Assessment of Structural Intolerance and Durability
General Structure Information 3i3n KLHL11 crystal structure of the btb-back domains of human klhl11 2.6Å AUTH J.W.MURRAY,C.D.O.COOPER,T.KROJER,P.MAHAJAN,E.SALAH,AUTH 2 T.KEATES,P.SAVITSKY,A.C.W.PIKE,A.ROOS,J.MUNIZ,AUTH 3 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 4 A.EDWARDS,S.KNAPP,A.BULLOCK,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMANTITL 2 KLHL11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3twr TNKS2 crystal structure of arc4 from human tankyrase 2 in complex with peptide from human 3bp2 1.55Å AUTH S.GUETTLER,J.LAROSE,E.PETSALAKI,G.GISH,A.SCOTTER,T.PAWSON,AUTH 2 R.ROTTAPEL,F.SICHERITITL STRUCTURAL BASIS AND SEQUENCE RULES FOR SUBSTRATETITL 2 RECOGNITION BY TANKYRASE EXPLAIN THE BASIS FOR CHERUBISMTITL 3 DISEASE.REF CELL(CAMBRIDGE,MASS.) V. 147 1340 2011REFN ISSN 0092-8674PMID 22153077DOI 10.1016/J.CELL.2011.10.046 Variant Set Distributions […]
General Structure Information 2ilr FANCE crystal structure of human fanconi anemia protein e c- terminal domain 2.0Å AUTH R.K.NOOKALA,S.HUSSAIN,L.PELLEGRINITITL INSIGHTS INTO FANCONI ANAEMIA FROM THE STRUCTURETITL 2 OF HUMAN FANCEREF NUCLEIC ACIDS RES. V. 35 1638 2007REFN ISSN 0305-1048PMID 17308347DOI 10.1093/NAR/GKM033 Variant Set Distributions Mapped Variants
General Structure Information 2dba UNC45A the solution structure of the tetratrico peptide repeat of human smooth muscle cell associated protein-1, isoform 2 -1.0Å AUTH N.TOCHIO,A.SASAGAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE TETRATRICO PEPTIDETITL 2 REPEAT OF HUMAN SMOOTH MUSCLE CELL ASSOCIATEDTITL 3 PROTEIN-1, ISOFORM 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4h3k SSU72 crystal structure of a ternary complex of human symplekin ntd, human ssu72 and a rna polymerase ii ctd peptide phosphorylated at ser-2, ser-5 and ser-7 2.0Å AUTH K.XIANG,J.L.MANLEY,L.TONGTITL AN UNEXPECTED BINDING MODE FOR A POL II CTD PEPTIDETITL 2 PHOSPHORYLATED AT SER7 IN THE ACTIVE SITE OF THE CTDTITL 3 […]
General Structure Information 3hve GAN structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: gigaxoninbtb/3-box 2.8Å AUTH M.ZHUANG,M.F.CALABRESE,J.LIU,M.B.WADDELL,A.NOURSE,AUTH 2 M.HAMMEL,D.J.MILLER,H.WALDEN,D.M.DUDA,S.N.SEYEDIN,AUTH 3 T.HOGGARD,J.W.HARPER,K.P.WHITE,B.A.SCHULMANTITL STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTSTITL 2 INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITINTITL 3 LIGASES.REF MOL.CELL V. 36 39 2009REFN ISSN 1097-2765PMID 19818708DOI 10.1016/J.MOLCEL.2009.09.022 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3w3g TLR8 crystal structure of human tlr8 (unliganded form) 2.3Å AUTH H.TANJI,U.OHTO,T.SHIBATA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL REORGANIZATION OF THE TOLL-LIKE RECEPTOR 8 DIMERTITL 2 INDUCED BY AGONISTIC LIGANDSREF SCIENCE V. 339 1426 2013REFN ISSN 0036-8075PMID 23520111DOI 10.1126/SCIENCE.1229159 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dx1 TRPV4 crystal structure of the human trpv4 ankyrin repeat domain 2.85Å AUTH H.INADA,E.PROCKO,M.SOTOMAYOR,R.GAUDETTITL STRUCTURAL AND BIOCHEMICAL CONSEQUENCES OF DISEASE-CAUSINGTITL 2 MUTATIONS IN THE ANKYRIN REPEAT DOMAIN OF THE HUMAN TRPV4TITL 3 CHANNEL.REF BIOCHEMISTRY V. 51 6195 2012REFN ISSN 0006-2960PMID 22702953DOI 10.1021/BI300279B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2iqc FANCF crystal structure of human fancf protein that functions in the assembly of a dna damage signaling complex 2.4Å AUTH P.KOWAL,A.M.GURTAN,P.STUCKERT,A.D.DANDREA,AUTH 2 T.ELLENBERGERTITL STRUCTURAL DETERMINANTS OF HUMAN FANCF PROTEINTITL 2 THAT FUNCTION IN THE ASSEMBLY OF A DNA DAMAGETITL 3 SIGNALING COMPLEX.REF J.BIOL.CHEM. V. 282 2047 2007REFN ISSN 0021-9258PMID 17082180DOI 10.1074/JBC.M608356200 […]
General Structure Information 3b7b EHMT1 euhmt1 (glp) ankyrin repeat domain (structure 1) 2.99Å AUTH R.E.COLLINS,J.P.NORTHROP,J.R.HORTON,D.Y.LEE,AUTH 2 X.ZHANG,M.R.STALLCUP,X.CHENGTITL THE ANKYRIN REPEATS OF G9A AND GLP HISTONETITL 2 METHYLTRANSFERASES ARE MONO- AND DIMETHYLLYSINETITL 3 BINDING MODULESREF NAT.STRUCT.MOL.BIOL. V. 15 245 2008REFN ISSN 1545-9993PMID 18264113DOI 10.1038/NSMB.1384 Variant Set Distributions Mapped Variants