Assessment of Structural Intolerance and Durability
General Structure Information 3tk9 GZMH crystal structure of human granzyme h 2.2Å AUTH L.WANG,K.ZHANG,L.WU,S.LIU,H.ZHANG,Q.ZHOU,L.TONG,F.SUN,Z.FANTITL STRUCTURAL INSIGHTS INTO THE SUBSTRATE SPECIFICITY OF HUMANTITL 2 GRANZYME H: THE FUNCTIONAL ROLES OF A NOVEL RKR MOTIFREF J.IMMUNOL. V. 188 765 2012REFN ISSN 0022-1767PMID 22156497DOI 10.4049/JIMMUNOL.1101381 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1fuj PRTN3 pr3 (myeloblastin) 2.2Å AUTH M.FUJINAGA,M.M.CHERNAIA,R.HALENBECK,K.KOTHS,M.N.JAMESTITL THE CRYSTAL STRUCTURE OF PR3, A NEUTROPHIL SERINE PROTEINASETITL 2 ANTIGEN OF WEGENERS GRANULOMATOSIS ANTIBODIES.REF J.MOL.BIOL. V. 261 267 1996REFN ISSN 0022-2836PMID 8757293DOI 10.1006/JMBI.1996.0458 Variant Set Distributions Mapped Variants
General Structure Information 1wun F3 human factor viia-tissue factor complexed with ethylsulfonamide-d-trp-gln-p-aminobenzamidine 2.4Å AUTH S.KADONO,A.SAKAMOTO,Y.KIKUCHI,M.OH-EDA,N.YABUTA,AUTH 2 K.YOSHIHASHI,T.KITAZAWA,T.SUZUKI,T.KOGA,K.HATTORI,AUTH 3 T.SHIRAISHI,M.HARAMURA,H.KODAMA,Y.ONO,T.ESAKI,AUTH 4 H.SATO,Y.WATANABE,S.ITOH,M.OHTA,T.KOZONOTITL STRUCTURE-BASED DESIGN OF P3 MOIETIES IN THETITL 2 PEPTIDE MIMETIC FACTOR VIIA INHIBITORREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 327 589 2005REFN ISSN 0006-291XPMID 15629154DOI 10.1016/J.BBRC.2004.12.042 Variant Set Distributions Mapped Variants
General Structure Information 1spj KLK1 structure of mature human tissue kallikrein (human kallikrein 1 or klk1) at 1.70 angstrom resolution with vacant active site 1.7Å AUTH G.LAXMIKANTHAN,S.I.BLABER,M.J.BERNETT,I.A.SCARISBRICK,AUTH 2 M.A.JULIANO,M.BLABERTITL 1.70 A X-RAY STRUCTURE OF HUMAN APO KALLIKREIN 1: STRUCTURALTITL 2 CHANGES UPON PEPTIDE INHIBITOR/SUBSTRATE BINDINGREF PROTEINS V. 58 802 2005REFN ISSN 0887-3585PMID 15651049DOI 10.1002/PROT.20368 Variant […]
General Structure Information 1kyn CTSG cathepsin-g 3.5Å AUTH M.N.GRECO,M.J.HAWKINS,E.T.POWELL,H.R.ALMOND JR.,AUTH 2 T.W.CORCORAN,L.DE GARAVILLA,J.A.KAUFFMAN,R.RECACHA,AUTH 3 D.CHATTOPADHYAY,P.ANDRADE-GORDON,B.E.MARYANOFFTITL NONPEPTIDE INHIBITORS OF CATHEPSIN G: OPTIMIZATIONTITL 2 OF A NOVEL BETA-KETOPHOSPHONIC ACID LEAD BYTITL 3 STRUCTURE-BASED DRUG DESIGN.REF J.AM.CHEM.SOC. V. 124 3810 2002REFN ISSN 0002-7863PMID 11942800DOI 10.1021/JA017506H Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3th4 F7 mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+ 1.8Å AUTH K.VADIVEL,S.AGAH,A.MESSER,D.CASCIO,S.M.BAJAJ,S.KRISHNASWAMY,AUTH 2 C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THETITL 2 GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMINTITL 3 K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+REF TO BE PUBLISHEDREFN […]
General Structure Information 4mwt CTSA crystal structure of human ppca (trigonal crystal form 2) 3.85Å AUTH N.KOLLI,S.C.GARMANTITL PROTEOLYTIC ACTIVATION OF HUMAN CATHEPSIN A.REF J.BIOL.CHEM. V. 289 11592 2014REFN ISSN 0021-9258PMID 24599961DOI 10.1074/JBC.M113.524280 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qum KLK3 crystal structure of human prostate specific antigen (psa) in fab sandwich with a high affinity and a pca selective antibody 3.2Å AUTH E.A.STURA,B.H.MULLER,M.BOSSUS,S.MICHEL,C.JOLIVET-REYNAUD,AUTH 2 F.DUCANCELTITL CRYSTAL STRUCTURE OF HUMAN PROSTATE-SPECIFIC ANTIGEN IN ATITL 2 SANDWICH ANTIBODY COMPLEX.REF J.MOL.BIOL. V. 414 530 2011REFN ISSN 0022-2836PMID 22037582DOI 10.1016/J.JMB.2011.10.007 Variant Set Distributions Ripley’s […]
General Structure Information 1b0f ELANE crystal structure of human neutrophil elastase with mdl 101, 146 3.0Å AUTH R.J.CREGGE,S.L.DURHAM,R.A.FARR,S.L.GALLION,C.M.HARE,AUTH 2 R.V.HOFFMAN,M.J.JANUSZ,H.O.KIM,J.R.KOEHL,S.MEHDI,W.A.METZ,AUTH 3 N.P.PEET,J.T.PELTON,H.A.SCHREUDER,S.SUNDER,C.TARDIFTITL INHIBITION OF HUMAN NEUTROPHIL ELASTASE. 4. DESIGN,TITL 2 SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, ANDTITL 3 STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OFTITL 4 P2-MODIFIED, ORALLY ACTIVE PEPTIDYL PENTAFLUOROETHYLTITL 5 KETONES.REF J.MED.CHEM. V. 41 2461 1998REFN […]
General Structure Information 2xwb C3 crystal structure of complement c3b in complex with factors b and d 3.49Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots […]