General Structure Information
| PDB ID | 2b9e |
| HGNC Gene Label(s) | NSUN5 |
| Structure Name | human nsun5 protein |
| Resolution | 1.65Å |
| Reference | AUTH J.R.MIN,H.WU,H.ZENG,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN NSUN5 PROTEIN INTITL 2 COMPLEX WITH S-ADENOSYL-L-METHIONINEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 275 |
| Number Of SNVs | 79 |
| Number Of Permutations | 10968 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.278 |
| p-value | 0.691 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 7:72721492 | Q>H | A:133 | (20.09, -43.08, 19.07) | |
| 7:72721476 | R>C | A:139 | (23.89, -27.68, 5.59) | |
| 7:72721469 | N>T | A:141 | (25.70, -26.53, 0.03) | |
| 7:72721447 | D>E | A:148 | (14.13, -28.74, -5.33) | |
| 7:72721449 | rs146814551 | D>N | A:148 | (14.13, -28.74, -5.33) |
| 7:72721446 | COSM3942290 COSM3942289 |
D>N | A:149 | (18.13, -30.56, -7.23) |
| 7:72721423 | R>S | A:156 | (15.31, -39.99, -9.81) | |
| 7:72721422 | Q>K | A:157 | (18.57, -43.24, -4.49) | |
| 7:72721418 | G>A | A:158 | (13.67, -44.60, -3.26) | |
| 7:72721419 | rs143290632 | G>R | A:158 | (13.67, -44.60, -3.26) |
| 7:72721400 | rs149127343 | R>Q | A:164 | (9.30, -28.30, 6.21) |
| 7:72721401 | R>W | A:164 | (9.30, -28.30, 6.21) | |
| 7:72721397 | A>V | A:165 | (7.76, -31.09, 9.28) | |
| 7:72719090 | COSM1091526 COSM1091525 |
D>N | A:169 | (6.41, -36.19, 17.02) |
| 7:72719048 | rs34913552 | P>S | A:183 | (10.33, -28.26, 11.42) |
| 7:72718843 | A>V | A:219 | (24.50, -18.96, 11.32) | |
| 7:72718830 | COSM3984000 COSM3983999 |
D>E | A:223 | (21.43, -13.32, 8.94) |
| 7:72718829 | P>T | A:224 | (25.31, -12.91, 7.66) | |
| 7:72718825 | P>L | A:225 | (24.70, -9.86, 4.94) | |
| 7:72718808 | I>V | A:231 | (35.14, -13.00, 12.93) | |
| 7:72718805 | D>N | A:232 | (34.58, -18.25, 12.91) | |
| 7:72718790 | P>S | A:237 | (35.92, -28.51, 11.89) | |
| 7:72718783 | N>S | A:239 | (30.56, -27.50, 10.22) | |
| 7:72718774 | S>T | A:242 | (30.01, -23.77, 5.82) | |
| 7:72718775 | S>G | A:242 | (30.01, -23.77, 5.82) | |
| 7:72718772 | H>D | A:243 | (25.45, -22.26, 7.64) | |
| 7:72718760 | L>V | A:247 | (24.02, -17.48, 4.74) | |
| 7:72718403 | K>M | A:253 | (36.09, -11.99, 3.32) | |
| 7:72718380 | A>T | A:261 | (46.10, -28.59, 12.98) | |
| 7:72718373 | COSM3788302 COSM3788301 |
R>Q | A:263 | (39.20, -29.70, 15.01) |
| 7:72718374 | R>W | A:263 | (39.20, -29.70, 15.01) | |
| 7:72718362 | M>L | A:267 | (38.21, -26.17, 7.96) | |
| 7:72718355 | T>M | A:269 | (38.63, -30.93, 3.35) | |
| 7:72718350 | L>V | A:271 | (35.85, -25.04, 3.37) | |
| 7:72718347 | A>S | A:272 | (36.59, -27.35, -0.68) | |
| 7:72718343 | rs113605106 | R>Q | A:273 | (32.89, -31.32, 0.70) |
| 7:72718341 | A>T | A:274 | (31.59, -26.78, -0.15) | |
| 7:72718335 | V>I | A:276 | (34.07, -22.15, 0.57) | |
| 7:72718326 | C>R | A:279 | (37.69, -18.27, 4.07) | |
| 7:72718310 | E>G | A:284 | (45.85, -16.82, 14.58) | |
| 7:72718308 | D>N | A:285 | (44.96, -16.88, 20.01) | |
| 7:72718298 | A>V | A:288 | (45.78, -12.40, 19.36) | |
| 7:72718299 | A>T | A:288 | (45.78, -12.40, 19.36) | |
| 7:72718286 | S>L | A:292 | (42.91, -2.42, 15.93) | |
| 7:72718282 | D>E | A:293 | (43.91, -5.33, 12.36) | |
| 7:72718277 | R>H | A:295 | (43.69, -7.90, 8.79) | |
| 7:72718278 | rs77133388 | R>C | A:295 | (43.69, -7.90, 8.79) |
| 7:72718271 | H>R | A:297 | (37.79, -1.86, 8.95) | |
| 7:72718266 | V>L | A:299 | (33.88, -7.10, 11.25) | |
| 7:72717979 | R>H | A:330 | (37.21, -30.55, 30.62) | |
| 7:72717973 | H>R | A:332 | (36.11, -23.81, 36.89) | |
| 7:72717962 | G>R | A:336 | (37.42, -18.60, 31.04) | |
| 7:72717949 | R>Q | A:340 | (39.65, -15.30, 28.54) | |
| 7:72717940 | C>Y | A:343 | (34.88, -9.96, 26.36) | |
| 7:72717928 | T>I | A:347 | (36.25, -5.25, 21.67) | |
| 7:72717925 | F>Y | A:348 | (36.42, -6.86, 17.32) | |
| 7:72717922 | P>R | A:349 | (35.28, -1.93, 16.21) | |
| 7:72717914 | Q>E | A:352 | (26.33, -4.67, 13.81) | |
| 7:72717910 | R>Q | A:353 | (23.85, -9.65, 14.77) | |
| 7:72717911 | R>W | A:353 | (23.85, -9.65, 14.77) | |
| 7:72717908 | L>V | A:354 | (27.94, -12.10, 18.86) | |
| 7:72717895 | T>M | A:358 | (27.86, -24.07, 23.84) | |
| 7:72717889 | S>C | A:360 | (26.97, -27.09, 27.40) | |
| 7:72717875 | E>K | A:365 | (30.09, -23.50, 29.94) | |
| 7:72717863 | V>M | A:369 | (29.55, -16.39, 29.97) | |
| 7:72717859 | rs148120256 | V>A | A:370 | (26.21, -14.03, 28.54) |
| 7:72717856 | R>Q | A:371 | (25.98, -13.18, 34.33) | |
| 7:72717850 | A>V | A:373 | (29.87, -10.01, 29.23) | |
| 7:72717835 | COSM1091518 COSM1091517 |
P>L | A:378 | (27.28, -1.61, 30.92) |
| 7:72717832 | G>D | A:379 | (24.66, -0.80, 27.22) | |
| 7:72717830 | A>T | A:380 | (26.53, -1.79, 24.62) | |
| 7:72717733 | A>P | A:384 | (18.17, -10.89, 21.08) | |
| 7:72717726 | A>V | A:386 | (15.59, -15.97, 19.66) | |
| 7:72717727 | A>T | A:386 | (15.59, -15.97, 19.66) | |
| 7:72717720 | P>L | A:388 | (10.32, -17.49, 18.99) | |
| 7:72717718 | rs147944881 | A>P | A:389 | (9.54, -21.48, 17.78) |
| 7:72717715 | rs4030982 | W>R | A:390 | (14.52, -24.12, 19.40) |
| 7:72717711 | COSM3640288 COSM3640287 |
P>L | A:391 | (10.72, -24.47, 22.78) |
| 7:72717705 | R>Q | A:393 | (14.19, -20.30, 25.15) | |
| 7:72717687 | P>L | A:399 | (17.48, -10.16, 33.28) | |
| 7:72717688 | P>A | A:399 | (17.48, -10.16, 33.28) | |
| 7:72717681 | rs142504807 | A>G | A:401 | (17.93, -15.29, 29.49) |
| 7:72717666 | rs147725314 | R>Q | A:406 | (19.75, -24.45, 27.19) |
| 7:72717667 | R>W | A:406 | (19.75, -24.45, 27.19) | |
| 7:72717663 | A>V | A:407 | (19.27, -28.08, 23.58) | |
| 7:72717654 | E>A | A:410 | (15.66, -35.55, 25.55) | |
| 7:72717640 | rs2353056 | S>G | A:415 | (23.12, -31.61, 21.01) |
| 7:72717627 | V>A | A:419 | (22.32, -19.85, 21.43) | |
| 7:72717628 | V>I | A:419 | (22.32, -19.85, 21.43) | |
| 7:72717622 | V>I | A:421 | (21.60, -13.36, 19.92) | |
| 7:72717612 | R>Q | A:424 | (25.62, -1.96, 17.68) | |
| 7:72717613 | R>W | A:424 | (25.62, -1.96, 17.68) |