHTS INTO ATITL 3 MINIMALISTIC E1 ENZYME.REF J.BIOL.CHEM. V. 285 20273 2010REFN ISSN 0021-9258PMID 20368332DOI 10.1074/JBC.M110.102921 Variant Set Distributions Mapped Variants
General Structure Information 2b25 TRMT61B human putative trna(1-methyladenosine)methyltransferase 2.5Å AUTH H.WU,W.TEMPEL,A.DONG,H.ZENG,P.LOPPNAU,C.ARROWSMITH,AUTH 2 A.EDWARDS,J.WEIGELT,M.SUNDSTROM,A.BOCHKAREV,A.N.PLOTNIKOVTITL HUMAN PUTATIVE TRNA(1-METHYLADENOSINE)METHYLTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3o4r DHRS4 crystal structure of human dehydrogenase/reductase (sdr family) member 4 (dhrs4) 1.7Å AUTH E.UGOCHUKWU,C.BHATIA,T.KROJER,M.VOLLMAR,W.W.YUE,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN DEHYDROGENASE/REDUCTASE (SDRTITL 2 FAMILY) MEMBER 4 (DHRS4)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3op5 VRK1 human vaccinia-related kinase 1 2.4Å AUTH C.K.ALLERSTON,S.UTTARKAR,P.SAVITSKY,J.M.ELKINS,AUTH 2 P.FILIPPAKOPOULOS,T.KROJER,P.RELLOS,O.FEDOROV,J.ESWARAN,AUTH 3 B.BRENNER,T.KEATES,S.DAS,O.KING,R.CHALK,G.BERRIDGE,AUTH 4 F.VON DELFT,O.GILEADI,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 5 C.BOUNTRA,S.KNAPPTITL HUMAN VACCINIA-RELATED KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i2n WDR92 crystal structure of wd40 repeats protein wdr92 1.95Å AUTH C.XU,J.MINTITL STRUCTURE AND FUNCTION OF WD40 DOMAIN PROTEINS.REF PROTEIN CELL V. 2 202 2011REFN ISSN 1674-800XPMID 21468892DOI 10.1007/S13238-011-1018-1 Variant Set Distributions Mapped Variants
General Structure Information 2r4h MAGI1 crystal structure of a c1190s mutant of the 6th pdz domain of human membrane associated guanylate kinase 2.05Å AUTH E.UGOCHUKWU,E.S.PILKA,V.HOZJAN,K.L.KAVANAGH,C.COOPER,AUTH 2 A.C.W.PIKE,J.M.ELKINS,D.A.DOYLE,F.VON DELFT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF A C1190S MUTANT OF THE 6TH PDZ DOMAINTITL 2 OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 2bmj AGAP2 gtpase like domain of centaurin gamma 1 (human) 2.1Å AUTH M.SOUNDARARAJAN,X.YANG,J.M.ELKINS,F.SOBOTT,D.A.DOYLETITL THE CENTAURIN GAMMA-1 GTPASE-LIKE DOMAIN FUNCTIONS AS ANTITL 2 NTPASE.REF BIOCHEM.J. V. 401 679 2007REFN ISSN 0264-6021PMID 17037982DOI 10.1042/BJ20060555 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kuq DLC1 crystal structure of the dlc1 rhogap domain 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,F.MACKENZIE,L.SHEN,AUTH 2 N.ZHONG,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE DLC1 RHOGAP DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2b9e NSUN5 human nsun5 protein 1.65Å AUTH J.R.MIN,H.WU,H.ZENG,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN NSUN5 PROTEIN INTITL 2 COMPLEX WITH S-ADENOSYL-L-METHIONINEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r2q GABARAPL1 crystal structure of human gamma-aminobutyric acid receptor- associated protein-like 1 (gabarap1), isoform cra_a 1.65Å AUTH R.PARAMANATHAN,T.DAVIS,W.TEMPEL,S.MUJIB,AUTH 2 C.BUTLER-COLE,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF HUMAN GAMMA-AMINOBUTYRIC ACIDTITL 2 RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (GABARAP1),TITL 3 ISOFORM CRA_A.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants