Assessment of Structural Intolerance and Durability
General Structure Information 1dc2 CDKN2A solution nmr structure of tumor suppressor p16ink4a, 20 structures -1.0Å AUTH C.YUAN,T.L.SELBY,J.LI,I.J.BYEON,M.D.TSAITITL TUMOR SUPPRESSOR INK4: REFINEMENT OF P16INK4ATITL 2 STRUCTURE AND DETERMINATION OF P15INK4B STRUCTURETITL 3 BY COMPARATIVE MODELING AND NMR DATA.REF PROTEIN SCI. V. 9 1120 2000REFN ISSN 0961-8368PMID 10892805 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1emo FBN1 nmr study of a pair of fibrillin ca2+ binding epidermal growth factor-like domains, 22 structures -1.0Å AUTH A.K.DOWNING,V.KNOTT,J.M.WERNER,C.M.CARDY,AUTH 2 I.D.CAMPBELL,P.A.HANDFORDTITL SOLUTION STRUCTURE OF A PAIR OF CALCIUM-BINDINGTITL 2 EPIDERMAL GROWTH FACTOR-LIKE DOMAINS: IMPLICATIONSTITL 3 FOR THE MARFAN SYNDROME AND OTHER GENETICTITL 4 DISORDERS.REF CELL(CAMBRIDGE,MASS.) V. 85 597 1996REFN ISSN 0092-8674PMID […]
General Structure Information 1elr STIP1 crystal structure of the tpr2a domain of hop in complex with the hsp90 peptide meevd 1.9Å AUTH C.SCHEUFLER,A.BRINKER,G.BOURENKOV,S.PEGORARO,AUTH 2 L.MORODER,H.BARTUNIK,F.U.HARTL,I.MOAREFITITL STRUCTURE OF TPR DOMAIN-PEPTIDE COMPLEXES:TITL 2 CRITICAL ELEMENTS IN THE ASSEMBLY OF THETITL 3 HSP70-HSP90 MULTICHAPERONE MACHINE.REF CELL(CAMBRIDGE,MASS.) V. 101 199 2000REFN ISSN 0092-8674PMID 10786835DOI 10.1016/S0092-8674(00)80830-2 Variant Set Distributions Mapped […]
General Structure Information 3bim BCL6 crystal structure of the bcl6 btb domain dimer in complex with the bcor bbd corepressor peptide 2.6Å AUTH A.F.GHETU,C.M.CORCORAN,L.CERCHIETTI,V.J.BARDWELL,AUTH 2 A.MELNICK,G.G.PRIVETITL STRUCTURE OF A BCOR COREPRESSOR PEPTIDE IN COMPLEXTITL 2 WITH THE BCL6 BTB DOMAIN DIMER.REF MOL.CELL V. 29 384 2008REFN ISSN 1097-2765PMID 18280243DOI 10.1016/J.MOLCEL.2007.12.026 Variant Set Distributions Mapped Variants
General Structure Information 2gl7 CTNNB1 crystal structure of a beta-catenin/bcl9/tcf4 complex 2.6Å AUTH J.SAMPIETRO,C.L.DAHLBERG,U.S.CHO,T.R.HINDS,D.KIMELMAN,W.XUTITL CRYSTAL STRUCTURE OF A BETA-CATENIN/BCL9/TCF4 COMPLEX.REF MOL.CELL V. 24 293 2006REFN ISSN 1097-2765PMID 17052462DOI 10.1016/J.MOLCEL.2006.09.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2he9 NKTR structure of the peptidylprolyl isomerase domain of the human nk-tumour recognition protein 2.0Å AUTH T.DAVIS,J.R.WALKER,E.M.NEWMAN,F.MACKENZIE,AUTH 2 C.BUTLER-COLE,P.J.FINERTY JR.,J.WEIGELT,AUTH 3 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 S.DHE-PAGANONTITL STRUCTURE OF THE PPIASE CYCLOPHILIN-TYPE DOMAIN OFTITL 2 THE HUMAN NK-TUMOR RECOGNITION PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c0l SCP2 tpr domain of human pex5p in complex with human mscp2 2.3Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants
General Structure Information 1svc NFKB1 nfkb p50 homodimer bound to dna 2.6Å AUTH C.W.MULLER,F.A.REY,M.SODEOKA,G.L.VERDINE,AUTH 2 S.C.HARRISONTITL STRUCTURE OF THE NF-KAPPA B P50 HOMODIMER BOUND TOTITL 2 DNA.REF NATURE V. 373 311 1995REFN ISSN 0028-0836PMID 7830764DOI 10.1038/373311A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b7x FKBP6 crystal structure of human fk506-binding protein 6 2.1Å AUTH J.R.WALKER,T.DAVIS,C.BUTLER-COLE,R.PARAMANATHAN,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL HUMAN FK506-BINDING PROTEIN 6.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants