2B25.B | TRMT61B

General Structure Information

PDB ID	2b25
HGNC Gene Label(s)	TRMT61B
Structure Name	human putative trna(1-methyladenosine)methyltransferase
Resolution	2.5Å
Reference	AUTH H.WU,W.TEMPEL,A.DONG,H.ZENG,P.LOPPNAU,C.ARROWSMITH,AUTH 2 A.EDWARDS,J.WEIGELT,M.SUNDSTROM,A.BOCHKAREV,A.N.PLOTNIKOVTITL HUMAN PUTATIVE TRNA(1-METHYLADENOSINE)METHYLTRANSFERASEREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	239
Number Of SNVs	67
Number Of Permutations	12241
Optimal Distance Threshold	11.0
K Statistic	0.1
p-value	0.855

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:29092695		P>R	B:7	(-24.25, 78.61, 23.87)
2:29092696	rs552009834 COSM3580879	P>A	B:7	(-24.25, 78.61, 23.87)
2:29092687		A>S	B:10	(-24.06, 78.31, 14.12)
2:29092664	rs140115429	E>D	B:17	(-21.11, 60.67, 22.51)
2:29092666		E>K	B:17	(-21.11, 60.67, 22.51)
2:29092645		K>E	B:24	(-19.64, 54.15, 21.34)
2:29092628		F>L	B:29	(-22.01, 67.98, 14.00)
2:29092619		N>K	B:32	(-26.87, 73.88, 10.25)
2:29092571	rs529935902	K>N	B:48	(-33.09, 70.91, 18.89)
2:29092573	rs113838676	K>E	B:48	(-33.09, 70.91, 18.89)
2:29092567		V>L	B:50	(-29.16, 75.68, 19.17)
2:29092518		Y>C	B:66	(-27.63, 61.39, 19.89)
2:29092515		M>T	B:67	(-23.57, 63.80, 24.82)
2:29092504		P>T	B:71	(-14.70, 69.14, 20.17)
2:29092501		A>S	B:72	(-11.41, 67.85, 22.13)
2:29092488		Y>C	B:76	(-10.26, 67.98, 15.06)
2:29092475		M>I	B:80	(-9.40, 65.14, 11.55)
2:29092468		G>R	B:83	(-4.15, 61.24, 4.72)
2:29092464		T>S	B:84	(-2.36, 60.17, 7.29)
2:29092450		P>S	B:89	(-4.05, 60.80, 21.35)
2:29092447		K>E	B:90	(-1.70, 56.60, 23.03)
2:29087982		I>V	B:92	(0.55, 62.82, 20.58)
2:29087975	rs140202814	M>T	B:94	(4.61, 59.96, 25.98)
2:29087976		M>V	B:94	(4.61, 59.96, 25.98)
2:29087964	rs369163969	M>V	B:98	(9.49, 62.11, 25.77)
2:29087959		M>I	B:99	(9.40, 67.13, 23.61)
2:29087961		M>V	B:99	(9.40, 67.13, 23.61)
2:29087951	rs553131828	N>S	B:102	(7.58, 74.58, 28.71)
2:29087952		N>H	B:102	(7.58, 74.58, 28.71)
2:29087921		S>L	B:112	(2.70, 67.57, 9.04)
2:29087919		G>C	B:113	(0.34, 65.38, 7.73)
2:29087915	rs142987566	S>F	B:114	(-3.16, 65.20, 8.95)
2:29087916	rs185574768	S>P	B:114	(-3.16, 65.20, 8.95)
2:29084157		V>I	B:131	(5.36, 75.27, 15.64)
2:29084154		I>L	B:132	(8.79, 75.28, 12.69)
2:29084143		E>D	B:135	(4.70, 67.67, 4.50)
2:29084138		R>Q	B:137	(2.64, 64.18, 0.04)
2:29084128		H>Q	B:140	(-0.49, 64.99, 2.95)
2:29084126		H>R	B:141	(1.17, 71.85, 3.37)
2:29084123		D>G	B:142	(-2.82, 71.74, 1.62)
2:29084115		K>Q	B:145	(-2.37, 74.98, 6.10)
2:29084093	rs371841780	R>H	B:152	(-7.50, 79.34, 14.66)
2:29084089		D>E	B:153	(-12.28, 79.10, 12.28)
2:29084074	rs200840184	S>R	B:158	(-16.42, 79.14, 21.45)
2:29084069	rs376670677	V>A	B:160	(-12.72, 85.05, 23.15)
2:29084062		E>D	B:162	(-6.99, 84.09, 19.32)
2:29084063		E>G	B:162	(-6.99, 84.09, 19.32)
2:29084064		E>Q	B:162	(-6.99, 84.09, 19.32)
2:29084061		W>R	B:163	(-5.84, 77.40, 19.48)
2:29084055	rs199699822	D>N	B:165	(-1.29, 81.65, 14.42)
2:29083992	rs146514468	F>I	B:186	(14.57, 74.45, 17.04)
2:29083986	rs140170079	A>S	B:188	(12.24, 70.54, 20.56)
2:29075353	rs376462257	M>V	B:193	(9.61, 60.99, 9.08)
2:29075350	rs144366859	L>I	B:194	(9.59, 56.87, 6.76)
2:29075344	COSM1720781	P>A	B:196	(14.15, 59.41, 10.84)
2:29075313	rs562662692	H>R	B:206	(20.00, 74.83, 14.25)
2:29075311	rs369790293	L>V	B:207	(18.68, 71.09, 19.25)
2:29075302		G>S	B:210	(19.24, 69.18, 26.16)
2:29075298	rs544349249	G>A	B:211	(17.38, 68.56, 23.98)
2:29075291	rs201285210	C>W	B:213	(14.42, 64.17, 19.49)
2:29075293		C>R	B:213	(14.42, 64.17, 19.49)
2:29075290		A>T	B:214	(10.89, 62.74, 19.50)
2:29075286	rs375583868	V>A	B:215	(11.01, 59.52, 17.21)
2:29075287		V>I	B:215	(11.01, 59.52, 17.21)
2:29075283		Y>C	B:216	(5.14, 57.54, 15.66)
2:29074156		Q>L	B:222	(11.71, 51.65, 11.79)
2:29074157		Q>E	B:222	(11.71, 51.65, 11.79)
2:29074144		L>P	B:226	(17.25, 56.01, 14.73)
2:29074141	rs150890124	L>S	B:227	(19.90, 53.92, 17.35)
2:29074129	rs149852767	R>H	B:231	(27.39, 53.78, 15.74)
2:29074130	COSM1407599	R>C	B:231	(27.39, 53.78, 15.74)
2:29074121	rs148229061	E>K	B:234	(28.75, 61.00, 14.92)
2:29074117		L>P	B:235	(25.18, 62.67, 15.70)
2:29074118		L>F	B:235	(25.18, 62.67, 15.70)
2:29074088	rs373614725	V>I	B:245	(1.71, 53.67, 25.09)
2:29074085		I>F	B:246	(-0.43, 49.87, 26.44)
2:29074078		R>K	B:248	(-6.63, 46.84, 29.40)
2:29074061	rs143440153	L>I	B:254	(-25.89, 47.54, 36.60)
2:29073205		P>R	B:317	(-6.75, 48.79, 20.57)
2:29073202		G>D	B:318	(-3.15, 47.91, 18.93)
2:29073090		R>K	B:327	(18.29, 64.52, 26.10)