Assessment of Structural Intolerance and Durability
General Structure Information 3i6w CHEK2 structure and activation mechanism of the chk2 dna-damage checkpoint kinase 3.25Å AUTH Z.CAI,N.H.CHEHAB,N.P.PAVLETICHTITL STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA DAMAGETITL 2 CHECKPOINT KINASE.REF MOL.CELL V. 35 818 2009REFN ISSN 1097-2765PMID 19782031DOI 10.1016/J.MOLCEL.2009.09.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lm0 STK17B crystal structure of human serine/threonine kinase 17b (stk17b) 2.35Å Variant Set Distributions Mapped Variants
General Structure Information 2buj STK16 crystal structure of the human serine-threonine kinase 16 in complex with staurosporine 2.6Å AUTH J.E.DEBRECZENI,J.ESWARAN,A.BULLOCK,P.FILIPPAKOPOULOS,AUTH 2 K.KAVANAGH,A.AMOS,O.FEDOROV,F.SOBOTT,L.J.BALL,F.VON DELFT,AUTH 3 C.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16TITL 2 IN COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3bqr DAPK3 crystal structure of human death associated protein kinase 3 (dapk3) in complex with an imidazo-pyridazine ligand 1.75Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,O.FEDOROV,F.NIESEN,A.C.W.PIKE,AUTH 2 E.S.PILKA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3TITL 2 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4f9a CDC7 human cdc7 kinase in complex with dbf4 and nucleotide 2.17Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3cok PLK4 crystal structure of plk4 kinase 2.25Å AUTH S.ATWELL,S.K.BURLEY,A.HOULE,B.LEON,L.A.PELLETIER,AUTH 2 J.M.SAUDERTITL CRYSTAL STRUCTURE OF PLK4 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r5t SGK1 crystal structure of inactive serum and glucocorticoid- regulated kinase 1 in complex with amp-pnp 1.9Å AUTH B.ZHAO,R.LEHR,A.M.SMALLWOOD,T.F.HO,K.MALEY,AUTH 2 T.RANDALL,M.S.HEAD,K.K.KORETKE,C.G.SCHNACKENBERGTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF SERUMTITL 2 AND GLUCOCORTICOID-REGULATED KINASE 1 IN COMPLEXTITL 3 WITH AMP PNP.REF PROTEIN SCI. V. 16 2761 2007REFN ISSN 0961-8368PMID 17965184DOI 10.1110/PS.073161707 Variant Set […]