Assessment of Structural Intolerance and Durability
General Structure Information 3ebb PLAA plap/p97 complex 1.9Å AUTH L.QIU,N.PASHKOVA,J.R.WALKER,S.WINISTORFER,A.ALLALI-HASSANI,AUTH 2 M.AKUTSU,R.PIPER,S.DHE-PAGANONTITL STRUCTURE AND FUNCTION OF THE PLAA/UFD3-P97/CDC48 COMPLEX.REF J.BIOL.CHEM. V. 285 365 2010REFN ISSN 0021-9258PMID 19887378DOI 10.1074/JBC.M109.044685 Variant Set Distributions Mapped Variants
General Structure Information 2ns2 SPIN1 crystal structure of spindlin1 2.2Å AUTH Q.ZHAO,L.QIN,F.JIANG,B.WU,W.YUE,F.XU,Z.RONG,H.YUAN,AUTH 2 X.XIE,Y.GAO,C.BAI,M.BARTLAM,X.PEI,Z.RAOTITL STRUCTURE OF HUMAN SPINDLIN1. TANDEM TUDOR-LIKETITL 2 DOMAINS FOR CELL CYCLE REGULATIONREF J.BIOL.CHEM. V. 282 647 2007REFN ISSN 0021-9258PMID 17082182DOI 10.1074/JBC.M604029200 Variant Set Distributions Mapped Variants
General Structure Information 4g8a LY96 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4c0p TNPO3 unliganded transportin 3 2.95Å AUTH G.N.MAERTENS,N.J.COOK,W.WANG,S.HARE,S.S.GUPTA,I.OZTOP,K.LEE,AUTH 2 V.E.PYE,O.COSNEFROY,A.P.SNIJDERS,V.N.KEWALRAMANI,A.FASSATI,AUTH 3 A.ENGELMAN,P.CHEREPANOVTITL STRUCTURAL BASIS FOR NUCLEAR IMPORT OF SPLICING FACTORS BYTITL 2 HUMAN TRANSPORTIN 3.REF PROC.NATL.ACAD.SCI.USA V. 111 2728 2014REFN ISSN 0027-8424PMID 24449914DOI 10.1073/PNAS.1320755111 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f37 TRPV2 crystal structure of the ankyrin repeat domain of human trpv2 1.7Å AUTH C.J.MCCLEVERTY,E.KOESEMA,A.PATAPOUTIAN,S.A.LESLEY,AUTH 2 A.KREUSCHTITL CRYSTAL STRUCTURE OF THE HUMAN TRPV2 CHANNELTITL 2 ANKYRIN REPEAT DOMAIN.REF PROTEIN SCI. V. 15 2201 2006REFN ISSN 0961-8368PMID 16882997DOI 10.1110/PS.062357206 Variant Set Distributions Mapped Variants
General Structure Information 4ch9 KLHL3 crystal structure of the human klhl3 kelch domain in complex with a wnk4 peptide 1.84Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Mapped Variants
General Structure Information 1xqr HSPBP1 crystal structure of the hspbp1 core domain 2.1Å AUTH Y.SHOMURA,Z.DRAGOVIC,H.C.CHANG,N.TZVETKOV,AUTH 2 J.C.YOUNG,J.L.BRODSKY,V.GUERRIERO,F.U.HARTL,AUTH 3 A.BRACHERTITL REGULATION OF HSP70 FUNCTION BY HSPBP1; STRUCTURALTITL 2 ANALYSIS REVEALS AN ALTERNATE MECHANISM FOR HSP70TITL 3 NUCLEOTIDE EXCHANGEREF MOL.CELL V. 17 367 2005REFN ISSN 1097-2765PMID 15694338DOI 10.1016/J.MOLCEL.2004.12.023 Variant Set Distributions Mapped Variants
General Structure Information 3ffl ANAPC7 crystal structure of the n-terminal domain of anaphase-promoting complex subunit 7 2.5Å AUTH D.HAN,K.KIM,Y.KIM,Y.KANG,Y.KIMTITL CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OFTITL 2 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4lg8 PRPF19 crystal structure of prpf19 wd40 repeats 1.89Å AUTH C.XU,W.TEMPEL,H.HE,E.DOBROVETSKY,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MIN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lg6 ANKRA2 crystal structure of ankra2-ccdc8 complex 1.8Å AUTH J.NIE,C.XU,J.JIN,J.A.AKA,W.TEMPEL,V.NGUYEN,L.YOU,R.WEIST,AUTH 2 J.MIN,T.PAWSON,X.J.YANGTITL ANKYRIN REPEATS OF ANKRA2 RECOGNIZE A PXLPXL MOTIF ON THE 3MTITL 2 SYNDROME PROTEIN CCDC8.REF STRUCTURE V. 23 700 2015REFN ISSN 0969-2126PMID 25752541DOI 10.1016/J.STR.2015.02.001 Variant Set Distributions Mapped Variants