Assessment of Structural Intolerance and Durability
General Structure Information 2xwb CFB crystal structure of complement c3b in complex with factors b and d 3.49Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3f6u PROC crystal structure of human activated protein c (apc) complexed with ppack 2.8Å AUTH A.E.SCHMIDT,K.PADMANABHAN,M.C.UNDERWOOD,W.BODE,T.MATHER,AUTH 2 S.P.BAJAJTITL THERMODYNAMIC LINKAGE BETWEEN THE S1 SITE, THE NA+ SITE, ANDTITL 2 THE CA2+ SITE IN THE PROTEASE DOMAIN OF HUMAN ACTIVATEDTITL 3 PROTEIN C (APC).REF J.BIOL.CHEM. V. 277 28987 2002REFN ISSN 0021-9258PMID 12029084DOI 10.1074/JBC.M201892200 […]
General Structure Information 3nxp F2 crystal structure of human prethrombin-1 2.2Å AUTH Z.CHEN,L.A.PELC,E.DI CERATITL CRYSTAL STRUCTURE OF PRETHROMBIN-1.REF PROC.NATL.ACAD.SCI.USA V. 107 19278 2010REFN ISSN 0027-8424PMID 20974933DOI 10.1073/PNAS.1010262107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rtf PLAT complex of benzamidine with the catalytic domain of human two chain tissue plasminogen activator [(tc)-t-pa] 2.3Å AUTH D.LAMBA,M.BAUER,R.HUBER,S.FISCHER,R.RUDOLPH,AUTH 2 U.KOHNERT,W.BODETITL THE 2.3 A CRYSTAL STRUCTURE OF THE CATALYTICTITL 2 DOMAIN OF RECOMBINANT TWO-CHAIN HUMAN TISSUE-TYPETITL 3 PLASMINOGEN ACTIVATORREF J.MOL.BIOL. V. 258 117 1996REFN ISSN 0022-2836PMID 8613982DOI 10.1006/JMBI.1996.0238 Variant Set Distributions […]
General Structure Information 2vwm F10 aminopyrrolidine factor xa inhibitor 1.96Å AUTH K.G.ZBINDEN,L.ANSELM,D.W.BANNER,J.M.BENZ,F.BLASCO,AUTH 2 G.DECORET,J.HIMBER,B.KUHN,N.PANDAY,F.RICKLIN,AUTH 3 P.RISCH,D.SCHLATTER,M.STAHL,S.THOMI,R.UNGER,W.HAAPTITL DESIGN OF NOVEL AMINOPYRROLIDINE FACTOR XATITL 2 INHIBITORS FROM A SCREENING HIT.REF EUR.J.MED.CHEM. V. 44 2787 2009REFN ISSN 0223-5234PMID 19200624DOI 10.1016/J.EJMECH.2008.12.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xrc CFI human complement factor i 2.69Å AUTH P.ROVERSI,S.JOHNSON,J.J.CAESAR,F.MCLEAN,K.J.LEATH,AUTH 2 S.A.TSIFTSOGLOU,B.P.MORGAN,C.L.HARRIS,R.B.SIM,S.M.LEATITL STRUCTURAL BASIS FOR COMPLEMENT FACTOR I CONTROL AND ITSTITL 2 DISEASE-ASSOCIATED SEQUENCE POLYMORPHISMS.REF PROC.NATL.ACAD.SCI.USA V. 108 12839 2011REFN ISSN 0027-8424PMID 21768352DOI 10.1073/PNAS.1102167108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bt1 PLAU structure of urokinase receptor, urokinase and vitronectin complex 2.8Å AUTH Q.HUAI,A.ZHOU,L.LIN,A.P.MAZAR,G.C.PARRY,J.CALLAHAN,D.E.SHAW,AUTH 2 B.FURIE,B.C.FURIE,M.HUANGTITL CRYSTAL STRUCTURES OF TWO HUMAN VITRONECTIN, UROKINASE ANDTITL 2 UROKINASE RECEPTOR COMPLEXESREF NAT.STRUCT.MOL.BIOL. V. 15 422 2008REFN ISSN 1545-9993PMID 18376415DOI 10.1038/NSMB.1404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xwj C3 crystal structure of complement c3b in complex with factor b 4.0Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3ee6 TPP1 crystal structure analysis of tripeptidyl peptidase -i 2.35Å AUTH A.PAL,R.KRAETZNER,T.GRUENE,M.GRAPP,K.SCHREIBER,M.GRONBORG,AUTH 2 H.URLAUB,S.BECKER,A.R.ASIF,J.GARTNER,G.M.SHELDRICK,AUTH 3 R.STEINFELDTITL STRUCTURE OF TRIPEPTIDYL-PEPTIDASE I PROVIDES INSIGHT INTOTITL 2 THE MOLECULAR BASIS OF LATE INFANTILE NEURONAL CEROIDTITL 3 LIPOFUSCINOSISREF J.BIOL.CHEM. V. 284 3976 2009REFN ISSN 0021-9258PMID 19038966DOI 10.1074/JBC.M806947200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1lcy HTRA2 crystal structure of the mitochondrial serine protease htra2 2.0Å AUTH W.LI,S.M.SRINIVASULA,J.CHAI,P.LI,J.W.WU,Z.ZHANG,E.S.ALNEMRI,AUTH 2 Y.SHITITL STRUCTURAL INSIGHTS INTO THE PRO-APOPTOTIC FUNCTION OFTITL 2 MITOCHONDRIAL SERINE PROTEASE HTRA2/OMI.REF NAT.STRUCT.BIOL. V. 9 436 2002REFN ISSN 1072-8368PMID 11967569DOI 10.1038/NSB795 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants